Rachel Stoltzfus never imagined she’d be the talk of her Old Order Mennonite community until whispers stir the moment her belly swells with new life. Unmarried and refusing to repent by naming the partner in her sin, Rachel feels the wrath of the religious sect as she is shunned by those she loves most and eventually forced to leave - driven out by her twin sister’s husband, the bishop. But secrets run deep in this cloistered community, and the bishop is hiding some of his own, threatening his conscience and his very soul.

For nearly 200 years, women in Ashley Tolliver's family have practiced the art of midwifery in their mountain community. Now she wants to take her skills a step further, but attending medical school means abandoning those women to whom she has dedicated her life, the mountains she loves, and the awakening of her heart.

When Ruth Neufeld's husband and father-in-law are killed working for a relief organization overseas, she travels to Wisconsin with her young daughters and mother-in-law, Mabel, to bury her husband. She hopes the Mennonite community will be a quiet place to grieve and piece together next steps.

Midwife Patience Murphy has a gift: a talent for escorting mothers through the challenges of bringing children into the world. Working in the hardscrabble conditions of Appalachia during the Depression, Patience takes the jobs that no one else wants, helping those most in need - and least likely to pay. She knows a successful midwifery practice must be built on a foundation of openness and trust - but the secrets Patience is keeping are far too intimate and fragile for her to ever let anyone in.

When Leora Ebersole sees the small plane crash in her Old Order Mennonite community, she has no idea it's a foreshadowing of things to come. Soon after the young pilot, Moses Hughes, regains consciousness, they realize his instruments were destroyed by the same power outage that killed the electricity at the community store, where Englischers are stranded with dead cell phones and cars that won't start.

Ten years ago, Izzy Stone's mother fatally shot her father while he slept. Devastated by her mother's apparent insanity, Izzy, now 17, refuses to visit her in prison. But her new foster parents, employees at the local museum, have enlisted Izzy's help in cataloguing items at a long-shuttered state asylum. There, amid piles of abandoned belongings, Izzy discovers a stack of unopened letters, a decades-old journal, and a window into her own past.

Peggy Serrano couldn’t wait for her best friend to come home from the war. But the Jimmy Barnett who returns is much different from the Jimmy who left, changed so drastically by his experience as a medic in Europe that he can barely function. When he attempts the unthinkable, his parents check him into the VA hospital. Peggy determines to help the Barnetts unravel what might have happened to send their son over the edge. She starts by contacting Jimmy’s war buddies, trying to identify the mysterious woman in the photo they find in Jimmy’s belongings.

Colorado, 1880. Gracy Brookens has delivered hundreds, maybe thousands of babies in her lifetime. The only midwife in a small mining town tucked in the Tenmile Range, Gracy is a gifted and important resource for the women of her hardscrabble community. For years she has advised expectant mothers through their pregnancies, guided them through the tortures of labor, and then helped them heal.

Memphis, 1939. Twelve-year-old Rill Foss and her four younger siblings live a magical life aboard their family’s Mississippi River shantyboat. But when their father must rush their mother to the hospital one stormy night, Rill is left in charge - until strangers arrive in force. Wrenched from all that is familiar and thrown into a Tennessee Children’s Home Society orphanage, the Foss children are assured that they will soon be returned to their parents - but they quickly realize the dark truth.

As the war begins, Hanna Rombauer, a young German woman, is sent to live with her aunt and uncle after her mother’s death. Thrown into a life of luxury she never expected, Hanna soon finds herself unwillingly matched with an SS officer twenty years her senior. The independence that her mother lovingly fostered in her is considered highly inappropriate as the future wife of an up-and-coming officer and she is sent to a “bride school.” There, in a posh villa on the outskirts of town, Hanna is taught how to be a “proper” German wife.

Ana Kaminski is pushed through the iron gates of Auschwitz beside her frightened young friend Ester Pasternak. As they reach the front of the line, Ana steps forward and quietly declares herself a midwife--and Ester her assistant. Their arms are tattooed and they’re ordered to the maternity hut. Holding an innocent newborn baby, Ana knows the fate of so many are in her hands and vows to do everything she can to save them.

When six-year-old Alice Hilton disappears on New Year's Eve 1979 from Yew Tree Manor, suspicion immediately falls on local boy Bobby James. Bobby claims he knows nothing about it, but his family has a grievance against Alice's landowner father. Tragically the child is never found. Decades later, Willow James, an architect working on a development at Yew Tree Manor, discovers that the land surrounding the house is holding a secret.

Neva Bradley, a third-generation midwife, is determined to keep the details surrounding her own pregnancy - including the identity of the baby's father - hidden from her family and co-workers for as long as possible. Her mother Grace finds it impossible to let this secret rest. The more Grace prods, the tighter Neva holds to her story, and the more the lifelong differences between private, quiet Neva and open, gregarious Grace strain their relationship.

Penobscot Indian Molly Ayer is close to "aging out" out of the foster care system. A community-service position helping an elderly woman clean out her home is the only thing keeping Molly out of juvie and worse.... As she helps Vivian sort through her possessions and memories, Molly learns that she and Vivian aren’t as different as they seem to be. A young Irish immigrant orphaned in New York City, Vivian was put on a train to the Midwest with hundreds of other children whose destinies would be determined by luck and chance.

The McKenzie women, empowered with a formidable history rooted in the foothills of Appalachia, have passed down their folk-healing wisdom through generations. Rosalee, the last living headstrong daughter in Granny McKenzie’s line, soaked up everything she could about the secrets of the forest before a series of tragedies left her alone, without the protection of the women who came before her.