We are 40 years into the future, and London is a city in decay. John Watson has returned from medical service in the war in Afghanistan and lives by himself in a run-down part of ​town. On his way home from work, he stumbles upon a beaten man in the street – unconscious and completely naked. His chances of survival are minimal. The same evening, a passenger plane crashes in Richmond Park. There are several hundred victims, and Watson and the mysterious man are left to their own devices.

From the Supernatural Case Files of Sherlock Holmes London's most beloved detective encounters his most deadly foe, and the results will be unlike any Sherlock Holmes adventure before it!

In the summer of 1994, a workman at the historic mansion of railroad baron James J. Hill in St. Paul, Minnesota, stumbles on a long-hidden wall safe. When experts arrive to open the safe and examine its contents, they make an astonishing discovery. There, inside, is a handwritten manuscript bearing the signature of John H. Watson, MD. The manuscript contains the story of how Sherlock Holmes and Watson traveled to Minnesota to track a murderous arsonist - known only as the Red Demon - who is threatening both Hill and his Great Northern Railway.

London. A snowy December, 1888. Sherlock Holmes, 34, is languishing and back on cocaine after a disastrous Ripper investigation. Watson can neither comfort nor rouse his friend - until a strangely encoded letter arrives from Paris. Mlle La Victoire, a beautiful French cabaret star, writes that her illegitimate son by an English lord has disappeared, and she has been attacked in the streets of Montmartre.

Spring, 1918. The Great War is at a crucial stage, the Germans are making one last push into France, and the Allies are struggling to hold them back. Battle lines are shifting, and men, and their machines, are being sent up and down the front to shore up defenses. Major Heathcliff Lennox, and his batman Greggs, are told to report to their new HQ. They set off on a sunlit day to fly the distance, but the enemy is never far away, and disaster strikes. They're sent crashing to the ground behind enemy lines, where life, death, and love await.