After being diagnosed in her early forties with metastatic melanoma - a "rapidly fatal" form of cancer - journalist and mother of two Mary Elizabeth Williams finds herself in a race against the clock. She takes a once-in-a-lifetime chance and joins a clinical trial for immunotherapy, a revolutionary drug regimen that trains the body to vanquish malignant cells. Astonishingly, her cancer disappears entirely in just a few weeks. But at the same time, her best friend embarks on a cancer journey of her own - with very different results.

Audie Award, Humor, 2016. In Furiously Happy, number-one New York Times best-selling author Jenny Lawson explores her lifelong battle with mental illness. A hysterical, ridiculous book about crippling depression and anxiety? That sounds like a terrible idea. But terrible ideas are what Jenny does best.

A hilarious and emotional personal account of the life, times, mistakes, and crippling codependence of comedian, producer, director, actress, and writer Whitney Cummings. Full of intellect, pathos, and profundity, I'm Fine...and Other Lies is, in Whitney's words, her first book, which means her last date. With her signature incendiary edge and self-deprecation, Whitney comes clean about what has shaped her into the trailblazing comic that she is today.

By turns heartbreaking, hilarious, and utterly human, The House of God is a mesmerizing and provocative journey that takes us into the lives of Roy Basch and five of his fellow interns at the most renowned teaching hospital in the country.

In the span of four months in 2012, Tig Notaro was hospitalized for a debilitating intestinal disease called C. diff, her mother unexpectedly died, she went through a breakup, and then she was diagnosed with bilateral breast cancer. Hit with this devastating barrage, Tig took her grief onstage. Days after receiving her cancer diagnosis, she broke new comedic ground, opening an unvarnished set with the words, "Good evening. Hello. I have cancer. How are you? Hi, how are you? Is everybody having a good time? I have cancer."

Following up the phenomenal success of her headline-making New York Times bestseller I Hate Everyone...Starting With Me, the unstoppable Joan Rivers is at it again. When her daughter Melissa gives her a diary for Christmas, at first Joan is horrified—who the hell does Melissa think she is? That fat pig, Bridget Jones? But as Joan, being both beautiful and introspective, begins to record her day-to-day musings, she realizes she has a lot to say. About everything. And everyone, God help them..

People often say, "I feel like I've been run over by a truck." Katie actually was. On a sunny morning bike ride in Brooklyn, 24-year-old Katie McKenna was forever changed when she was run over by an 18-wheeler. Being crushed under a massive semi wasn't something Katie should have survived. After 10 hours of emergency surgery, she woke to find herself in a body and a life that would never be the same.

After watching too many family members die of cancer, at age 28, public speaker and comedian Caitlin Brodnick was tested for the BRCA1 gene mutation and tested positive, indicating an 87% chance she'd likely be diagnosed with breast cancer in her lifetime. She had a preventative double mastectomy, thereby becoming an everywoman's Angelina Jolie. Dangerous Boobies: Breaking Up with My Time-Bomb Breasts goes in depth into her experience from testing to surgery and on to recovery.

Part inspirational cancer-survival story, part memoir-as-laugh-riot, Fran Drescher's new book picks up where Enter Whining left off. After her marriage ended, her TV series was cancelled, and her beloved dog died, Fran started having symptoms no doctor could adequately explain. With her trademark humor, she tells of her tireless search for answers and the cancer diagnosis that she ultimately beat.

A month before her death on May 20, 1989, Gilda Radner entered a Los Angeles recording studio to deliver what would be her final performance - this remarkable audio autobiography, in which she reveals the inspirational story of her struggle with cancer...a private, personal battle in which the humor and humanity that has touched millions became her most powerful weapon.

Laurie Notaro has proved everyone wrong: she didn’t end up in rehab, prison, or cremated at a tender age. She just went gray. At past fifty, every hair’s root is a symbol of knowledge (she knows how to use a landline), experience (she rode in a car with no seat belts), and superpowers (a gray-haired lady can get away with anything). Though navigating midlife is initially upsetting—the cracking noises coming from her new old body, receiving regular junk mail from mortuaries—Laurie accepts it. And then some.

Julia Fox Garrison refused to listen to the professionals she called Dr. Jerk and Dr. Panic, who - after she suffered a massive, debilitating stroke at age thirty-seven - told her she’d probably die, or to Nurse Doom, who ignored her emergency call button. Instead she heeded the advice of kind, gifted Dr. Neuro, who promised her he would “treat your mind as well as your body.” Julia figured if she could somehow manage to get herself into a wheelchair, at least she’d always find parking. But after many, many months of hospitalization and rehab, Julia not only got into a wheelchair, but she got back out.

Wondering if science could explain how he survived his 40-year avalanche of drugs and alcohol, Ozzy Osbourne became one of a handful of people in the world to have his entire DNA mapped in 2010. It was a highly complex, $65,000 process, but the results were conclusive: Ozzy is a genetic anomaly. The "Full Ozzy Genome" contained variants that scientists had never before encountered and the findings were presented at the prestigious TEDMED Conference in San Diego - making headlines around the world.

At 30 years old Bryan Bishop’s life was right on track: as the sidekick on The Adam Carolla Show, his career was taking off and, newly engaged, his personal life was soaring to new heights. Then he was diagnosed with an inoperable brain tumor. Suddenly Bryan’s promising future was looking at a troubling schedule of radiation and chemotherapy. But having found refuge in comedy, "Bald Bryan" recounts his alternately heartbreaking and hysterical experience of cancer treatment and recovery.

