Stuart Ressler, an up-and-coming molecular biologist, finds his career sidetracked by the turmoil of the '60s, and a young couple of the 1980s tries to discover why the biologist abandoned his scientific pursuits.

Theo Byrne is a promising young astrobiologist who has found a way to search for life on other planets dozens of light years away. He is also the widowed father of a most unusual nine-year-old. His son, Robin, is funny, loving, and filled with plans. He thinks and feels deeply, adores animals, and can spend hours painting elaborate pictures. He is also on the verge of being expelled from third grade for smashing his friend's face with a metal thermos.

On Easter day, 1939, at Marian Anderson's epochal concert on the Washington Mall, David Strom, a German Jewish emigre scientist, meets Delia Daley, a young Philadelphia Negro studying to be a singer. Their mutual love of music draws them together, and - against all odds and better judgment - they marry. They vow to raise their children beyond time, beyond identity, steeped in song. But their three children must survive America's brutal here and now.

The Overstory unfolds in concentric rings of interlocking fable that range from antebellum New York to the late 20th-century Timber Wars of the Pacific Northwest and beyond. An air force loadmaster in the Vietnam War is shot out of the sky, then saved by falling into a banyan. An artist inherits 100 years of photographic portraits, all of the same doomed American chestnut. A hard-partying undergraduate in the late 1980s electrocutes herself, dies, and is sent back into life by creatures of air and light.

Something is wrong with Eddie Hobson Sr., father of four, sometime history teacher, quiz master, black humorist, and virtuoso invalid. His recurring fainting spells have worsened, and with his ingrained aversion to doctors, his worried family tries to discover the nature of his sickness. Meanwhile, in private, Eddie puts the finishing touches on a secret project he calls Hobbstown, a place that he promises will save him, the world, and everything that's in it. A dazzling novel of compassion and imagination, Prisoner's Dilemma is a story of the power of invalid experience.

In a digital laboratory on the shores of Puget Sound, a band of virtual reality researchers race to complete the Cavern, an empty white room that can become a jungle, a painting, or a vast Byzantine cathedral. In a war-torn Mediterranean city, an American is held hostage, chained to a radiator in another empty white room. What can possibly join two such remote places? Only the shared imagination, a room that these people unwittingly build in common, where they are all about to meet, where the dual frames of this inventive novel to coalesce.

In Orfeo, Powers tells the story of a man journeying into his past as he desperately flees the present. Composer Peter Els opens the door one evening to find the police on his doorstep. His home microbiology lab - the latest experiment in his lifelong attempt to find music in surprising patterns - has aroused the suspicions of Homeland Security. Panicked by the raid, Els turns fugitive. As an Internet-fueled hysteria erupts, Els - the "Bioterrorist Bach" - pays a final visit to the people he loves, those who shaped his musical journey.

After several years living abroad, the fictional protagonist of Galatea 2.2 - Richard Powers - returns to the US as Humanist-in-Residence at the enormous Center for the Study of Advanced Sciences. There he runs afoul of Philip Lentz, a cognitive neurologist intent upon modeling the human brain. Lentz involves Powers in an outlandish and irresistible project: to train a neural net on a canonical list of Great Books. Through repeated tutorials, the device grows gradually more worldly, until it demands to know its own name, sex, race, and reason for existing.

Gain braids together two stories on very different scales. In one, Laura Body, divorced mother of two and a real estate agent in the small town of Lacewood, Illinois, plunges into a new existence when she learns she has ovarian cancer. In the other, Clare & Company, a soap manufacturer begun by three brothers in 19th-century Boston, grows over the course of a century and a half into an international consumer products conglomerate based in Laura's hometown.

Spanning the years 1900 to 1977, The Covenant of Water is set in Kerala, on South India’s Malabar Coast, and follows three generations of a family that suffers a peculiar affliction: in every generation, at least one person dies by drowning—and in Kerala, water is everywhere. At the turn of the century, a twelve-year-old girl from Kerala’s long-existing Christian community, grieving the death of her father, is sent by boat to her wedding, where she will meet her forty-year-old husband for the first time.

Agnes is a wild creature who walks her family’s land with a falcon on her glove and is known throughout the countryside for her unusual gifts as a healer, understanding plants and potions better than she does people. Once she settles with her husband on Henley Street in Stratford-upon-Avon, she becomes a fiercely protective mother and a steadfast, centrifugal force in the life of her young husband, whose career on the London stage is taking off when his beloved young son succumbs to sudden fever.

When the world is still counting the cost of the Second World War and the Iron Curtain has closed, eleven-year-old Roland Baines's life is turned upside down. 2,000 miles from his mother's protective love, stranded at an unusual boarding school, his vulnerability attracts piano teacher Miss Miriam Cornell, leaving scars as well as a memory of love that will never fade.

You are a failed novelist about to turn 50. A wedding invitation arrives in the mail: Your boyfriend of the past nine years is engaged to someone else. You can't say yes - it would be too awkward - and you can't say no - it would look like defeat. On your desk are a series of invitations to half-baked literary events around the world. Question: How do you arrange to skip town? Answer: You accept them all.

