In Blind Spots, Dr. Makary explores the latest research on critical topics ranging from the microbiome to childbirth to nutrition and longevity and more, revealing the biggest blind spots of modern medicine and tackling the most urgent yet unsung issues in our $4.5 trillion health care ecosystem. The path to medical mishaps can be absurd, entertaining, and jaw-dropping—but the truth is essential to our health.

Over thousands of years, the Mississippi watershed was home to millions of Indigenous people who regarded "the great river" with awe and respect, adorning its banks with astonishing spiritual earthworks. But European settlers and American pioneers had a different vision: the river was a foe to conquer. In this landmark work of natural history, Boyce Upholt tells the epic story of human attempts to own and contain the Mississippi River, from Thomas Jefferson's expansionist land hunger through today's era of environmental concern

In The Butchering Art, the historian Lindsey Fitzharris reveals the shocking world of 19th-century surgery on the eve of profound transformation. She conjures up early operating theaters - no place for the squeamish - and surgeons, working before anesthesia, who were lauded for their speed and brute strength. They were baffled by the persistent infections that kept mortality rates stubbornly high. A young, melancholy Quaker surgeon named Joseph Lister would solve the deadly riddle and change the course of history.

On September 11, 1999, humanity made a monumental discovery in the vastness of space. Scientists uncovered an asteroid of immense scientific importance—a colossal celestial entity. As massive as an aircraft carrier and towering as high as the iconic Empire State Building, this cosmic titan was later named Bennu. Remarkable for much more than its size, Bennu belonged to a rare breed of asteroids capable of revealing the essence of life itself. But just as Bennu became a beacon of promise, researchers identified a grave danger.

Scratch beneath the surface of a coffee bean, a red pepper flake, a poppy seed, a mold spore, a foxglove leaf, a magic-mushroom cap, a marijuana bud, or an apple seed, and we find a bevy of strange chemicals. We use these to greet our days (caffeine), titillate our tongues (capsaicin), recover from surgery (opioids), cure infections (penicillin), mend our hearts (digoxin), bend our minds (psilocybin), calm our nerves (CBD), and even kill our enemies (cyanide). But why do plants and fungi produce such chemicals? And how did we come to use and abuse some of them?

Mel Robbins is back! The international bestselling phenomenon and creator of The Five Second Rule and Kick Ass with Mel Robbins returns to help you tackle the single biggest obstacle you face: fear. This life-changing Audible Original features a powerful mix of one-on-one life-coaching sessions and a personal narrative with vital take-aways that you can start using immediately.

Have you ever noticed that when you do something positive to your body, your mood lifts too? Our minds and bodies are more connected than you could ever imagine and the latest science is proving just that. In this podcast, Psychologist Kimberley Wilson explores a range of activities that can help to boost your focus, energy and overall mental wellbeing. And she’ll reveal her easy take-home tips and tricks that you can add to your daily routine to help you get started right away - whether you want to reboot with a nap, take a cold water splash, or reap the benefits of a burst of morning sun.

Are you ready to unlock the greatest resource of your life? Gabby Bernstein has written the ultimate self-help guide, offering a revolutionary practice to radically shift your core beliefs and connect you to an infallible inner guidance system: the energy of Self within you. In this groundbreaking book, Gabby demystifies the power of Internal Family Systems (IFS) Therapy, taking its life-changing teachings out of the therapist’s office and into your everyday life.

Meditation makes you more productive because it lets you earn back time. For each minute you spend meditating, you'll earn around nine minutes back, as Chris Bailey - author of The Productivity Project and Hyperfocus - will show in this candid and counter-intuitive guide to the productivity benefits of meditation.

In this highly listenable and provocative book, Dr. Jason Fung sets out an original, robust theory of obesity that provides startling insights into proper nutrition. In addition to his five basic steps - a set of lifelong habits that will improve your health and control your insulin levels - Dr. Fung explains how to use intermittent fasting to break the cycle of insulin resistance and reach a healthy weight - for good.

In this wide-ranging exploration of animals' inner lives, Keim takes us into courtrooms and wildlife hospitals, under backyard decks and into deserts, to meet anew the wild creatures who populate our communities and the philosophers, rogue pest controllers, ecologists, wildlife doctors, and others who are reimagining our relationships to them.

Because of the diseases it spreads, we have learned to distance ourselves from our waste, but the long line of engineering marvels we’ve created to do so - from Roman sewage systems and medieval latrines to the immense, computerized treatment plants we use today - has also done considerable damage to the Earth’s ecology. Now scientists tell us: We’ve been wasting our waste.

Epidemiologist Steffanie Strathdee and her husband, psychologist Tom Patterson, were vacationing in Egypt when Tom came down with a stomach bug. What at first seemed like a case of food poisoning quickly turned critical, and by the time Tom had been transferred via emergency medevac to the world-class medical center at UC San Diego, where both he and Steffanie worked, blood work revealed why modern medicine was failing: Tom was fighting one of the most dangerous, antibiotic-resistant bacteria in the world.

