
The Power of Prions
The Strange and Essential Proteins That Can Cause Alzheimer’s, Parkinson’s, and Other Diseases
Failed to add items
Add to Cart failed.
Add to Wish List failed.
Remove from wishlist failed.
Adding to library failed
Follow podcast failed
Unfollow podcast failed

Get 2 free audiobooks during trial.
Buy for $11.17
No default payment method selected.
We are sorry. We are not allowed to sell this product with the selected payment method
-
Narrated by:
-
Mike Cooper
-
By:
-
Michel Brahic
About this listen
Over the last decade, scientists have discovered the importance and widespread presence in the body of a remarkable family of proteins known as prion proteins. Research links various types of prion proteins to neurodegenerative diseases such as Parkinson's and Alzheimer's—and this has fueled the search for new drugs that could halt the progression of these terrible disorders. Other discoveries have revealed the essential roles prion proteins play in memory and immunity, and the part they may have played in the beginnings of life on our planet.
Brahic, a leading researcher on diseases of the central nervous system, first describes the discovery of prions and their role in infection, beginning with early work on the animal disease scrapie and a mysterious human illness in New Guinea, apparently transmitted by cannibalism. Prion proteins were then revealed as the cause of other illnesses, from "mad cow" disease and its human counterpart, Creutzfeldt-Jakob disease, to such noninfectious brain disorders as Parkinson's and Alzheimer's. While the prion proteins responsible for diseases are definitively "bad," Brahic also explains that these abnormal prions are rare exceptions. Most of the time, prion proteins actually serve "good" and vital functions—and they may even have been present at the origin of life itself.
©2024 Michel Brahic (P)2024 TantorListeners also enjoyed...
-
Life as No One Knows It
- The Physics of Life's Emergence
- By: Sara Imari Walker
- Narrated by: Sara Imari Walker
- Length: 7 hrs and 20 mins
- Unabridged
-
Overall
-
Performance
-
Story
What is life? This is among the most difficult open problems in science, right up there with the nature of consciousness and the existence of matter. All the definitions we have fall short. None help us understand how life originates or the full range of possibilities for what life on other planets might look like. In Life as No One Knows It, physicist and astrobiologist Sara Imari Walker argues that solving the origin of life requires radical new thinking and an experimentally testable theory for what life is.
-
-
Fascinating thought patterns
- By John linden on 09-10-24
-
Space Oddities
- The Mysterious Anomalies Challenging Our Understanding of the Universe
- By: Harry Cliff
- Narrated by: Harry Cliff
- Length: 7 hrs and 51 mins
- Unabridged
-
Overall
-
Performance
-
Story
Something strange is going on in the cosmos. Scientists are uncovering a catalogue of weird phenomena that simply can’t be explained by our long-established theories of the universe. After decades of fruitless searching, could we finally be catching glimpses of a profound new view of our physical world? Or are we being fooled by cruel tricks of the data? In Space Oddities, Harry Cliff, a physicist who does cutting-edge work on the Large Hadron Collider, provides a riveting look at the universe’s most confounding puzzles.
-
-
as compelling as a mystery novel and very informative
- By jimpgh@aol.com on 04-22-24
By: Harry Cliff
-
Patient Zero
- A Curious History of the World's Worst Diseases
- By: Lydia Kang MD, Nate Pedersen
- Narrated by: Hillary Huber
- Length: 14 hrs and 17 mins
- Unabridged
-
Overall
-
Performance
-
Story
From the masters of storytelling-meets-science, Patient Zero tells the long and fascinating history of disease outbreaks—how they start, how they spread, the science that lets us understand them, and how we race to destroy them before they destroy us. Written in the authors’ lively style, chapters include gripping medical stories about a particular disease or virus—smallpox, Bubonic plague, polio, HIV—that combine “Patient Zero” narratives, or the human stories behind outbreaks, with historical examinations of missteps, milestones, scientific theories, and more.
-
-
Can’t listen to the reader
- By Doug Clyde on 07-21-22
By: Lydia Kang MD, and others
-
Oathbreakers
- The War of Brothers That Shattered an Empire and Made Medieval Europe
- By: Matthew Gabriele, David M. Perry
- Narrated by: Paul Bellantoni
- Length: 9 hrs and 48 mins
- Unabridged
-
Overall
-
Performance
-
Story
By the early ninth century, the Carolingian empire was at the height of its power. The Franks, led by Charlemagne, had built the largest European domain since Rome in its heyday. Though they jockeyed for power, prestige, and profit, the Frankish elites enjoyed political and cultural consensus. But just two generations later, their world was in shambles. Civil war, once an unthinkable threat, had erupted after Louis the Pious’s sons tried to overthrow him—and then placed their knives at the other’s neck. Families who had once charged into battle together now drew each other’s blood.
