Dr. Jamison is one of the foremost authorities on manic-depressive (bipolar) illness; she has also experienced it firsthand. For even while she was pursuing her career in academic medicine, Jamison found herself succumbing to the same exhilarating highs and catastrophic depressions that afflicted many of her patients, as her disorder launched her into ruinous spending sprees, episodes of violence, and an attempted suicide.

In The Butchering Art, the historian Lindsey Fitzharris reveals the shocking world of 19th-century surgery on the eve of profound transformation. She conjures up early operating theaters - no place for the squeamish - and surgeons, working before anesthesia, who were lauded for their speed and brute strength. They were baffled by the persistent infections that kept mortality rates stubbornly high. A young, melancholy Quaker surgeon named Joseph Lister would solve the deadly riddle and change the course of history.

At the age of 27, married, living in New York, and working in book design, Mary Cregan gives birth to her first child, a daughter she names Anna. But it’s apparent that something is terribly wrong, and two days later, Anna dies - plunging Cregan into suicidal despair. Decades later, sustained by her work, a second marriage, and a son, Cregan reflects on this pivotal experience and attempts to make sense of it. She weaves together literature and research with details from her own ordeal - and the still visible scar of her suicide attempt....

An intimate, moving book written with the immediacy and directness of one who still struggles with the effects of mental and chronic illness, The Collected Schizophrenias cuts right to the core. Schizophrenia is not a single unifying diagnosis, and Esmé Weijun Wang writes not just to her fellow members of the “collected schizophrenias” but to those who wish to understand it as well.

Hallucinations don’t belong wholly to the insane. Much more commonly, they are linked to sensory deprivation, intoxication, illness, or injury. Here Dr. Sacks weaves together stories of his patients and of his own mind-altering experiences to illuminate what hallucinations tell us about the organization and structure of our brains, how they have influenced every culture’s folklore and art, and why the potential for hallucination is present in us all.

From the best-selling author of Gratitude and On the Move, a final volume of essays that showcase Sacks's broad range of interests - from his passion for ferns, swimming, and horsetails, to his final case histories exploring schizophrenia, dementia, and Alzheimer's.

A work of great personal courage and a literary tour de force, this bestseller is Styron's true account of his experience of crippling depression. Styron is perhaps the first writer to convey the full terror of depression's psychic landscape, as well as the illuminating path to recovery.

Due to horrible physical deformities, he spent much of his life as a fairground freak. He was hounded, persecuted, and starving, until his fortune changed and he was rescued, housed, and fed by the distinguished surgeon, Frederick Treves. The subject of several books, a Broadway hit, and a film, Joseph Merrick has become part of popular mythology. Here, in this fully revised edition containing much fresh information, are the true and un-romanticized facts of his life.

In his Pulitzer Prize-winning poetry, Robert Lowell put his manic-depressive illness (now known as bipolar disorder) into the public domain, creating a language for madness that was new and arresting. As Dr. Jamison brings her expertise in mood disorders to bear on Lowell’s story, she illuminates not only the relationships among mania, depression, and creativity but also the details of Lowell’s treatment and how illness and treatment influenced the great work that he produced (and often became its subject).

Awakenings - which inspired the major motion picture - is the remarkable story of a group of patients who contracted sleeping sickness during the great epidemic just after World War I. Frozen for decades in a trance-like state, these men and women were given up as hopeless until 1969, when Dr. Oliver Sacks gave them the then-new drug L-DOPA, which had an astonishing, explosive, "awakening" effect. Dr. Sacks recounts the moving case histories of his patients, their lives, and their extraordinary transformations.

Charlotte Brontë's life contained all the drama and tragedy of the great Gothic novels it inspired. Like Jane Eyre, she was raised motherless on remote Yorkshire moors and sent away to a brutally strict boarding school at a young age. Charlotte grew up and watched helplessly as, one by one, her five beloved siblings sickened and died; by the end of her short life, she was the only child of the Brontë clan remaining.

Nietzsche wrote that all philosophy is autobiographical, and in this vividly compelling, myth-shattering biography, Sue Prideaux brings listeners into the world of this brilliant, eccentric, and deeply troubled man, illuminating the events and people that shaped his life and work. I Am Dynamite! is the essential biography for anyone seeking to understand history's most misunderstood philosopher.

Drawing on rarely consulted archives, Crews shows us a man who blundered tragicomically in his dealings with patients, who never produced a corroborated cure, who promoted cocaine in one decade and was deluded by it in the next, who misunderstood the psychological controversies of the era, and who advanced his career through falsifying case histories and betraying the mentors who had helped him to rise.

In his perceptive and moving depiction of Ivan Ilych, a worldly careerist facing his own mortality in the midst of a self-absorbed family and indifferent colleagues, Tolstoy provides one of literature's greatest and most memorable reflections on the meaning of the good life and on life as preparation for death.

For anyone who ever wondered what Marcel Proust had in mind when he wrote the one-and-a-quarter-million words of In Search of Lost Time (while bedridden no less), Alain de Botton has the answer. For, in this stylish, erudite and frequently hilarious book, de Botton dips deeply into Proust’s life and work - his fiction, letter, and conversations – and distils from them that rare self-help manual: one that is actually helpful.

From the best-selling author of Gratitude and On the Move, a final volume of essays that showcase Sacks's broad range of interests - from his passion for ferns, swimming, and horsetails, to his final case histories exploring schizophrenia, dementia, and Alzheimer's.

