Frances Oldham Kelsey, the FDA, and the Battle Against Thalidomide
Failed to add items
Add to Cart failed.
Add to Wish List failed.
Remove from wishlist failed.
Adding to library failed
Follow podcast failed
Unfollow podcast failed
Get 2 free audiobooks during trial.
Buy for $25.79
No default payment method selected.
We are sorry. We are not allowed to sell this product with the selected payment method
-
Narrated by:
-
Andrea Gallo
About this listen
In the early 1960s, Dr. Frances Oldham Kelsey of the U.S. Food and Drug Administration became one of the most celebrated women in America when she prevented a deadly sedative from entering the U.S. market. A Canadian-born pharmacologist and physician, Kelsey saved countless Americans from the devastating side effects of thalidomide, routinely given to pregnant women to prevent morning sickness.
As the FDA medical officer charged with reviewing Merrell Pharmaceutical’s application for approval in 1960–1961, Kelsey was unconvinced that there was sufficient evidence of the drug’s efficacy and safety. Despite substantial pressure, she held her ground for nineteen months while the extent of the drug’s worldwide damage became known—thousands of stillborn babies, as well as at least 10,000 children across forty-six countries born with severe deformities such as missing limbs, arms, and legs that resembled flippers, and improperly developed eyes, ears, and other organs.
As a result of Kelsey’s efforts, thalidomide was never sold in the United States.
The incident led Congress to pass the 1962 Drug Amendment, which fundamentally changed drug regulation in America. Those regulations, still in force today, required pharmaceutical companies to conduct phased clinical trials, obtain informed consent from participants in drug testing, and warn the FDA of adverse effects, and it granted the FDA important controls over prescription-drug advertising.
One of a small minority of women to earn an advanced degree in science in the 1930s, Kelsey faced challenges that resonate with women scientists to this day.
Revered by the public as a “good mother of science,” she went on to act as a formidable gatekeeper against other suspect drugs, such as diesthylstilbestrol (DES) and laetrile. As part of the team that tested anti-malarial drugs on prisoner volunteers during World War II, she later was instrumental in the formulation of ethical protocols for drug testing on prisoners and the vulnerable, including the elderly and children. Yet behind the public adulation, she faced professional jealousies and glass ceilings, political interference with FDA’s actions, and ongoing hostility from pharmaceutical industry officials. She was sustained and supported by family and friends, co-workers and mentors, and a lifetime commitment to good science.
Based upon FDA archival records, private family papers, and interviews with family and colleagues, this biography highlights the efforts and legacy of a pioneering woman of science whose contributions are still influential today.
Related to this topic
-
The Art of War
- By: Sun Tzu
- Narrated by: Aidan Gillen
- Length: 1 hr and 7 mins
- Unabridged
-
Overall
-
Performance
-
Story
The 13 chapters of The Art of War, each devoted to one aspect of warfare, were compiled by the high-ranking Chinese military general, strategist, and philosopher Sun-Tzu. In spite of its battlefield specificity, The Art of War has found new life in the modern age, with leaders in fields as wide and far-reaching as world politics, human psychology, and corporate strategy finding valuable insight in its timeworn words.
-
-
The actual book The Art of War, not a commentary
- By Fred271 on 12-31-19
By: Sun Tzu
-
Genghis Khan and the Making of the Modern World
- By: Jack Weatherford
- Narrated by: Jonathan Davis, Jack Weatherford
- Length: 14 hrs and 20 mins
- Unabridged
-
Overall
-
Performance
-
Story
The Mongol army led by Genghis Khan subjugated more lands and people in 25 years than the Romans did in 400. In nearly every country the Mongols conquered, they brought an unprecedented rise in cultural communication, expanded trade, and a blossoming of civilization.
