Four young women have been found murdered—tortured and strangled in their own beds—all victims of the same brilliant monster. Using a skilled hand and the latest technology in forensic medicine, Kay Scarpetta begins the process of gathering the microscopic clues the latest battered body has to give.

An unidentified nude female sits propped against a fountain in Central Park. There are no signs of struggle. When Dr. Kay Scarpetta and her colleagues Benton Wesley and Pete Marino arrive on the scene, they instantly recognize the signature of serial killer Temple Brooks Gault. Scarpetta, on assignment with the FBI, visits the New York City morgue on Christmas morning, where she must use her forensic expertise to give a name to the nameless—a difficult task. But as she sorts through conflicting forensic clues, Gault claims his next victim.

On the eve of a top secret space mission, Captain Calli Chase detects a tripped alarm in the tunnels deep below a NASA research center. A NASA pilot, quantum physicist, and cybercrime investigator, Calli knows that a looming blizzard and government shutdown could provide the perfect cover for sabotage, with deadly consequences. As it turns out, the danger is worse than she thought. A spatter of dried blood, a missing security badge, a suspicious suicide—a series of disturbing clues point to Calli’s twin sister, Carme, who’s been MIA for days.

During the early hours of Christmas morning, chief medical examiner Dr. Kay Scarpetta receives a chilling call. The Phantom Slasher has struck again. The serial killer has terrorized Northern Virginia for months. His pattern is to stalk with a sophisticated technology that enables him to invade his victims' homes and watch their every move. They wake up to a ghost-like hologram before being murdered in their beds.

Vain and charismatic Walter Sickert made a name for himself as a painter in Victorian London. But the ghoulish nature of his art - as well as extensive evidence - points to another name, one that's left its bloody mark on the pages of history: Jack the Ripper. Cornwell has collected never-before-seen archival material - including a rare mortuary photo, personal correspondence and a will with a mysterious autopsy clause - and applied cutting-edge forensic science to open an old crime to new scrutiny.