Due to horrible physical deformities, he spent much of his life as a fairground freak. He was hounded, persecuted, and starving, until his fortune changed and he was rescued, housed, and fed by the distinguished surgeon, Frederick Treves. The subject of several books, a Broadway hit, and a film, Joseph Merrick has become part of popular mythology. Here, in this fully revised edition containing much fresh information, are the true and un-romanticized facts of his life.

This Close to Happy is the rare, vividly personal account of what it feels like to suffer from clinical depression, written from a woman's perspective and informed by an acute understanding of the implications of this disease over a lifetime. Taking off from essays on depression she has written for The New Yorker and The New York Times Magazine, Daphne Merkin casts her eye back to her beginnings to try to sort out the root causes of her affliction.

Charlotte Brontë's life contained all the drama and tragedy of the great Gothic novels it inspired. Like Jane Eyre, she was raised motherless on remote Yorkshire moors and sent away to a brutally strict boarding school at a young age. Charlotte grew up and watched helplessly as, one by one, her five beloved siblings sickened and died; by the end of her short life, she was the only child of the Brontë clan remaining.

Nietzsche wrote that all philosophy is autobiographical, and in this vividly compelling, myth-shattering biography, Sue Prideaux brings listeners into the world of this brilliant, eccentric, and deeply troubled man, illuminating the events and people that shaped his life and work. I Am Dynamite! is the essential biography for anyone seeking to understand history's most misunderstood philosopher.

For anyone who ever wondered what Marcel Proust had in mind when he wrote the one-and-a-quarter-million words of In Search of Lost Time (while bedridden no less), Alain de Botton has the answer. For, in this stylish, erudite and frequently hilarious book, de Botton dips deeply into Proust’s life and work - his fiction, letter, and conversations – and distils from them that rare self-help manual: one that is actually helpful.

Clever and ambitious, Emma Jung yearned to study the natural sciences at the University of Zurich. But the strict rules of proper Swiss society at the beginning of the 20th century dictated that a woman of Emma's stature - one of the richest heiresses in Switzerland - travel to Paris to "finish" her education, to prepare for marriage to a suitable man. Engaged to the son of one of her father's wealthy business colleagues, Emma's conventional and predictable life was upended when she met Carl Jung.

Zelda Fitzgerald was the mythical American Dream Girl of the Roaring Twenties who became, in the words of her husband, F. Scott Fitzgerald, "the first American flapper." Their romance transformed a symbol of glamour and spectacle of the Jazz Age. When Zelda cracked up, not long after the stock market crash of 1929, Scott remained loyal to her through a nightmare of later breakdowns and final madness.

In The Butchering Art, the historian Lindsey Fitzharris reveals the shocking world of 19th-century surgery on the eve of profound transformation. She conjures up early operating theaters - no place for the squeamish - and surgeons, working before anesthesia, who were lauded for their speed and brute strength. They were baffled by the persistent infections that kept mortality rates stubbornly high. A young, melancholy Quaker surgeon named Joseph Lister would solve the deadly riddle and change the course of history.

Why do we think, feel, and act in ways we wish we did not? For decades, New York Times best-selling author Dr. David A. Kessler has studied this question with regard to tobacco, food, and drugs. Over the course of these investigations, he identified one underlying mechanism common to a broad range of human suffering. This phenomenon - capture - is the process by which our attention is hijacked and our brains commandeered by forces outside our control.

When Stalin came into power in 1924, the Communist government began persecuting dissident writers. Though Stalin spared the life of Boris Pasternak - whose novel in progress, Doctor Zhivago, was suspected of being anti-Soviet - he persecuted Boris' mistress, typist, and literary muse, Olga Ivinskaya. Boris' affair with Olga devastated the straitlaced Pasternaks, and they were keen to disavow Olga's role in Boris' writing process.

Miller, through Keats’s poetry, brilliantly resurrects and brings vividly to life, the man, the poet in all his complexity and spirit, living dangerously, disdaining respectability and cultural norms, and embracing subversive politics. Keats was a lower-middle-class outsider from a tragic and fractured family, whose extraordinary energy and love of language allowed him to pummel his way into the heart of English literature; a freethinker and a liberal at a time of repression, who delighted in the sensation of the moment.

Adapted by David Mamet from a translation by Vlada Chernornirdik. In this classic of Chekhov’s canon, an overbearing professor pays a visit to his country estate, where Sonya and Vanya, his daughter and former brother-in-law, have slaved to maintain his wealth. But Vanya is enchanted by the professor’s new wife, while Sonya has fallen for the town’s melancholy doctor. Includes a conversation with Rosamund Bartlett, author of Chekhov: Scenes from a Life.

After the untimely death of Prince Albert, the Queen and her nation were plunged into a state of grief so profound that this one event would dramatically alter the shape of the British monarchy. For Britain had not just lost a prince: during his 20-year marriage to Queen Victoria, Prince Albert had increasingly performed the function of King in all but name. The outpouring of grief after Albert's death was so extreme that its like would not be seen again until the death of Princess Diana 136 years later.

You get ready to die the way you get ready for a trip. Start by realizing you don't know the way. Listen to a few travel guides. Study the language, look at maps, gather equipment. Let yourself imagine what it will be like. Pack your bags. This book is one of those travel guides - a guide to preparing for your own death and the deaths of people close to you. The fact of death is hard to believe. Sallie Tisdale explores our fears and all the ways death and talking about death make us uncomfortable - but she also explores its intimacies and joys.