Drs Gail Roboz and Farhad Ravandi discuss acute promyelocytic leukemia, a relatively uncommon subset of acute myeloid leukemia.

Relevant disclosures can be found with the episode show notes on Medscape.com (https://www.medscape.com/viewarticle/964529). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

High Prevalence of Obesity in Acute Promyelocytic Leukemia (APL): Implications for Differentiating Agents in APL and Metabolic Syndrome https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573402/pdf/10.1177_2040620711408490.pdf

High Frequency of Acute Promyelocytic Leukemia Among Latinos With Acute Myeloid Leukemia https://www.sciencedirect.com/science/article/pii/S0006497120662218?via%3Dihub

Improved Outcomes With Retinoic Acid and Arsenic Trioxide Compared With Retinoic Acid and Chemotherapy in Non-High-Risk Acute Promyelocytic Leukemia: Final Results of the Randomized Italian-German APL0406 Trial https://air.unimi.it/handle/2434/429739

Effective Treatment of Acute Promyelocytic Leukemia With All-Trans-Retinoic Acid, Arsenic Trioxide, and Gemtuzumab Ozogamicin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881307/

All-Trans-Retinoic Acid, Idarubicin, and IV Arsenic Trioxide as Initial Therapy in Acute Promyelocytic Leukemia (APML4) https://ashpublications.org/blood/article/120/8/1570/30826/All-trans-retinoic-acid-idarubicin-and-IV-arsenic

Resistance to Arsenic Trioxide and Retinoic Acid Therapy in Acute Promyelocytic Leukemia https://link.springer.com/article/10.1007/s00277-017-2923-z

Relationship Between FLT3 Mutation Status, Biologic Characteristics, and Response to Targeted Therapy in Acute Promyelocytic Leukemia https://ashpublications.org/blood/article/106/12/3768/109752/Relationship-between-FLT3-mutation-status-biologic