Greg Benedict watches in horror as his wife and baby stand by the window inside of a burning building. Then, before the flames reach them, they vanish. It was just the beginning. Sporadic vanishings occur over the next several months, all leading to the day when half the population disappears. Gone. Chaos ensues as humanity struggles to come to grips with the sudden vanishing of half the life on Earth.

Since childhood Nila Carter has been made to spend every weekend at the family cabin. In her teenage years she believes it to be a prison; as an adult it becomes her sanctuary and means to survive. When a mysterious outbreak occurs in India, Nila's brother, Bobby, a virologist with the CDC, places the family on a precautionary alert to be ready to bug out. Unlike anything he's ever seen, the rabies-like virus is not just deadly; it causes extreme violent behavior in those infected.

For the first time since his divorce, CJ will be able to take his son on a vacation. Along with his father, they make it a guys’ trip to the west coast. Little do they know their trip that is intended to be a lifetime of memories would include facing insurmountable odds. The lack of warning leaves everyone in the dark about what has occurred and vulnerable to all that unfolds. It doesn’t stop with the meteors. The disastrous events come one after another, a domino effect of annihilation.

On Memorial Day afternoon, the skies above Carthage, Missouri, brighten suddenly as if the sun explodes. Seconds later it's gone, and no one knows what happened. Normal life resumes. BBQs continue, and kids play in backyards. No one notices the screams coming from one backyard. It doesn't just happen in Carthage; it happens all over. While delayed, the aftereffects of the event are brutal to all those who were exposed to the flash, and horrifying to behold. Those not exposed, like Alana Cross, are helpless to do anything. All they can do is witness humanity self-destructing.

Following a control breach at a top-secret facility, a weapons grade biological pathogen, YPP-234, escapes and quickly spirals out of control. It is deadly, it is fast, and it goes unnoticed until it is too late. YPP-234 isn’t just a manmade biological weapon, it is a manmade extinction level event. Now it is out.