In the last half of the twentieth century, Don Thomas discovered a cure for every marrow-based disease—like leukemia, lymphoma, and sickle-cell anemia—forever changing treatment for some of the deadliest illnesses. His feats were extraordinary, earning him a Nobel Prize, and the cascade of treatments he inspired have reshaped and will continue to reshape the practice of clinical medicine. Yet no one has ever written Thomas’s courageous story.Dr. Frederick R. Appelbaum, a member of Thomas’s research team, does so for the first time.

Written in taut, urgent prose, Hum is a work of speculative fiction that unflinchingly explores marriage, motherhood, and selfhood in a world compromised by global warming and dizzying technological advancement, a world of both dystopian and utopian possibilities.

When he was six years old, Roger Penrose discovered a sundial in a clearing near his house. Through that machine made of light, shadow, and time, Roger glimpsed a “world behind the world” of transcendently beautiful geometry. It spurred him on a journey to become one of the world’s most influential mathematicians, philosophers, and physicists. Penrose would prove the limitations of general relativity, set a new agenda for theoretical physics, and astound colleagues and admirers with the elegance and beauty of his discoveries.

In The Suggestible Brain, world-renowned expert on the science of suggestion Amir Raz, PhD, brings together cognitive aspects of psychology, sociology, and anthropology with issues in our contemporary culture and media alongside a series of case studies of patients with disorders ranging from Tourette’s syndrome to false pregnancies, lactose intolerance, and asthma to show exactly how suggestions can cut deep into our brains, shake our fundamental knowledge, and override our core human values.

Music is one of humanity’s oldest medicines. From the Far East to the Ottoman Empire, Europe to Africa and the pre-colonial Americas, many cultures have developed their own rich traditions for using sound and rhythm to ease suffering, promote healing, and calm the mind. In his latest work, neuroscientist and New York Times best-selling author Daniel J. Levitin (This Is Your Brain on Music) explores the curative powers of music, showing us how and why it is one of the most potent therapies today.

Cats are mysterious creatures, and the relationship between humans and cats has never been simple. Curious and affectionate, independent and uninterested, predator and prey. Their true nature continues to elude us, and their subtle and complex behavioral problems can often seem unsolvable or incomprehensible. So, how can we tell if a cat is suffering? What are the root causes of feline aggression? And how can we treat patients who can’t speak for themselves?

In Continental Reckoning renowned historian Elliott West presents a sweeping narrative of the American West and its vital role in the transformation of the nation. In the 1840s, by which time the United States had expanded to the Pacific, what would become the West was home to numerous vibrant Native cultures and vague claims by other nations.

Robbers Roost, Brown’s Hole, and Hole-in-the-Wall were three hideouts that collectively were known to outlaws as “Bandit Heaven.” During the 1880s and ‘90s these remote locations in Wyoming and Utah harbored hundreds of train and bank robbers, horse and cattle thieves, the occasional killer, and anyone else with a price on his head.

“Even now, nearly a century after her death, Marie Curie remains the only female scientist most people can name,” writes Dava Sobel at the opening of her shining portrait of the sole Nobel laureate decorated in two separate fields of science—Physics in 1903 with her husband Pierre and Chemistry by herself in 1911. And yet, Sobel makes clear, as brilliant and creative as she was in the laboratory, Marie Curie was equally passionate outside it.

We are living through a revolution in machine learning-powered AI that shows no signs of slowing down. This technology is based on relatively simple mathematical ideas, some of which go back centuries, including linear algebra and calculus, the stuff of seventeenth- and eighteenth-century mathematics. It took the birth and advancement of computer science and the kindling of 1990s computer chips designed for video games to ignite the explosion of AI that we see today. In this enlightening book, Anil Ananthaswamy explains the fundamental math behind machine learning.

Follow the Science recounts, in exacting detail, how far the pharmaceutical industry and its supporters in medicine, media, and government will go to protect their profits. Attkisson provides shocking examples that reveal the disturbing callousness our government, public health officials, and top researchers are capable of when it comes to the most vulnerable among us. And she explains, in a graphic sense, how some of the most trusted within our society are willing to commit life-threatening ethics violations.

George Smiley has left the Circus. With the wreckage of the West’s spy war against the Soviets strewn across Europe, he has eyes only for a more peaceful life. And indeed, with his marriage more secure than ever, there is a rumor that George Smiley might almost be happy. But Control has other plans. A Russian agent has defected in the most unusual of circumstances, and the man he was sent to kill in London is nowhere to be found. Smiley reluctantly agrees to one last simple task: interview Szusanna, a Hungarian émigré and employee of the missing man, and sniff out a lead.