-
-
History made amusing
- By Avox on 12-18-24
By: Matthew Gabriele, and others
-
The Great River
- The Making and Unmaking of the Mississippi
- By: Boyce Upholt
- Narrated by: Gabriel Vaughan
- Length: 10 hrs and 18 mins
- Unabridged
-
Overall
-
Performance
-
Story
Over thousands of years, the Mississippi watershed was home to millions of Indigenous people who regarded "the great river" with awe and respect, adorning its banks with astonishing spiritual earthworks. But European settlers and American pioneers had a different vision: the river was a foe to conquer. In this landmark work of natural history, Boyce Upholt tells the epic story of human attempts to own and contain the Mississippi River, from Thomas Jefferson's expansionist land hunger through today's era of environmental concern
-
-
a great summation of the Great River
- By Michael H. Link on 07-27-24
By: Boyce Upholt
-
Memories, Dreams, Reflections
- By: C. G. Jung
- Narrated by: James Cameron Stewart
- Length: 16 hrs and 51 mins
- Unabridged
-
Overall
-
Performance
-
Story
In 1957, four years before his death, Carl Gustav Jung, psychiatrist and psychologist, began writing his life story. But what started as an exercise in autobiography soon morphed into an altogether more profound undertaking. The result is an absorbing piece of self-analysis: a frank statement of faith, philosophy, and principles from one of the great explorers of the human mind.
-
-
My favorite Audible production so far
- By Gaggleframpf on 05-03-16
By: C. G. Jung
-
Life as No One Knows It
- The Physics of Life's Emergence
- By: Sara Imari Walker
- Narrated by: Sara Imari Walker
- Length: 7 hrs and 20 mins
- Unabridged
-
Overall
-
Performance
-
Story
What is life? This is among the most difficult open problems in science, right up there with the nature of consciousness and the existence of matter. All the definitions we have fall short. None help us understand how life originates or the full range of possibilities for what life on other planets might look like. In Life as No One Knows It, physicist and astrobiologist Sara Imari Walker argues that solving the origin of life requires radical new thinking and an experimentally testable theory for what life is.
-
-
Fascinating thought patterns
- By John linden on 09-10-24
-
Space Oddities
- The Mysterious Anomalies Challenging Our Understanding of the Universe
- By: Harry Cliff
- Narrated by: Harry Cliff
- Length: 7 hrs and 51 mins
- Unabridged
-
Overall
-
Performance
-
Story
Something strange is going on in the cosmos. Scientists are uncovering a catalogue of weird phenomena that simply can’t be explained by our long-established theories of the universe. After decades of fruitless searching, could we finally be catching glimpses of a profound new view of our physical world? Or are we being fooled by cruel tricks of the data? In Space Oddities, Harry Cliff, a physicist who does cutting-edge work on the Large Hadron Collider, provides a riveting look at the universe’s most confounding puzzles.
-
-
as compelling as a mystery novel and very informative
- By jimpgh@aol.com on 04-22-24
By: Harry Cliff
-
Patient Zero
- A Curious History of the World's Worst Diseases
- By: Lydia Kang MD, Nate Pedersen
- Narrated by: Hillary Huber
- Length: 14 hrs and 17 mins
- Unabridged
-
Overall
-
Performance
-
Story
From the masters of storytelling-meets-science, Patient Zero tells the long and fascinating history of disease outbreaks—how they start, how they spread, the science that lets us understand them, and how we race to destroy them before they destroy us. Written in the authors’ lively style, chapters include gripping medical stories about a particular disease or virus—smallpox, Bubonic plague, polio, HIV—that combine “Patient Zero” narratives, or the human stories behind outbreaks, with historical examinations of missteps, milestones, scientific theories, and more.
-
-
Can’t listen to the reader
- By Doug Clyde on 07-21-22
By: Lydia Kang MD, and others
-
Oathbreakers
- The War of Brothers That Shattered an Empire and Made Medieval Europe
- By: Matthew Gabriele, David M. Perry
- Narrated by: Paul Bellantoni
- Length: 9 hrs and 48 mins
- Unabridged
-
Overall
-
Performance
-
Story
By the early ninth century, the Carolingian empire was at the height of its power. The Franks, led by Charlemagne, had built the largest European domain since Rome in its heyday. Though they jockeyed for power, prestige, and profit, the Frankish elites enjoyed political and cultural consensus. But just two generations later, their world was in shambles. Civil war, once an unthinkable threat, had erupted after Louis the Pious’s sons tried to overthrow him—and then placed their knives at the other’s neck. Families who had once charged into battle together now drew each other’s blood.
-
-
History made amusing
- By Avox on 12-18-24
By: Matthew Gabriele, and others
-
The Great River
- The Making and Unmaking of the Mississippi
- By: Boyce Upholt
- Narrated by: Gabriel Vaughan
- Length: 10 hrs and 18 mins
- Unabridged
-
Overall
-
Performance
-
Story
Over thousands of years, the Mississippi watershed was home to millions of Indigenous people who regarded "the great river" with awe and respect, adorning its banks with astonishing spiritual earthworks. But European settlers and American pioneers had a different vision: the river was a foe to conquer. In this landmark work of natural history, Boyce Upholt tells the epic story of human attempts to own and contain the Mississippi River, from Thomas Jefferson's expansionist land hunger through today's era of environmental concern
-
-
a great summation of the Great River
- By Michael H. Link on 07-27-24
By: Boyce Upholt
-
Memories, Dreams, Reflections
- By: C. G. Jung
- Narrated by: James Cameron Stewart
- Length: 16 hrs and 51 mins
- Unabridged
-
Overall
-
Performance
-
Story
In 1957, four years before his death, Carl Gustav Jung, psychiatrist and psychologist, began writing his life story. But what started as an exercise in autobiography soon morphed into an altogether more profound undertaking. The result is an absorbing piece of self-analysis: a frank statement of faith, philosophy, and principles from one of the great explorers of the human mind.
-
-
My favorite Audible production so far
- By Gaggleframpf on 05-03-16
By: C. G. Jung