Monica Tsai spends most days on her computer, journaling the details of her ordinary life and coding for a program that seeks to connect strangers online. A self-proclaimed recluse, she's always struggled to make friends and, as a college freshman, finds herself escaping into a digital world, counting the days until she can return home to her beloved grandparents. They are now in their nineties, and Monica worries about them constantly—especially her grandmother, Yun, who survived two wars in China before coming to the States, and whose memory has begun to fade.

New York City is filled with opportunities for single girls like Alice Weiss, who leaves her small Midwestern town to chase her big-city dreams and unexpectedly lands a job working for the first female editor in chief of Cosmopolitan magazine, Helen Gurley Brown. For Alice, who wants to be a photographer, it seems like the perfect foot in the door, but nothing could have prepared her for the world she enters.

For twenty-four-year-old Jane, finding love in New York City is even harder than making it as a playwright. So when Jane meets Colin, she can’t believe her luck: they’re perfect for each other. Even when Colin breaks off their relationship after six dates, Jane knows this is just a stumbling block. She’ll get him back. She knows she will. That is, until Colin starts dating Zoe—perfect, luminous Zoe. Even worse, she’s actually kind of nice. But Zoe doesn’t have what it takes to love Colin. All Jane has to do is prove it, and they’ll be so happy together.

Ever since her dad left them twenty years ago, it’s just been Madeline Hill and her mom on their farm in Coalfield, Tennessee. While she sometimes admits it’s a bit lonely and a less exciting life than she imagined for herself, it’s mostly OK. Mostly. Then one day Reuben Hill pulls up in a PT Cruiser and informs Madeline that he believes she’s his half sister.

Joan Goodwin has been obsessed with the stars for as long as she can remember. Thoughtful and reserved, Joan is content with her life as a professor of physics and astronomy at Rice University and as aunt to her precocious niece, Frances. That is, until she comes across an advertisement seeking the first women scientists to join NASA’s space shuttle program. Suddenly, Joan burns to be one of the few people to go to space.