-
-
Golden Horde/Platinum Listen
- By Cynthia on 12-11-13
By: Jack Weatherford
-
Flannery O'Connor and the Scandal of Faith
- By: Jessica Hooten Wilson, The Great Courses
- Narrated by: Jessica Hooten Wilson
- Length: 3 hrs and 5 mins
- Original Recording
-
Overall
-
Performance
-
Story
Across six revealing lectures, Professor Jessica Hooten Wilson will introduce you to one of the 20th century’s most fascinating and divisive writers in Flannery O’Connor and the Scandal of Faith. Beginning with an overview of her brief but remarkable life, Professor Wilson will then take you through an exploration of themes in O’Connor’s work and the hallmarks of her literary style. You’ll get a clearer picture of O’Connor’s historical and geographical context while digging into how her stories can transcend time and place.
-
-
Fascinating life cut short
- By KRoss on 11-21-24
By: Jessica Hooten Wilson, and others
-
The Last Days of Cabrini-Green
- By: Ben Austen, Harrison David Rivers
- Narrated by: Ben Austen, Patina Miller, Harry Lennix, and others
- Length: 3 hrs and 32 mins
- Original Recording
-
Overall
-
Performance
-
Story
In 1992, the deadliest year in Chicago’s history, seven-year-old Dantrell Davis was shot and killed in front of his elementary school inside the public housing complex Cabrini-Green. What happened to Dantrell led to a truce among Chicago’s gangs, but it also ignited a national panic about poverty and violence in America’s cities. Dantrell’s name would soon be used to demolish all of Chicago’s high-rise public housing, displacing tens of thousands of low-income families.
-
-
Chicago Housibg
- By Ruby on 11-21-24
By: Ben Austen, and others
-
MOVE: The Untold Story of an American Tragedy
- By: Curtis Bryant, Kevin Arbouet
- Narrated by: Tariq Trotter
- Length: 5 hrs and 19 mins
- Original Recording
-
Overall
-
Performance
-
Story
This searing audio documentary brings listeners deep inside the unforgettable story of MOVE, gaining unprecedented access to surviving MOVE members, elected officials from the era, eyewitnesses, and historians to create an indelible portrait of an American tragedy.
-
-
Balanced Examination of History
- By James Peacock on 08-14-24
By: Curtis Bryant, and others
-
The Autobiography of Malcolm X
- As Told to Alex Haley
- By: Malcolm X, Alex Haley
- Narrated by: Laurence Fishburne
- Length: 16 hrs and 52 mins
- Unabridged
-
Overall
-
Performance
-
Story
Experience a bold take on this classic autobiography as it’s performed by Oscar-nominated Laurence Fishburne. In this searing classic autobiography, originally published in 1965, Malcolm X, the Muslim leader, firebrand, and Black empowerment activist, tells the extraordinary story of his life and the growth of the Human Rights movement. His fascinating perspective on the lies and limitations of the American dream and the inherent racism in a society that denies its non-White citizens the opportunity to dream, gives extraordinary insight into the most urgent issues of our own time.
-
-
it's Nearly perfect
- By Kerry on 09-16-20
By: Malcolm X, and others
-
The Art of War
- By: Sun Tzu
- Narrated by: Aidan Gillen
- Length: 1 hr and 7 mins
- Unabridged
-
Overall
-
Performance
-
Story
The 13 chapters of The Art of War, each devoted to one aspect of warfare, were compiled by the high-ranking Chinese military general, strategist, and philosopher Sun-Tzu. In spite of its battlefield specificity, The Art of War has found new life in the modern age, with leaders in fields as wide and far-reaching as world politics, human psychology, and corporate strategy finding valuable insight in its timeworn words.
-
-
The actual book The Art of War, not a commentary
- By Fred271 on 12-31-19
By: Sun Tzu
-
Genghis Khan and the Making of the Modern World
- By: Jack Weatherford
- Narrated by: Jonathan Davis, Jack Weatherford
- Length: 14 hrs and 20 mins
- Unabridged
-
Overall
-
Performance
-
Story
The Mongol army led by Genghis Khan subjugated more lands and people in 25 years than the Romans did in 400. In nearly every country the Mongols conquered, they brought an unprecedented rise in cultural communication, expanded trade, and a blossoming of civilization.
