In this illuminating episode of the Longevity India podcast, we're joined by esteemed scientist, Dr. Suresh Rattan, to delve deep into the world of hormesis and its significance in ageing and wellbeing. Key Discussion Points: Understanding Hormesis & Hormetins: Discover the nonlinear biphasic relationship of stress response and how it plays a crucial role in healthy ageing. Challenging Yourself: Learn about achieving and enjoying healthy ageing through hormesis and the positive effects of choosing a mild stress repeatedly. Hormetins and Their Role: Uncover the potential of natural and synthetic compounds, known as hormetins, which can produce hormetic effects by activating stress response pathways. From physical and nutritional to mental hormetins, explore how various practices and substances can fortify our homeodynamic space. About Dr. Suresh Rattan: Dr. Suresh Rattan, an acclaimed academic, earned his D.Sc. from Aarhus University, Denmark in 1995, and Ph.D. from the National Institute for Medical Research, London, UK in 1982. He pursued his M.Phil. from Jawaharlal Nehru University, New Delhi, India in 1979. Under the mentorship of eminent personalities like Robin Holliday, Ian Buchanan, and Sivatosh Mookerjee, he has gained profound expertise in the realm of ageing and homeodynamics. Join us in this episode as we explore the fine line between beneficial and harmful stress, and how understanding this balance can lead us to healthier and longer lives.

In this episode, we are thrilled to host Dr. Pankaj Kapahi, a renowned expert in the realm of aging and gerontology. With a prolific academic journey that began at the University of Manchester under the guidance of Tom Kirkwood, and later took him to work alongside esteemed researchers like Seymour Benzer at Caltech and Michael Karin at the University of California, San Diego, Dr. Kapahi's career has been marked by pioneering research and profound discoveries. Currently associated with the Buck Institute since 2004, Dr. Kapahi's accolades include over 80 scientific papers, three patents, and a slew of awards that bear testament to his dedication and expertise in the field. Among his honors are the Eureka Award from the National Institute on Aging, the New Scholar Award from the Ellison Medical Foundation, the Glenn Award for Research in Biological Mechanisms of Aging, and several others. Apart from his research, Dr. Kapahi is also lauded for introducing the first master’s degree course in gerontology at the Buck Institute and his contributions to esteemed journals like Aging Cell, Aging, and PLOS Genetics. In this podcast episode, Dr. Kapahi delves deep into: The impact and benefits of Dietary Restriction (DR) as a method to extend lifespan and counteract age-related diseases. The parallels between the lifespan-extending effects of inhibiting the TOR pathway and the effects of DR in organisms like D. melanogaster, S. cerevisiae, and C. elegans. The ongoing efforts in the Kapahi lab to comprehend how organisms gauge nutrient status to influence their health and vulnerability to diseases. An insightful exploration of advanced glycation end products - their formation, their detrimental effects on our health, the variety found within the body, and the foods that are rich in these compounds. Fascinating results from experiments on model organisms when the detoxification process of advanced glycation end products was expedited. Join us for a captivating journey into the intricate mechanisms of aging and the potential interventions that promise a longer, healthier life. Don't forget to like, share, and subscribe for more enlightening conversations on the Longevity India Podcast!

In this insightful episode, we are privileged to host Dr. Suresh Ratan, a biogerontologist and an eminent senior scientist at Aarhus University, Denmark. Join us as we journey through the fascinating world of gerontology, understanding its roots, present scenarios, and exciting prospects for the future. 🎙️ Episode Highlights: Hayflick's Paradigm: Dive into the foundational observations that led to the understanding that cells have a finite lifespan, shedding light on the cellular mechanisms behind aging. The Myth of Aging Genes: Dr. Ratan debunks common misconceptions about genes causing aging. Instead, he introduces us to 'gerento genes' - his novel concept suggesting genes that defend us against aging. But like all natural processes, they aren't flawless. The Game of Lifespan: Learn about the intriguing difference between 'essential lifespan' - the period needed for successful reproduction, and 'maximal lifespan' - the ultimate boundary of an organism's life. Did you know humans have an essential lifespan of around 45 years? When Do We Start Aging?: A riveting discussion on the onset of the aging process in humans. Prepare to be surprised! The Enigma of Senescent Cells: Discover the journey of how senescent cells were identified and their role in aging. Plus, get Dr. Ratan's expert take on the emerging field of senolytics. Gut Microbiome & Aging: A brief exploration on how our gut health might be intertwined with the aging process, spotlighting cutting-edge research in this area. Disclaimer: In the episode, there was a mention of there being ten-thousand species of bacteria in our microbiome. To clarify, scientists typically estimate a range of about 300 to one-thousand different species (the exact number is still under research), with the total bacterial count being somewhere around 5 to 10-trillion. Don't forget to Like, Share, and Subscribe for more deep dives into the world of longevity and aging research! Drop your questions and comments below, and we'll ensure to bring more experts like Dr. Ratan to answer them.