Born in the workhouse and adopted by a former suffragette, Frances Brakespeare was encouraged from an early age to be strong, independent and to pursue a career as a doctor. The tragic loss of the love of her life in the Great War propels Frances to commit to her one true vocation. Rebelling against the unfair treatment of female doctors Frances is dismissed from her London post and things continue to take a turn for the worse when Izzy, her benefactress dies and Frances finds herself homeless.

In the heart of Dressmakers' Alley, Madame Pauline’s sweatshop is rumoured to be a particularly unpleasant place to work. Filled with seamstresses paid a pittance who turn a blind eye to what darker activities are hidden behind locked doors. Young Winnie Brown is keen to prove her value to the Women Movement and secures a job as a seamstress to investigate the whispers of some unsavoury goings on. Her concerns are soon justified when she hears a desperate cry for help.

As war looms in Europe, 18-year-old Jane Shaw runs the household as an unpaid servant on a meagre budget. When tragedy strikes and she loses her beloved younger brother in suspicious circumstances, Jane takes a position in service looking after Ned, a troubled young boy. Here she meets dashing David Heron, Ned's Uncle and they form an immediate attachment until she is dismissed after being accused of stealing a piece of jewellery. Returning home, Jane and her sister, Melia, are soon orphaned and left at the mercy of their Aunt Alice.

1940, London. When Cordelia accepts the post of head librarian in Silver Town Library, her mother is more than a little disapproving. The East End has high levels of poverty and illiteracy, and her mother says it’s no place for a woman of her status. But Cordelia is determined to make a difference in these times of strife, and along with her colleagues, Jane and Mavis, she begins to help the local community, making sure everyone knows what the library can offer them. And maybe even a romance will blossom.

Cambridgeshire - March 1939. As the clouds of war begin to gather in Europe, the Talbot family of rural Blackberry Farm will be torn apart, just as so many families all over the world will be. Life will never be the same again. Whilst in London, the Salmons family will feel the pain of parting and loss. Brought together by war, the two families become intertwined and, as the outlook looks bleak, they must draw on each other’s strength to fight through the hard times.

Dublin, 1952. When Mary Kate Ryan receives a surprise inheritance from the woman who abandoned her as a tiny baby, she’s stunned. All her life, she has longed to know why her mother disappeared, and now she’s devastated to realize that every lonely night she spent without a home or family of her own, her mother knew exactly where she was.

Hampshire, 1913. Amidst the glitz and glamour of England’s High Society, Sarah Trenwith is more of a wallflower living in the shadow of her beautiful sister Marianne. But as the war approaches Sarah will have to step out of the place society and her family have assigned her if she’s to do her part and claim the love she always dreamed of from afar.

Bristol 1936. Jenny Crawford has resigned herself to a loveless marriage living hand to mouth with their two children. Like many others, husband Roy struggles to find work at the docks but a chance encounter turns the family's fortunes around. Not only does he get regular work but they are also allocated a council house on Coronation Close on the outskirts of the city. Jenny and the children are overjoyed, this is the fresh start she could only ever dream of. But trouble feels never too far away.

Maggie Bailey has not had an easy childhood. Her father, Michael, always too easy with his fists after spending the family’s rent money down the pub. Just sixteen, in love and blinded by promises, Maggie sees marriage to handsome Jack as her great escape. However, she soon finds herself abandoned with a beautiful baby when Jack disappears. Maggie is forced to seek a new life away from the East End of London and finds herself a job at a hotel in Yarmouth.

When Rachel qualifies as nurse, she does so because she wants to help others and make a difference. But she is also running from a past life that must stay hidden forever. Completing her training, Rachel moves to London but misses home desperately, so when she hears about an opportunity to train as a district nurse in a village near Rochdale, she seizes the opportunity, even though it will take her closer to the trouble she left behind. She knows nothing about Eastby End and she is shocked to find it a little more than a slum.

Maureen Jackson knew life as a trainee nurse wouldn't be easy, but she didn't expect her hospital to be badly bombed on her first shift. Plus Maureen still has her family and friends in Mulberry Lane to keep her busy - she's needed as much there as she is by her patients. Running the pub on the corner of Mulberry Lane, Peggy Ashley is used to taking in all sorts of waifs and strays. But the arrival of a dashing American captain has got tongues wagging about Mulberry Lane's favourite landlady....

Devon, 1918. When Jessie Hale loses her nursing job, she leaves London to become the nurse maid to the Kendle family. On arrival she finds the family in disarray. When their elderly Nanny suffers a bad fall, Jessie has to try to bring the household together. Gradually, Jessie finds her place in their lives. Jessie soon starts to love her life at Kendlebury Hall, but problems arise when her feelings for her employer start to change....

London 1940. As the war rages in Europe, Rose Brown steps on board a ship bound for America, hoping to escape the danger. She's frightened, but her widowed mammy and three sisters in Ireland need the money she earns as nanny to the rich Townsend family. But while Rose plays with baby Sarah in the salty spray on deck, disaster strikes, and the ocean liner begins to sink. In the chaos, Rose and the baby are separated from the family.

When Sally, Beth, Margaret and Rachel meet at a job interview for the wonderful new store in Oxford Street, they have no idea they will become lifelong friends. When all four girls are lucky enough to be selected as sales staff their exciting new adventure begins. Join them as they overcome heartbreak and grief, find love and happiness and remain united in their friendship, whatever life throws at them.

At the heart of Dover's Market Square lies the Castle's Café. A bustling, homely place run by the formidable Nellie Castle and her six children. Since the scandalous birth of her beloved son 10 years before, Marianne, Nellie's eldest daughter, has preferred to stay in the kitchen, hidden away from the town gossips. Overcome with shame, Marianne has never revealed the name of Donny's father - not even to her own mother. But with World War II just around the corner, Marianne's past catches up with her. And suddenly the lives of the Castle family become a lot more complicated.