Ally was at a breaking point when she woke up in a psych ward at the age of 18. She couldn't put a sentence together, let alone take a shower, eat a meal, or pick up a phone. What had gone wrong? In recent years, she had produced a feature film, a popular reality show for a major network, and had acted in an off-Broadway play. But now Ally was pushed to a psychotic break after struggling since she was seven years old with physical symptoms that no doctor could explain - everything from joint pain to night sweats, memory loss, nausea, and brain fog.

Julia Fox Garrison refused to listen to the professionals she called Dr. Jerk and Dr. Panic, who - after she suffered a massive, debilitating stroke at age thirty-seven - told her she’d probably die, or to Nurse Doom, who ignored her emergency call button. Instead she heeded the advice of kind, gifted Dr. Neuro, who promised her he would “treat your mind as well as your body.” Julia figured if she could somehow manage to get herself into a wheelchair, at least she’d always find parking. But after many, many months of hospitalization and rehab, Julia not only got into a wheelchair, but she got back out.

People often say, "I feel like I've been run over by a truck." Katie actually was. On a sunny morning bike ride in Brooklyn, 24-year-old Katie McKenna was forever changed when she was run over by an 18-wheeler. Being crushed under a massive semi wasn't something Katie should have survived. After 10 hours of emergency surgery, she woke to find herself in a body and a life that would never be the same.

When Amy B. Scher was struck with undiagnosed late-stage, chronic Lyme disease, the best physicians in America labeled her condition incurable and potentially terminal. Deteriorating rapidly, she went on a search to save her own life - from the top experts in Los Angeles and the world-renowned Mayo Clinic in Minneapolis to a state-of-the-art hospital in Chicago. After exhausting all of her options in the US, she discovered a possible cure - but it was highly experimental, available only in India, and had as much of a probability of killing her as it did of curing her.

The 1980s marked a revolution in the field of organ transplants, and Bud Shaw, MD, who studied under Tom Starzl in Pittsburgh, was on the front lines. Now retired from active practice, Dr. Shaw relays gripping moments of anguish and elation, frustration and reward, despair and hope in his struggle to save patients. He reveals harshly intimate moments of his medical career.

Dr. Kathy Magliato is one of fewer than a dozen female heart surgeons practicing in the world today. She is also a member of an even more exclusive group - those surgeons who perform heart transplants. Healing Hearts is the story of the making of a surgeon who also calls herself a wife and mother.

His name was Joshua Silver. He was 23 years old, educated, and had an impressive vocabulary. The NYPD had found Joshua Silver naked in Times Square, barking like a dog. It was just another night for Julie Holland, the attending doctor in the world famous Bellevue Hospital's psychiatric emergency room.

At age nine, Josh Sundquist was diagnosed with cancer, and by age 10, he'd lost his leg to the illness. But Sundquist never faltered in his dream to ski in the Paralympics, and in 2006 he achieved his goal in Turin, Italy.

Lauren Weedman is not okay. She's living what should be the good life in sunny Los Angeles. After a gig as a correspondent with The Daily Show with Jon Stewart, she scored parts in blockbuster movies, which led to memorable recurring roles on HBO's Hung and Looking. She had a loving husband and an adorable baby boy. In these comedic essays, she turns a piercingly observant, darkly funny lens on the ways her life is actually not okay.

When Edward M. Hallowell was 11, a voice out of nowhere told him he should become a psychiatrist. A mental health professional of the time would have called this psychosis. But young Edward (Ned) took it in stride, despite not quite knowing what "psychiatrist" meant. With a psychotic father, an alcoholic mother, an abusive stepfather, and two so-called learning disabilities of his own, Ned was accustomed to unpredictable behaviour from those around him and to a mind he felt he couldn't always control.

Oprah Winfrey has called him an inspiration, Maya Angelou saw him as a kindred spirit and fellow poet, and Jimmy Carter described Mattie Stepanek as the "most remarkable person I have ever known". When Jerry Lewis received his lifetime achievement award at the Oscars, footage of Mattie played behind him. Five years after his death from a rare neuromuscular disease, Mattie is still being celebrated for his indomitable spirit and message of hope.

In 2005, Dan Bucatinsky and his partner, Don Roos, found themselves in an L.A. delivery room, decked out in disposable scrubs from shower cap to booties, to welcome their adopted baby girl - launching their frantic yet memorable adventures into fatherhood. Two and a half years later, the same birth mother - a heroically generous, pack-a-day teen with a passion for Bridezilla marathons and Mountain Dew - delivered a son into the couple’s arms.

What do the lives of Lincoln, Helen Keller, Joan of Arc, and other historical figures have in common with Paula Poundstone? In the hands of this wryly observant and self-deprecating comedian, the answer is outrageously funny and unexpectedly touching. Poundstone compares her crazy life to theirs, as she holds forth on her children, her career, and the time in her life when it appeared she would lose them both.

Emma Forrest, a British journalist, was just 22 and living the fast life in New York City when she realized that her quirks had gone beyond eccentricity. In a cycle of loneliness, damaging relationships, and destructive behavior, she found herself in the chair of a slim, balding, and effortlessly optimistic psychiatrist--a man whose wisdom and humanity would wrench her from the dangerous tide after she tried to end her life.

When Joselin Linder was in her 20s, her legs started to swell. She thought little of it until her health problems started to compound in ways that baffled her doctors. Diagnosed with extreme liver blockage and dangerous levels of lymph fluid, Joselin turned to the most similar case she could think of - her father's.

In her former career as an English professor, Theresa Brown had been shielded from the harsh reality of death. That all changed the day she decided to become an oncology nurse. In Critical Care, Theresa writes powerfully and honestly about her first year on the hospital floor. With great compassion and a disarming sense of humor, she shares the trials and triumphs of her patients and comes to realize that caring for a patient means much more than simply treating a disease.