Sam Hill always saw the world through different eyes. Born with red pupils, he was called “Devil Boy” or Sam “Hell” by his classmates; “God’s will” is what his mother called his ocular albinism. Her words were of little comfort, but Sam persevered. Sam believed it was God who sent Ernie Cantwell, the only African American kid in his class, to be the friend he so desperately needed. And that it was God’s idea for Mickie Kennedy to storm into Our Lady of Mercy like a tornado, uprooting every rule Sam had been taught about boys and girls. Forty years later, Sam, a small-town eye doctor, is no longer certain anything was by design.

Beautiful and courageous, Samantha Hargrave dares to dream that she will become one of the first female doctors - and surgeons - in America. Born in the slums of London and possessing a special gift for healing, Samantha struggles to enter the all-male medical profession. When her ambition encounters hostile rejection in England, she sails to America, where she meets an eccentric doctor who takes her on as an apprentice.

Two women develop a groundbreaking surgery: the Cesarean section. It's a highly dangerous procedure and the research is grueling, but even worse is the vitriolic response from men. Most don't trust the findings of women, and many can choose to deny their wives medical care. Already facing resistance on all sides, Nora is shaken when she meets a patient who will die without the surgery. If the procedure is successful, her work could change the world. But a failure could cost everything: precious lives, Nora's career, and the role women will be allowed to play in medicine.

In 1917 Dr. Grace Treverton arrives in Kenya determined to bring modern medicine to the African natives. Her brother, Sir Valentine Treverton, has his own dream for the British protectorate: to establish an agricultural empire to rival any in England. The aspirations of the wealthy Trevertons collide with those of the Mathenge tribe, an African family that has lived on the land for years. Grace soon finds a deadly rival in Mama Wachera, an African medicine woman who fights to maintain native traditions against the encroaching whites.

Australia, 1871. Following her mother's sudden death, Joanna Drury sets sail from India and arrives in Melbourne to claim the property left to her by her mother - and to trace the mysteries of her family's past. From her first steps on shore, Joanna becomes entangled with a lost boy who leads her to the fascinating Hugh Westbrook. She agrees to look after the child in exchange for Hugh's help in finding her inheritance. But she falls deeply in love with Hugh and with life at his sheep station, Merinda.