Follow the desperate journey of a scientist who will stop at nothing to save the woman he loves from a disease that is slowly consuming her body. But his actions have unintended consequences that plunge the world into a bloody and chaotic apocalypse, where the living are outnumbered by the ravenous, superhuman zombies that roam the streets.

Army veteran Lee Riker is staying in an Atlanta shelter and supporting himself with the odd carpentry job when his sister, Tara, summons him home to Indiana for the reading of their mother’s will. Riker boards a Greyhound bus in Atlanta with his duffel bag, less than $200 to his name, and a secret he must protect at all costs. Riker makes it to Middletown only to learn his sister has recently witnessed a gruesome death. Insisting she saw the victim rise from a pool of his own blood to attack the Samaritan rendering aid, Tara floats the idea that the man may have been a zombie.

Will Kessler works a dead-end warehouse job in Tennessee, driving a forklift and unloading shipping containers. When he wakes up from a nap during his lunch break, he finds most of his co-workers have mutated into monsters, and they have turned the 50,000 square foot building into a war zone, murdering any other survivors. Alone and weaponless, Will must fight through the undead horde to secure the building and answer one question: Is he truly alone?

Three years after an incurable virus spread and turned a majority of the population into mindless and cannibalistic creatures, the world is a barren place. Society is broken, and most who remain have banded together in small camps and communities. Jon South is not like most other survivors. After losing his wife and son nearly two years into the pandemic, Jon now wanders the country roads and woods of rural Tennessee, a vigilante taking his revenge out on the undead monsters that took his family from him.

When the black rain began to fall, it was a worldwide phenomenon that mystified everyone. There was little time to ponder the cause. Most animals died at the onset. While some humans were unaffected, others experienced a half-death of sorts, morphing into blood and flesh-crazed creatures with a desire to hunt the living. Climbing Fox Wattana of the Henomawi Nation claims responsibility for the black rain; he says it will will ensure the ultimate extinction of the United States government as revenge for robbing his people of their land. Cole "CB" Baxter isn't taking this lying down.