A central question in platelet transfusion is whether to follow a restrictive or liberal strategy in decisions about which patients should receive platelets. Author Ryan Metcalf, MD, University of Utah, discusses new clinical guidelines for platelet transfusion and more with JAMA Executive Editor Gregory Curfman, MD.

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• Trends in Red Blood Cell, Plasma, and Platelet Transfusions in the United States, 1993-2014

Immune thrombotic thrombocytopenic purpura (iTTP) is a rare coagulopathic disorder characterized by immune-mediated thrombocytopenia and microangiopathic hemolytic anemia, that can cause life-threatening thrombosis. Coauthor Allyson M. Pishko, MD, MSCE, of the University of Pennsylvania joins JAMA Associate Editor David Simel, MD, MHS, to discuss the recent review of iTTP published in JAMA.

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• Immune Thrombotic Thrombocytopenic Purpura

The human microbiome appears to influence risk for development and progression of cancer and response to treatment. Author Jennifer Wargo, MD, University of Texas M.D. Anderson Cancer Center, discusses basic science and clinical evidence regarding the human microbiome and cancer risk with JAMA Deputy Editor Mary McGrae McDermott, MD.

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• The Microbiome and Cancer