Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Tolebrutinib in Nonrelapsing Secondary Progressive Multiple Sclerosis

Tolebrutinib versus Teriflunomide in Relapsing Multiple Sclerosis

Journal of American Medical Association

Spironolactone vs Amiloride for Resistant Hypertension

Annals of Internal Medicine

Medical, Societal, and Ethical Considerations for Directed Blood Donation in 2025

British Medical Journal

Use of gabapentinoid treatment and the risk of self-harm: population based self-controlled case series study

Lancet

Clinical presentation and epidemiological assessment of confirmed human mpox cases in DR Congo: a surveillance-based observational study

journal of Hepatology

A new generation of non-invasive tests of liver fibrosis with improved accuracy in MASLD

Gastroenterology

Physiological Data Collected From Wearable Devices Identify and Predict Inflammatory Bowel Disease Flares

Clinical Gastroenterology

Reproducibility of the AGREE II Tool for Assessing the Methodological Quality of Clinical Practice Guidelines for the Management of Antithrombotic Agents in Patients Undergoing GI Endoscopy

Circulation

Genetic and Lifestyle Risks for Coronary Artery Disease and Long-Term Risk of Incident Dementia Subtypes

Journals of the American College of Cardiology

Ischemia on Dobutamine Stress Echocardiography Predicts Efficacy of PCI: Results From the ORBITA-2 Trial

JAMA Cardiology

Trajectory of Cardiovascular Health Across Childhood and Adolescence

Journal of Clinical Endocrinology & Metabolism

Renal Protective Effect of Metformin in Type 2 Diabetes Patients

Diabetes care

Efficacy and Safety of Finerenone in Type 2 Diabetes: A Pooled Analysis of Trials of Heart Failure and Chronic Kidney Disease

Neurology

Endovascular Thrombectomy for Large Ischemic Core Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Chest

Effect of Flow Rates of High-Flow Nasal Cannula on Extubation Outcomes

The American Journal of Respiratory and Critical Care Medicine

Clinical and Biological Features of a Thickened Basement Membrane Zone in Asthma

Clinical Journal of American Society of Nephrology

Dialysis Dependence in Standard versus Accelerated Initiation of KRT in AKI: A Post Hoc Analysis

Kidney International reports

Scoping Review of Kidney Patients and Providers Perspectives on Disaster Management