What do you do when there are little data to guide your decision-making? Tune in to hear Drs Felicia Chow, Regan R. Solomons and Kelly E. Dooley discuss managing complicated cases of TBM.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/985911). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Comparative Effectiveness of Regimens for Drug-Susceptible Tuberculous Meningitis in Children and Adolescents: A Systematic Review and Aggregate-Level Data Meta-Analysis https://pubmed.ncbi.nlm.nih.gov/35673608/

Shortened Tuberculosis Treatment Regimens: What Is New? https://pubmed.ncbi.nlm.nih.gov/32215450/

WHO Consolidated Guidelines on Tuberculosis: Module 5: Management of Tuberculosis in Children and Adolescents https://www.who.int/publications/i/item/9789240046764

Trial of a Six-Month Regimen of High-Dose Rifampicin, High-Dose Isoniazid, Linezolid, and Pyrazinamide Versus a Standard Nine-Month Regimen for the Treatment of Adults and Adolescents With Tuberculous Meningitis https://clinicaltrials.gov/ct2/show/NCT05383742

Randomized Clinical Trial of High-Dose Rifampicin With or Without Levofloxacin Versus Standard of Care for Pediatric Tuberculous Meningitis: The TBM-KIDS Trial https://pubmed.ncbi.nlm.nih.gov/35291004/

Dose-Escalation Study of Isoniazid in Healthy Volunteers With the Rapid Acetylator Genotype of Arylamine N-Acetyltransferase 2 https://pubmed.ncbi.nlm.nih.gov/17665185/

Role of Aspirin in Tuberculous Meningitis: A Systematic Review and Meta-analysis https://pubmed.ncbi.nlm.nih.gov/31512620/

Tumor Necrosis Factor Antagonists for Paradoxical Inflammatory Reactions in the Central Nervous System Tuberculosis: Case Report and Review https://pubmed.ncbi.nlm.nih.gov/33120751/

Pretomanid in the Treatment of Patients With Tuberculosis in the United States https://pubmed.ncbi.nlm.nih.gov/36053513/

Dynamic 18F-Pretomanid PET Imaging in Animal Models of TB Meningitis and Human Studies https://pubmed.ncbi.nlm.nih.gov/36581633/

A Phase 2 Trial to Evaluate the EBA, Safety and Tolerability of Eto Alone and in Combination With BVL-GSK098 (BETO) https://clinicaltrials.gov/ct2/show/NCT05473195