We the Scientists
How a Daring Team of Parents and Doctors Forged a New Path for Medicine
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Narrated by:
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Kristen DiMercurio
About this listen
A Pulitzer Prize-winning reporter’s moving narrative of a group of patient advocates who are revolutionizing the way medical research is conducted.
For more than half a century, medical advances have been driven by investigators launching experiments inside labs. Science is often conducted in isolation and geared toward the long view. This is the story of a group of people who tried to force the lab doors open: parents whose children had been diagnosed with a rare and fatal genetic condition known as Niemann-Pick disease type C. The disease prevents cells from processing cholesterol, which leads to the progressive loss of the brain’s and the body’s ability to function. Recognizing that there would never be a treatment in time to save their children if things stayed the same, the parents set up a collaboration with researchers and doctors in search of a cure.
Reconciling different views of science took work. The parents, doctors, and researchers didn't always agree—among themselves or with each other. But together they endeavored to accelerate the development of new drugs. The parents became citizen scientists, identifying promising new treatments and helping devise experiments. They recorded data about the children and co-authored scientific papers sharing findings. They engaged directly with the FDA at each step of the drug approval process. Along the way, they advanced the radical idea that science must belong to us all.
Amy Dockser Marcus shows what happens when a community joins forces with doctors and researchers to try to save children’s lives. Their extraordinary social experiment reveals new pathways for treating disease and conducting research. Science may be forever changed.
©2023 Amy Dockser Marcus (P)2023 Penguin AudioListeners also enjoyed...
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Critic reviews
“An absorbing narrative…Through details of perseverance, courage, and grace, frustration is ultimately eclipsed in We the Scientists by another theme. It is the name for the NIH drug discovery robots proposed by one of the parents: Hope.” —Science
“This book illuminates the painful tension between the extended time frames of medical research and the life spans of those hoping for a cure. . . . Marcus shows how parents, by imparting a sense of urgency to the search for a cure, have helped future generations of children even as they could not save their own.” —The New Yorker
“The story of a painful but inspiring search for a cure for a fatal disease.…A moving argument for a more focused, humane, and efficient system for conducting medical research.” —Kirkus (STARRED REVIEW)
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Story
In the spring of 2020, COVID-19 arrived in New York City. Before long, America’s largest metropolis was at war against a virus that mercilessly swept through its five boroughs. In The Desperate Hours, award-winning journalist Marie Brenner, having been granted unprecedented 18-month access to the entire New York-Presbyterian hospital system, tells the story of the doctors, nurses, residents, researchers, and suppliers who tried to save lives across Manhattan, Queens, and Brooklyn and the northern periphery of the city.
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Way too much politics
- By Josh on 07-18-22
By: Marie Brenner
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Beating Back the Devil
- By: Maryn McKenna
- Narrated by: Ellen Archer
- Length: 9 hrs and 37 mins
- Unabridged
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The universal instinct is to run from an outbreak of disease. These doctors run toward it. They always keep a bag packed. They seldom have more than 24 hours before they are dispatched. They are told only their country of destination and the epidemic they will tackle when they get there.
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Interesting Stuff - Only criticism is pacing
- By Tim on 07-23-05
By: Maryn McKenna
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Doctored
- The Disillusionment of an American Physician
- By: Sandeep Jauhar
- Narrated by: Patrick Lawlor
- Length: 10 hrs and 38 mins
- Unabridged
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Hoping for the stability he needs to start a family, Sandeep Jauhar, an attending cardiologist, accepts a position at a massive teaching hospital on the outskirts of Queens. With a decade's worth of elite medical training behind him, he is eager to settle down and reap the rewards of countless sleepless nights. Instead, he is confronted with sobering truths. Doctors' morale is low and getting lower.
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Frank, inside perspective on the follies of unintended consequences in medical reform
- By JW on 02-25-18
By: Sandeep Jauhar
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The Family Gene
- A Mission to Turn My Deadly Inheritance into a Hopeful Future
- By: Joselin Linder
- Narrated by: Khristine Hvam
- Length: 7 hrs and 17 mins
- Unabridged
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When Joselin Linder was in her 20s, her legs started to swell. She thought little of it until her health problems started to compound in ways that baffled her doctors. Diagnosed with extreme liver blockage and dangerous levels of lymph fluid, Joselin turned to the most similar case she could think of - her father's.
By: Joselin Linder
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Splendid Solution
- Jonas Salk and the Conquest of Polio
- By: Jeffrey Kluger
- Narrated by: Michael Prichard
- Length: 13 hrs and 12 mins
- Unabridged
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Salk became a cultural hero and icon for a whole generation. Now, at the fiftieth anniversary of the first national vaccination program, and as humanity is tantalizingly close to eradicating polio worldwide, comes this unforgettable chronicle. Salk's work was an unparalleled achievement, and it makes for a magnificent listen.
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Excellent book
- By Tim on 08-10-06
By: Jeffrey Kluger
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Your Heart, My Hands
- An Immigrant's Remarkable Journey to Become One of America's Preeminent Cardiac Surgeons
- By: Arun K. Singh MD, John Hanc - contributor, Delos Cosgrove MD - foreword
- Narrated by: Shridhar Solanki
- Length: 8 hrs and 39 mins
- Unabridged
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Leaving a life marked by crippling setbacks and his father's doubt, in 1967 a 20-something doctor from India arrived in America with only five dollars and the desire to claim his American dream. Faced with an entirely new culture, racism, and the lasting effects of disabling childhood injuries, through hard work and perseverance he overcame all odds. Now having performed over 15,000 open-heart surgeries, more than nearly every surgeon in history, Dr. Singh reflects on his most memorable patients and his incredible personal life.