-
-
Golden Horde/Platinum Listen
- By Cynthia on 12-11-13
By: Jack Weatherford
-
Flannery O'Connor and the Scandal of Faith
- By: Jessica Hooten Wilson, The Great Courses
- Narrated by: Jessica Hooten Wilson
- Length: 3 hrs and 5 mins
- Original Recording
-
Overall
-
Performance
-
Story
Across six revealing lectures, Professor Jessica Hooten Wilson will introduce you to one of the 20th century’s most fascinating and divisive writers in Flannery O’Connor and the Scandal of Faith. Beginning with an overview of her brief but remarkable life, Professor Wilson will then take you through an exploration of themes in O’Connor’s work and the hallmarks of her literary style. You’ll get a clearer picture of O’Connor’s historical and geographical context while digging into how her stories can transcend time and place.
-
-
Fascinating life cut short
- By KRoss on 11-21-24
By: Jessica Hooten Wilson, and others
-
The Last Days of Cabrini-Green
- By: Ben Austen, Harrison David Rivers
- Narrated by: Ben Austen, Patina Miller, Harry Lennix, and others
- Length: 3 hrs and 32 mins
- Original Recording
-
Overall
-
Performance
-
Story
In 1992, the deadliest year in Chicago’s history, seven-year-old Dantrell Davis was shot and killed in front of his elementary school inside the public housing complex Cabrini-Green. What happened to Dantrell led to a truce among Chicago’s gangs, but it also ignited a national panic about poverty and violence in America’s cities. Dantrell’s name would soon be used to demolish all of Chicago’s high-rise public housing, displacing tens of thousands of low-income families.
-
-
Chicago Housibg
- By Ruby on 11-21-24
By: Ben Austen, and others
-
MOVE: The Untold Story of an American Tragedy
- By: Curtis Bryant, Kevin Arbouet
- Narrated by: Tariq Trotter
- Length: 5 hrs and 19 mins
- Original Recording
-
Overall
-
Performance
-
Story
This searing audio documentary brings listeners deep inside the unforgettable story of MOVE, gaining unprecedented access to surviving MOVE members, elected officials from the era, eyewitnesses, and historians to create an indelible portrait of an American tragedy.
-
-
Balanced Examination of History
- By James Peacock on 08-14-24
By: Curtis Bryant, and others
-
The Autobiography of Malcolm X
- As Told to Alex Haley
- By: Malcolm X, Alex Haley
- Narrated by: Laurence Fishburne
- Length: 16 hrs and 52 mins
- Unabridged
-
Overall
-
Performance
-
Story
Experience a bold take on this classic autobiography as it’s performed by Oscar-nominated Laurence Fishburne. In this searing classic autobiography, originally published in 1965, Malcolm X, the Muslim leader, firebrand, and Black empowerment activist, tells the extraordinary story of his life and the growth of the Human Rights movement. His fascinating perspective on the lies and limitations of the American dream and the inherent racism in a society that denies its non-White citizens the opportunity to dream, gives extraordinary insight into the most urgent issues of our own time.
-
-
it's Nearly perfect
- By Kerry on 09-16-20
By: Malcolm X, and others
-
Mythology: Mega Collection
- Classic Stories from the Greek, Celtic, Norse, Japanese, Hindu, Chinese, Mesopotamian and Egyptian Mythology
- By: Scott Lewis
- Narrated by: Madison Niederhauser, Oliver Hunt
- Length: 31 hrs and 37 mins
- Unabridged
-
Overall
-
Performance
-
Story
Do you know how many wives Zeus had? Or how the famous Trojan War was caused by one beautiful lady? Or how Thor got his hammer? Give your imagination a real treat. This Mega Mythology Collection of eight audiobooks is for you....
-
-
An interesting set of introductions.
