Chasing the dragon, trying to recreate the first high. After the episode on chandler and his ketamine related death, Wip asked JP questions about ketamine and tolerance based on his past history of personal use. While there are differences in the use if ketamine for depression vs addiction, for some people, self titration to effect is not realistic. Medicine also has history of iatrogenic harms caused by prescribed drugs. We hope this conversation is interesting for you and we look forward to hearing your feedback and thoughts. In this engaging addiction medicine podcast episode, our hosts delve deep into the world of addiction, tolerance, and its various facets. They discuss the concept of "chasing the dragon," where individuals continuously pursue the euphoric sensation of their initial high, drawing parallels to addiction dynamics. The hosts candidly reflect on their own experiences and perspectives, highlighting the importance of curiosity and empathy in understanding addiction. Table of Contents 00:00 "Chasing the Dragon" What is "chasing the dragon," and how does it relate to addiction? Exploring the persistent pursuit of the initial high. The impact of chasing the dragon on individuals and their struggles. 01:40 "The Relevance of Tolerance" How does tolerance play a crucial role in addiction? Differentiating between tolerance and its effects on various substances. Why tolerance matters and its implications for treatment and recovery. 04:40 "Routes of Administration and Absorption" Examining the significance of different administration methods. IV, intranasal, and oral absorption: What are the differences? How absorption rates affect tolerance and addiction potential. 05:38 "Understanding Vulnerability" Why do some individuals have a unique response to substances? Unpacking the experiences of those who feel a positive impact from opiates or ketamine. The importance of recognizing individual differences in addiction risk. This thought-provoking podcast episode offers valuable insights into addiction, tolerance, and the complexities surrounding substance use disorders. Join the hosts as they navigate these topics with empathy, curiosity, and a genuine desire to promote understanding and awareness in the field of addiction medicine. Featuring addiction psychiatrist Dr. Wiplove (Wip) Lamba, addictions case manager and former addict Jean-Paul (JP) Michael, along with their guests discuss all things related to substance use, addiction, addiction medicine, psychotherapy, harm reduction, treatment and recovery. Wip and JP share their motivation, curiosity, and passion for their craft. JP works on a daily basis in a renown inner city hospital in Canada's largest city. This work is separate from Wiplove’s clinical and academic work. The content should not be taken as direct medical advice or clinical instruction.