Haruka Okamoto & Kehan Bao on hepatic PKA mediating liver and pancreatic α-cell cross talk, Greg Kowalski on the effect of small blood glucose increases on endogenous glucose production, and “Sweet Talk” with the 2025 Outstanding Scientific Achievement Award recipient Shingo Kajimura.

Welcome to the June 2025 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the June 2025 issue of Diabetes.

4:40 In the first interview segment, our hosts discuss June’s Paper of the Month, titled “Hepatic PKA Mediates Liver and Pancreatic α-Cell Cross Talk.” They’re joined by corresponding author Dr. Haruka Okamoto, Director of Obesity Research at Regeneron Pharmaceuticals, and lead author Dr. Kehan Bao, a postdoctoral fellow at Regeneron. This article is available for free at doi.org/10.2337/db24-0958.

17:25 Our hosts speak with Greg M. Kowalski, PhD, Associate Professor with both the School of Medicine and the Institute for Physical Activity and Nutrition at the Deakin University’s Faculty of Health in Victoria, Australia. He is the corresponding author of a featured article in the June issue, “The Effect of Small Increases in Blood Glucose on Insulin Secretion and Endogenous Glucose Production in Humans,” available for free at doi.org/10.2337/db24-0388.

33:55 In this month’s edition of “Sweet Talk,” our hosts are joined by Shingo Kajimura, PhD, professor at Beth Israel Deaconess Medical Center in Boston and the recipient of the ADA’s 2025 Outstanding Scientific Achievement Award. They discuss his work with brown and beige fat control and their effects on energy balance and metabolic health.

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

Welcome to the May 2025 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the May 2025 issue of Diabetes.

6:25 In the first interview segment, our hosts discuss May’s Paper of the Month, titled “β-Cell Secretory Capacity Predicts Metabolic Outcomes Over 6 Years After Human Islet Transplantation.” They’re joined by corresponding author Michael R. Rickels, MD, MS, Willard Rhoda Ware Professor in Diabetes and Metabolic Diseases in the Division of Endocrinology, Diabetes, and Metabolism Department of Medicine at the University of Pennsylvania Perelman School of Medicine, and and co-host of the podcast Diabetes Care On Air. This article is available for free at doi.org/10.2337/db24-0729

25:30 It’s a special two-part edition of “Sweet Talk.” In part one, our hosts focus on the upcoming 85th Scientific Sessions of the American Diabetes Association. They’re joined by Mark A. Atkinson, American Diabetes Association Eminent Scholar for Diabetes Research and the Jeffrey Keene Family Professor at The University of Florida, and chair of this year’s Scientific Sessions programming committee.

48:10 In part two, our hosts speak with Steven Kahn, MB, ChB, Professor of Medicine at the University of Washington (UW) and Director of the UW Diabetes Research Center. Dr. Kahn is the 2025 recipient of the American Diabetes Association’s Banting Medal for Scientific Achievement, and he discusses his landmark paper, “Quantification of the Relationship Between Insulin Sensitivity and β-Cell Function in Human Subjects: Evidence for a Hyperbolic Function,” available for free at doi.org/10.2337/diab.42.11.1663.

They also discuss the legacy of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) in honor of its 75th anniversary. A special compendium of NIDDK studies is available at diabetesjournals.org/collection/2745/NIDDK-75th-Anniversary-Collection.

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

Welcome to the April 2025 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the April 2025 issue of Diabetes.

6:30 In the first interview segment, our hosts discuss an article titled “Cisplatin Exposure Dysregulates Insulin Secretion in Male and Female Mice.” They’re joined by corresponding author Jennifer E. Bruin, BSc, PhD, an associate professor in the Department of Biology and Institute of Biochemistry at Carleton University in Ottawa, Canada, and lead author Lahari Basu, PhD candidate at Carleton University. This article is available for free at doi.org/10.2337/db24-0419.

25:20 Our hosts discuss the latest Paper of the Month, entitled “An Alternatively Translated Isoform of PPARG Suggests AF-1 Domain Inhibition as an Insulin Sensitization Target.” They’re joined by corresponding author Amit R. Majithia, MD, Associate Professor in the Division of Endocrinology in the Department of Medicine at the UC San Diego School of Medicine. This article is available for free at doi.org/10.2337/db24-0497.

38:55 In the special edition of “Sweet Talk,” our hosts reflect on the life and legacy of David Wasserman, PhD, a pioneer in metabolic research with a lasting impact in exercise physiology, glucose metabolism, and diabetes. They’re joined by the people who knew him best: Maren Laughlin, PhD, Senior Advisor for Integrative Physiology at the National Institutes of Health, Julio Ayala, PhD, Director of the Vanderbilt Mouse Metabolic Phenotyping Center, and Shawn Burgess, PhD, professor at UT Southwestern Medical Center in Dallas, Texas.

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!