Esme is born into a world of words. Motherless and irrepressibly curious, she spends her childhood in the Scriptorium, an Oxford garden shed in which her father and a team of dedicated lexicographers are collecting words for the very first Oxford English Dictionary. Young Esme’s place is beneath the sorting table, unseen and unheard. One day a slip of paper containing the word bondmaid flutters beneath the table. She rescues the slip and, learning that the word means “slave girl,” begins to collect other words discarded or neglected by the dictionary men.

It is three in the morning when Bobby Western plunges from the Coast Guard tender into darkness. His dive light illuminates the sunken jet, nine bodies still buckled in their seats, hair floating, eyes devoid of speculation. Missing from the site are the pilot’s bag, the plane’s black box, and the tenth passenger. A collateral witness to machinations that can only bring him harm, Western is shadowed in body and spirit—by men with badges; by the ghost of his father, inventor of the bomb that melted glass and flesh in Hiroshima; and by his sister, the love and ruin of his soul.

Stuart Ressler, an up-and-coming molecular biologist, finds his career sidetracked by the turmoil of the '60s, and a young couple of the 1980s tries to discover why the biologist abandoned his scientific pursuits.

After several years living abroad, the fictional protagonist of Galatea 2.2 - Richard Powers - returns to the US as Humanist-in-Residence at the enormous Center for the Study of Advanced Sciences. There he runs afoul of Philip Lentz, a cognitive neurologist intent upon modeling the human brain. Lentz involves Powers in an outlandish and irresistible project: to train a neural net on a canonical list of Great Books. Through repeated tutorials, the device grows gradually more worldly, until it demands to know its own name, sex, race, and reason for existing.

On a winter night on a remote Nebraska road, 27-year-old Mark Schluter flips his truck in a near fatal accident. His older sister, Karin, returns to nurse Mark back from a traumatic head injury. But when he emerges from a coma, Mark believes that this woman is really an impostor who looks just like his sister. Shattered, Karin contacts the cognitive neurologist Gerald Weber, who eagerly investigates. What he discovers in Mark slowly undermines even his own sense of being.

In a digital laboratory on the shores of Puget Sound, a band of virtual reality researchers race to complete the Cavern, an empty white room that can become a jungle, a painting, or a vast Byzantine cathedral. In a war-torn Mediterranean city, an American is held hostage, chained to a radiator in another empty white room. What can possibly join two such remote places? Only the shared imagination, a room that these people unwittingly build in common, where they are all about to meet, where the dual frames of this inventive novel to coalesce.

Something is wrong with Eddie Hobson Sr., father of four, sometime history teacher, quiz master, black humorist, and virtuoso invalid. His recurring fainting spells have worsened, and with his ingrained aversion to doctors, his worried family tries to discover the nature of his sickness. Meanwhile, in private, Eddie puts the finishing touches on a secret project he calls Hobbstown, a place that he promises will save him, the world, and everything that's in it. A dazzling novel of compassion and imagination, Prisoner's Dilemma is a story of the power of invalid experience.

On Easter day, 1939, at Marian Anderson's epochal concert on the Washington Mall, David Strom, a German Jewish emigre scientist, meets Delia Daley, a young Philadelphia Negro studying to be a singer. Their mutual love of music draws them together, and - against all odds and better judgment - they marry. They vow to raise their children beyond time, beyond identity, steeped in song. But their three children must survive America's brutal here and now.

In Orfeo, Powers tells the story of a man journeying into his past as he desperately flees the present. Composer Peter Els opens the door one evening to find the police on his doorstep. His home microbiology lab - the latest experiment in his lifelong attempt to find music in surprising patterns - has aroused the suspicions of Homeland Security. Panicked by the raid, Els turns fugitive. As an Internet-fueled hysteria erupts, Els - the "Bioterrorist Bach" - pays a final visit to the people he loves, those who shaped his musical journey.

Gain braids together two stories on very different scales. In one, Laura Body, divorced mother of two and a real estate agent in the small town of Lacewood, Illinois, plunges into a new existence when she learns she has ovarian cancer. In the other, Clare & Company, a soap manufacturer begun by three brothers in 19th-century Boston, grows over the course of a century and a half into an international consumer products conglomerate based in Laura's hometown.

Theo Byrne is a promising young astrobiologist who has found a way to search for life on other planets dozens of light years away. He is also the widowed father of a most unusual nine-year-old. His son, Robin, is funny, loving, and filled with plans. He thinks and feels deeply, adores animals, and can spend hours painting elaborate pictures. He is also on the verge of being expelled from third grade for smashing his friend's face with a metal thermos.

In the spring of 1914, renowned photographer August Sander took a photograph of three young men on their way to a country dance. This haunting image, capturing the last moments of innocence on the brink of World War I, provides the central focus of Powers' brilliant and compelling novel. As the fate of the three farmers is chronicled, two contemporary stories unfold.