- By Kevin Potter on 05-30-19
By: Scott Lewis
-
Helter Skelter
- The True Story of the Manson Murders
- By: Vincent Bugliosi, Curt Gentry
- Narrated by: Scott Brick
- Length: 26 hrs and 29 mins
- Unabridged
-
Overall
-
Performance
-
Story
Prosecuting attorney in the Manson trial Vincent Bugliosi held a unique insider's position in one of the most baffling and horrifying cases of the 20th century: the cold-blooded Tate-LaBianca murders carried out by Charles Manson and four of his followers. What motivated Manson in his seemingly mindless selection of victims, and what was his hold over the young women who obeyed his orders? Now available for the first time in unabridged audio, the gripping story of this famous and haunting crime is brought to life by acclaimed narrator Scott Brick.
-
-
Everything I remembered about the case was wrong..
- By karen on 06-22-12
By: Vincent Bugliosi, and others
-
Fingerprints of the Gods
- The Quest Continues
- By: Graham Hancock
- Narrated by: Graham Hancock
- Length: 18 hrs and 31 mins
- Unabridged
-
Overall
-
Performance
-
Story
Fingerprints of the Gods is the revolutionary rewrite of history that has persuaded millions of listeners throughout the world to change their preconceptions about the history behind modern society. An intellectual detective story, this unique history audiobook directs probing questions at orthodox history, presenting disturbing new evidence that historians have tried - but failed - to explain.
-
-
Classic in Historical Mysteries
- By Kelly on 09-05-19
By: Graham Hancock
-
The Secret History of Christmas
- By: Bill Bryson
- Narrated by: Bill Bryson
- Length: 3 hrs and 3 mins
- Original Recording
-
Overall
-
Performance
-
Story
Christmas is the single biggest annual event on the planet, a time for merry-making, over-indulgence, peace, goodwill, and the occasional family row. It’s as comfortable and familiar as a pair of old shoes and yet still glittery and exciting. But what do you really know about it? It’s stuffed full of traditions and rituals that most of us have been observing all our lives without having the slightest idea of where they come from.
-
-
Fascinating and Entertaining
- By Laura Carrington on 11-23-22
By: Bill Bryson
-
World War 2 in the Pacific Collection: Across Wake Island, Bataan, Guadalcanal, Corregidor, and Iwo Jima
- Helmet for My Pillow: From Parris Island to the Pacific, The Saga of Pappy Gunn, On Valor's Side, The Coastwatchers, They Call it Pacific, Joe Foss Flying Marine, South from Corregidor, The Story of Wake Island, & Mission Beyond Darkness
- By: Robert Lackie, General George C. Kenney, T. Grady Gallant, and others
- Narrated by: Museum Audiobooks Cast
- Length: 66 hrs and 14 mins
- Unabridged
-
Overall
-
Performance
-
Story
This is a nine-book bundle on the Pacific War, the theatre of World War II that was fought in Asia, the Pacific Ocean, the Indian Ocean and Oceania. The Pacific War saw the Allies pitted against Japan, aided by Thailand and its Axis allies, Germany and Italy. Fighting included some of the largest naval battles in history, and the war culminated in the atomic bombings of Hiroshima and Nagasaki.
-
-
Good collection, great bargain well worth a credit
- By R. Denton on 08-13-21
By: Robert Lackie, and others
-
Black Elk Speaks
- Being the Life Story of a Holy Man of the Oglala Sioux, The Premier Edition
- By: John G. Neihardt
- Narrated by: Robin Neihardt
- Length: 6 hrs and 35 mins
- Unabridged
-
Overall
-
Performance
-
Story
Widely hailed as a spiritual classic, this inspirational and unfailingly powerful story reveals the life and visions of the Lakota healer Nicholas Black Elk (1863–1950) and the tragic history of his Sioux people during the epic closing decades of the Old West. In 1930, the aging Black Elk met a kindred spirit, the famed poet, writer, and critic John G. Neihardt (1881–1973) on the Pine Ridge Reservation in South Dakota.
-
-
Tale of tears
- By William Sanders on 01-25-15
By: John G. Neihardt