Ellen O'Casey, an Irish Catholic immigrant, is struggling to support her ailing mother, her teenage daughter and herself. Washing other people's laundry in the day, and singing in bawdy pubs at night, Ellen is determined to make a better life for her family by saving enough for the passage to New York where the rest of her extended family have already emigrated. But Danny Donovan, a local gangster and the landlord of the pubs where Ellen sings, intends to make her his mistress.

Hamburg, 1942. Seventeen-year-old Anna knows she can never tell her proud parents the truth about where she is going. She must hide the fact that she is pregnant, that the father of her unborn child is dead, and that she is on her way to a special maternity home, where her baby will be given to a perfect family. She tells herself that this is the best solution. She doesn’t expect to feel the rush of love for her beautiful baby boy in the white blanket or the devastation when he is snatched from her, never to be seen again.

1940, Liverpool: Alice Turner and her best friend, Millie Markham, work for the war effort at Rootes munitions factory, making shell caps and Halifax bombers. Alice’s sweetheart, Terry, is home from the front for a brief period of leave. But the honeymoon is soon over. Terry must go back to the dangers of Nazi-occupied France, and the ever-present air raid sirens quickly bring Alice back down to earth.

Sophie Whalen is a young Irish immigrant so desperate to get out of a New York tenement that she answers a mail-order bride ad and agrees to marry a man she knows nothing about. San Francisco widower Martin Hocking proves to be as aloof as he is mesmerizingly handsome. Sophie quickly develops deep affection for Kat, Martin's silent five-year-old daughter, but Martin's odd behavior leaves her with the uneasy feeling that something about her newfound situation isn't right.

Clara Newton is the new Housemother of Shilling Grange Orphanage. Many of the children have been bombed out of their homes and left without families, their lives torn apart by the war, just like Clara’s. Devastated by the loss of her fiancé, a brave American pilot, she is just looking for a place to start again. But the orphans are in desperate need of her help.