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Remarkable!
- By Stacey on 12-01-22
By: Arun K. Singh MD, and others
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God's Hotel
- A Doctor, a Hospital, and a Pilgrimage to the Heart of Medicine
- By: Victoria Sweet
- Narrated by: Victoria Sweet
- Length: 13 hrs and 44 mins
- Unabridged
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San Francisco's Laguna Honda Hospital is the last almshouse in the country, a descendant of the Hôtel-Dieu (God's hotel) that cared for the sick in the Middle Ages. Ballet dancers and rock musicians, professors and thieves - "anyone who had fallen, or, often, leapt, onto hard times" and needed extended medical care - ended up here. So did Victoria Sweet, who came for two months and stayed for 20 years. Laguna Honda, lower-tech but human-paced, gave Sweet the opportunity to practice a kind of attentive medicine that has almost vanished.
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Great read
- By kayla solomon on 04-08-17
By: Victoria Sweet
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A Bittersweet Season
- Caring for Our Aging Parents - And Ourselves
- By: Jane Gross
- Narrated by: Kate Reading
- Length: 15 hrs and 35 mins
- Unabridged
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In telling the intimate story of caring for her aged and ailing mother, Jane Gross offers indispensable, and often surprising, advice for the rapidly increasing number of adult children responsible for aging parents. Gross deftly weaves the specifics of her personal experience with a comprehensive resource for effectively managing the lives of one's own parents while keeping sanity and strength intact.
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Exceptional, thought-provoking, liberating!
- By Anne on 08-10-11
By: Jane Gross
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When Breath Becomes Air
- By: Paul Kalanithi, Abraham Verghese - foreword
- Narrated by: Sunil Malhotra, Cassandra Campbell
- Length: 5 hrs and 35 mins
- Unabridged
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At the age of thirty-six, on the verge of completing a decade’s worth of training as a neurosurgeon, Paul Kalanithi was diagnosed with stage IV lung cancer. One day he was a doctor treating the dying, and the next he was a patient struggling to live. And just like that, the future he and his wife had imagined evaporated.
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Phenomenal book!
- By A. Potter on 01-16-16
By: Paul Kalanithi, and others
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One Doctor
- Close Calls, Cold Cases, and the Mysteries of Medicine
- By: Brendan Reilly
- Narrated by: Rob Shapiro
- Length: 15 hrs and 7 mins
- Unabridged
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An epic story told by a unique voice in American medicine, One Doctor describes life-changing experiences in the career of a distinguished physician. In riveting first-person prose, Dr. Brendan Reilly takes us to the front lines of medicine today.
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Simply Brilliant
- By Jan on 06-20-14
By: Brendan Reilly
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Epic Measures
- One Doctor. Seven Billion Patients.
- By: Jeremy N. Smith
- Narrated by: Patrick Lawlor
- Length: 10 hrs and 12 mins
- Unabridged
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Moneyball meets medicine in this remarkable chronicle of one of the greatest scientific quests of our time - the groundbreaking program to answer the most essential question for humanity: How do we live and die? - and the visionary mastermind behind it.
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Fabulously insightful read!
- By Dr. Jack E. Fincham on 10-08-15
By: Jeremy N. Smith
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How Doctors Think
- By: Jerome Groopman M.D.
- Narrated by: Michael Prichard
- Length: 10 hrs and 27 mins
- Unabridged
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On average, a physician will interrupt a patient describing her symptoms within 12 seconds. In that short time, many doctors decide on the likely diagnosis and best treatment. Often, decisions made this way are correct, but at crucial moments they can also be wrong: with catastrophic consequences. In this myth-shattering book, Jerome Groopman pinpoints the forces and thought processes behind the decisions doctors make.
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Disappointing
- By Audiophile on 05-13-07
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Teeth
- The Story of Beauty, Inequality, and the Struggle for Oral Health in America
- By: Mary Otto
- Narrated by: Suehyla El'Attar
- Length: 9 hrs and 37 mins
- Unabridged
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Teeth takes listeners on a disturbing journey into America's silent epidemic of oral disease, exposing the hidden connections between tooth decay and stunted job prospects, low educational achievement, social mobility, and the troubling state of our public health.
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Content everyone should know; dismal narration
- By Elaine on 08-04-17
By: Mary Otto
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Early
- An Intimate History of Premature Birth and What It Teaches Us About Being Human
- By: Sarah DiGregorio
- Narrated by: Ann Marie Gideon
- Length: 9 hrs and 47 mins
- Unabridged
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The heart of many hospitals is the Neonatal Intensive Care Unit (NICU). It is a place where humanity, ethics, and science collide in dramatic and deeply personal ways as parents, doctors, and nurses grapple with sometimes unanswerable questions: When does life begin? When and how should life end? And what does it mean to be human? Nearly 20 years ago, Dr. John D. Lantos wrote The Lazarus Case, a seminal work on ethical dilemmas in neonatology. He described the NICU as “a strong, strange, powerful place”. The
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Gripping read for this late preterm infant mom
- By R. Ash on 08-08-21
By: Sarah DiGregorio
What listeners say about We the Scientists
Average customer ratingsReviews - Please select the tabs below to change the source of reviews.
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- Kendall G
- 03-28-23
Changes to The Status Quo
I like nearly anything to do with medicine, that’s the industry I work in. So there’s my bias. Now, this book is really about David & Goliath, metaphorically. It’s about what parents will do for their children and then how that live spreads to helping others. Good, healthy, fun read
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- Future
- 02-15-23
A scientist reviewer
Superbly done with a vision we need. Marcus gives the human perspective on the most human of endeavors: helping one another. Her science is spot on, her compassion is the driving force. Read it.
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2 people found this helpful