According to the World Health Organization (WHO), social determinants of health (SDOH) are defined as the circumstances in which humans are born, develop, live, earn, and age. They are non-medical factors that influence health outcomes. The
distribution of money, power, and resources shapes these circumstances1. These socioeconomic variables contribute to societal stratification and health disparities among persons of different social and economic classes, genders, and ethnicity.

In this episode our MSL co-hosts Shweta Kulkarni, PhD and Mary Voelmle NP, CDCES have a conversation with Shideh Majidi, MD on how the landscape and incidence of T1D diagnosis and treatment is changing. Dr. Majidi identifies key barriers and attitudes that physicians and other healthcare providers may encounter when discussing screening for type 1 diabetes, particularly among patients from under resourced communities with unique challenges that are encountered daily. We conclude the episode with concrete actions and resources our listeners can use to begin to narrow the gap on healthcare disparities within under resourced communities when approaching patients and their families on education on the incidence of T1D and the option to potentially screen for T1D.

Supporting literature from episode:
1. Felicia Hill-Briggs et al. Social Determinants of Health and Diabetes: A Scientific Review. Diabetes Care 1 January 2021; 44 (1): 258–279. https://doi.org/10.2337/dci20-0053.
2. Chelak K, Chakole S. The Role of Social Determinants of Health in Promoting Health Equality: A Narrative Review. Cureus. 2023 Jan 5;15(1):e33425. doi:10.7759/cureus.33425. PMID:36751221; PMCID: PMC9899154.
3. T1D Exchange Quality Improvement Collaborative; Driving Equity and Innovation in the T1D Exchange Quality Improvement Collaborative: Advancing Outcomes Through Collaborative Change. https://doi.org/10.2337/cd23-0070.
4. Alkhatib EH, Majidi S. et al. Feasibility of caregiver diabetes distress screening in routine clinical care of youth with type 1 diabetes. Diabet Med. 2024; 00:e15416. doi:10.1111/dme.15416.
5. Divers J, et al. MMWR Morb Mortal Wkly Rep. 2020; 69(6):161-165.
6. Majidi S, et al. T1D Exchange Quality Improvement Collaborative Study Group. Inequities in Health Outcomes in Children and Adults With Type 1 Diabetes: Data From the T1D Exchange Quality Improvement Collaborative. Clin Diabetes. 2021 Jul;39(3):278-283. doi: 10.2337/cd21-0028. PMID: 34421203; PMCID: PMC8329009.
7. Moshe Phillip, Linda A. DiMeglio et al.; Consensus Guidance for Monitoring Individuals With Islet Autoantibody–Positive Pre-Stage 3 Type 1 Diabetes. Diabetes Care 25 July 2024; 47 (8): 1276–1298. https://doi.org/10.2337/dci24-0042.

Music: Spark of Inspiration by Shane Ivers - https://www.silvermansound.com

This program is non-promotional and sponsored by Sanofi. Presenter(s) were compensated and/or received an honorarium from Sanofi in connection with this program. This program does not constitute an endorsement by Sanofi of any particular organization or its programming. Additional resources and information may be available and should be investigated.

This podcast is intended for US residents only. Sanofi does not provide medical advice, diagnosis, or treatment. The health information contained herein is provided for general educational purposes only. Your healthcare professional is the best source of information regarding your health. Please consult your healthcare professional if you have any questions about your health or treatment.

In this episode, we will feature a compelling discussion with Dr. Teresa Quattrin, MD on addressing the challenges posed by social determinants of health in the screening process for Type 1 Diabetes (T1D). Our MSL co-hosts, Anil Jacob, PharmD, and Mary Voelmle, NP, CDCES, engage Dr. Quattrin in an insightful conversation about breaking down barriers and overcoming challenges faced by under-resourced communities. Dr. Quattrin sheds light on key obstacles and attitudes healthcare providers may encounter, especially when discussing T1D screening among racial and ethnic minority populations. We conclude by providing actionable strategies and resources that our listeners can utilize to narrow the healthcare disparity gap. This includes practical guidance on how to approach patients and their families regarding education on T1D screening.

Supporting literature from episode:
1. Felicia Hill-Briggs, et al. Social Determinants of Health and Diabetes: A Scientific Review. Diabetes Care 1 January 2021;44 (1):258–279. https://doi.org/10.2337/dci20-0053.

2. Chelak K, Chakole S. The Role of Social Determinants of Health in Promoting Health Equality: A Narrative Review. Cureus. 2023 Jan 5;15(1):e33425. doi: 10.7759/cureus.33425. PMID: 36751221. PMCID: PMC9899154.

