The intricate relationship between obstructive sleep apnea syndrome (OSA), gut health, and their associated health consequences has been the subject of numerous scientific studies. The three selected papers delve into this relationship, exploring the role of obesity, gut microbiota, and cognitive dysfunction in O.S.A. By comparing and contrasting these studies, we aim to provide a cohesive understanding of the pathogenesis and potential interventions for this disorder.

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References:

1. Kuvat N, Tanriverdi H, Armutcu F. The relationship between obstructive sleep apnea syndrome and obesity: A new perspective on the pathogenesis in terms of organ crosstalk. The clinical respiratory journal. 2020 Jul;14(7):595-604.

Link: https://onlinelibrary.wiley.com/doi/10.1111/crj.13175

2. Durgan DJ. Obstructive sleep apnea-induced hypertension: role of the gut microbiota. Current hypertension reports. 2017 Apr;19(4):35.

Link: https://link.springer.com/article/10.1007/s11906-017-0732-3

3. Deyang T, Baig AI, Dolkar P, Hediyal TA, Rathipriya AG, Bhaskaran M, PandiPerumal SR, Monaghan TM, Mahalakshmi AM, Chidambaram SB. Sleep apnoea, gut dysbiosis and cognitive dysfunction. The FEBS Journal. 2023 Sep 4.

Link: https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.16960

In this episode: Suicidal behaviors and thoughts, along with their tragic consequences, have been the subject of scientific investigation across the globe. Genetics is a burgeoning field of research in this context, with studies increasingly probing the intricate relationships between genetic markers, epigenetic factors, and predispositions towards self-harm and suicidal tendencies. The following is a comparative review of three paramount studies in this area.

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References:

1- Li QS, Shabalin AA, DiBlasi E, Gopal S, Canuso CM, FinnGen, International Suicide Genetics Consortium, Palotie A, Drevets WC, Docherty AR, Coon H. Genome-wide association study meta-analysis of suicide death and suicidal behavior. Molecular psychiatry. 2023 Feb;28(2):891-900.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908547/

2- Erlangsen A, Appadurai V, Wang Y, Turecki G, Mors O, Werge T, Mortensen PB, Starnawska A, Børglum AD, Schork A, Nudel R. Genetics of suicide attempts in individuals with and without mental disorders: a population-based genome-wide association study. Molecular Psychiatry. 2020 Oct;25(10):2410-21.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515833/

3- Mirza S, Docherty AR, Bakian A, Coon H, Soares JC, Walss‐Bass C, Fries GR. Genetics and epigenetics of self‐injurious thoughts and behaviors: Systematic review of the suicide literature and methodological considerations. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2022 Oct;189(7-8):221-46.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900606/

In this episode: Three papers delve into the potential link between labor epidural analgesia (LEA) and postpartum depression (PPD). These studies, each employing different methodologies and sample sizes, aim to provide insights into whether the use of L.E.A during labor influences the onset or prevalence of P.P.D.

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References:

1. Almeida M, Kosman KA, Kendall MC, De Oliveira GS. The association between labor epidural analgesia and postpartum depression: a systematic review and meta-analysis. BMC women's health. 2020 Dec;20(1):1-7.

Link: https://bmcwomenshealth.biomedcentral.com/articles/10.1186/s12905-020-00948-0

2. Edipoglu IS, Aslan DD. Association of postpartum depression and epidural analgesia in women during labor: an observational study. Brazilian Journal of Anesthesiology. 2021 Jun 30;71:208-13.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373269/

3. Kountanis JA, Vahabzadeh C, Bauer S, Muzik M, Cassidy R, Aman C, MacEachern M, Bauer ME. Labor epidural analgesia and the risk of postpartum depression: a meta-analysis of observational studies. Journal of clinical anesthesia. 2020 May 1;61:109658.