Union laborer Rohr Furland begrudgingly takes a job on a space freighter piloted by Captain Future, an immature and slightly crazed captain with an obsession for early 20th-century science-fiction novels. When they receive a distress call from a nearby space station, Furland and the first officer blend the dangers of reality into the captain's fantasy world.

Friday, a secret courier, is thrown into an assignment under the command of her employer, a man she knows only as "Boss." She operates from and over a near-future Earth in North America, a vulgar and chaotic land comprised of dozens of independent states. In America's disunion, Friday keeps her balance nimbly with quick, expeditious solutions as she conquers one calamity and scrape after another.

Nancy Kranich (played by Emmy-nominated actress Natasha Lyonne of Russian Doll and Orange Is the New Black) is a night nurse on an orbiting space station. But Nancy hates her job, is sick of space, and longs to find adventure and a safe place to smoke cigarettes that won’t blow everyone up. But when Nancy gets caught up in an outer-space conspiracy involving President Kennedy, former vice-president Richard Nixon, and an intergalactic object that could change the course of history, she gets way more adventure than she bargained for.

June 1, 2288 - Europe's first starship, the EASS Galileo, launches on its maiden voyage to investigate an unidentified object, code-named Spindrift, which is traveling outside our solar system. An object that may be alien in origin. The Galileo disappears soon after...February 1, 2344 - The Galileo's shuttle returns to Earth carrying three surviving expedition members, who still appear to be the same age they were when they departed. They report that they have, indeed, made contact with an extraterrestrial race.

San Francisco, 1947. Bartender Sammy “Two Toes” Tiffin and the rest of the Cookie’s Coffee Irregulars—a ragtag bunch of working mugs last seen in Noir—are on the hustle: they’re trying to open a driving school; shanghai an abusive Swedish stevedore; get Mable, the local madam, and her girls to a Christmas party at the State Hospital without alerting the overzealous head of the S.F.P.D. vice squad.