3. A H Mokdad, et al. Diabetes trends in the U.S.: 1990-1998. Diabetes Care. 1 September 2000; 23(9):1278–1283. https://doi.org/10.2337/diacare.23.9.1278.

4. Denys T. Lau, et al. 2023:Data Related to Social Determinants of Health Captured in the National Health and Nutrition Examination Survey. American Journal of Public Health. 113;1290-1295. https://doi.org/10.2105/AJPH.2023.307490.

5. Moshe Phillip, et al. Consensus Guidance for Monitoring Individuals With Islet Autoantibody–Positive Pre-Stage 3 Type 1 Diabetes. Diabetes Care. 25 July 2024; 47(8):1276–1298. https://doi.org/10.2337/dci24-0042.

6. Sofia Learns About Research: https://www.research.buffalo.edu/sofia/

Music: Spark of Inspiration by Shane Ivers - https://www.silvermansound.com

MAT-US-2500094(v1.0)-P
Approved Distribution
Exp: 11/6/2026

This program is non-promotional and sponsored by Sanofi. Presenter(s) were compensated and/or received an honorarium from Sanofi in connection with this program. This program does not constitute an endorsement by Sanofi of any particular organization or its programming. Additional resources and information may be available and should be investigated.

This podcast is intended for US residents only. Sanofi does not provide medical advice, diagnosis, or treatment. The health information contained herein is provided for general educational purposes only. Your healthcare professional is the best source of information regarding your health. Please consult your healthcare professional if you have any questions about your health or treatment.

In this episode our hosts Katie McMurry, PharmD (US Transplant MSL) and Amber Lawson, PharmD (US Transplant MSL) have a conversation with Dr. Michael Verneris, MD. Dr. Verneris is a Professor of Pediatrics and the Barton Family Endowed Chair of Bone Marrow Transplant at the University of Colorado Denver School of Medicine. He also serves as the Director of Bone Marrow Transplantation and Cellular Therapy at the Children’s Hospital Colorado. In addition, he is currently serving as Vice Chair of the Pediatric Blood and Marrow Transplant Consortium (PBMTC). Dr. Verneris will take us through some of the impacts socioeconomic status has on hematopoietic cell transplant outcomes in the pediatric population as well as some of the data gaps that need to be addressed going forward in this patient population.

Supporting Literature and References:

1. “Neighborhood poverty and pediatric allogeneic hematopoietic cell transplantation outcomes: a CIBMTR analysis”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845011/
2. “Prevalence and Impact of Financial Hardship among New England Pediatric Stem Cell Transplantation Families” https://pubmed.ncbi.nlm.nih.gov/25445021/
3. “Social determinants of health predict health outcomes following pediatric allogeneic hematopoietic stem cell transplant” https://pubmed.ncbi.nlm.nih.gov/38302730/
4. “Social regulation of human gene expression: mechanisms and implications for public health” https://pubmed.ncbi.nlm.nih.gov/23927506/
5. “The conserved transcriptional response to adversity” https://pubmed.ncbi.nlm.nih.gov/31592179/
6. “Alterations in leukocyte transcriptional control pathway activity associated with major depressive disorder and antidepressant treatment” https://pubmed.ncbi.nlm.nih.gov/27219347/
7. “Low socioeconomic status, adverse gene expression profiles, and clinical outcomes in hematopoietic stem cell transplant recipients” https://pubmed.ncbi.nlm.nih.gov/26286914/
8. “Molecular correlates of socioeconomic status and clinical outcomes following hematopoietic cell transplantation for leukemia” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859844/
9. “The health risk of social disadvantage is transplantable into a new host” https://pubmed.ncbi.nlm.nih.gov/39008669/
10. “Mindfulness-Based Stress Reduction training reduces loneliness and pro-inflammatory gene expression in older adults: A small randomized controlled trial” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635809/
11. “Yogic meditation reverses NF-kappa B and IRF-related transcri

This program is non-promotional and sponsored by Sanofi. Presenter(s) were compensated and/or received an honorarium from Sanofi in connection with this program. This program does not constitute an endorsement by Sanofi of any particular organization or its programming. Additional resources and information may be available and should be investigated.

This podcast is intended for US residents only. Sanofi does not provide medical advice, diagnosis, or treatment. The health information contained herein is provided for general educational purposes only. Your healthcare professional is the best source of information regarding your health. Please consult your healthcare professional if you have any questions about your health or treatment.