An estimand is a description of the research question a trial seeks to answer, which can help researchers better understand how their study should be designed and analysed. Estimands also provide a clear way to communicate treatment effects to different stakeholders. This episode of the Trial Talk podcast features Principal Research Fellow Brennan Kahan, exploring how triallists could benefit from using estimands. Brennan also discusses his recent paper which aims to demystify new guidance on the use of estimands.

Resources:
• The estimands framework: a primer on the ICH E9(R1): www.bmj.com/content/384/bmj-2023-076316
• 'We must let the research question drive study methods' opinion piece: www.ncbi.nlm.nih.gov/pmc/articles/PMC9908044/
• Estimands in cluster-randomized trials: choosing analyses that answer the right question: www.ncbi.nlm.nih.gov/pmc/articles/PMC9908044/

For more information and to access the transcript: bit.ly/4dazsWF

For questions or feedback on the podcast series, message us at mrcctu.engage@ucl.ac.uk

As a listener, your opinion is very valuable to us. Please help us to improve the podcast in the future by filling in this short survey: forms.office.com/e/PjfjQ5Mn6g

Date of episode recording: 2024-04-25T00:00:00Z
Duration: 00:21:29
Language of episode: English
Presenter: Charlotte Hartley
Guests: Brennan Kahan
Producer: Charlotte Hartley