Denied a dog, a baby, and even a faithful boyfriend, Cat decides that she needs a snake: a glistening, writhing creature that can be worn like “jewelry, living jewelry.” But when the budding social influencer finally gives in to impulse, buying a Burmese python from a local pet shop, she sets in motion a chain of increasingly dire events that culminates in one of the most memorable denouements in recent fiction, one that ensnares her entire family, from her eco-obsessed parents, Ottilie and Frank, to her frat-boy-turned-husband, Todd.

In 1943, LSD is synthesized in Basel. Two decades later, a coterie of grad students at Harvard are gradually drawn into the inner circle of renowned psychologist and psychedelic drug enthusiast Timothy Leary. Fitzhugh Loney, a psychology PhD student, and his wife, Joanie, become entranced by the drug’s possibilities such that their “research” becomes less a matter of clinical trials and academic papers and instead turns into a freewheeling exploration of mind expansion, group dynamics, and communal living.

Topanga Canyon is home to two couples on a collision course. Los Angeles liberals Delaney and Kyra Mossbacker lead an ordered, sushi-and-recycling existence in a newly gated hilltop community: He is a sensitive nature writer, she an obsessive realtor. Mexican illegals Candido and America Rincon desperately cling to their vision of the American Dream as they fight off starvation in a makeshift camp deep in the ravine.

In the title story of Walk Between the Raindrops, a woman sits down next to a man at a bar and claims she has ESP. In “Thirteen Days,” passengers on a cruise line are quarantined, to horrifying and hilarious effect. And “Hyena” begins simply: “That was the day the hyena came for him, and never mind that there were no hyenas in the South of France, and especially not in Pont-Saint-Esprit—it was there and it came for him.”

Told through the experiences of the four women who loved him, this imaginative account of Frank Lloyd Wright's raucous life blazes with Boyle's trademark wit and invention. Boyle's protean voice captures these very different women and, in doing so, creates a masterful ode to the creative life in all its complexity and grandeur.