Drs Nihar Desai, Andrew J. Sauer, and Matthew A. Sparks discuss novel therapies in cardiorenal metabolic syndrome, focusing in on the MRAs and potassium binders.

Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/999843. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

The Kidney Failure Risk Equation: Evaluation of Novel Input Variables Including eGFR Estimated Using the CKD-EPI 2021 Equation in 59 Cohorts https://pubmed.ncbi.nlm.nih.gov/36857500/

Cardiovascular-Kidney-Metabolic Health: A Presidential Advisory From the American Heart Association https://pubmed.ncbi.nlm.nih.gov/37807924/

KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease https://pubmed.ncbi.nlm.nih.gov/38490803/

Heart Failure in Patients With Chronic Kidney Disease https://pubmed.ncbi.nlm.nih.gov/37763045/

Lokelma Prescribing Information https://den8dhaj6zs0e.cloudfront.net/50fd68b9-106b-4550-b5d0-12b045f8b184/6de8f71b-d3af-4f76-9600-907c98616be6/6de8f71b-d3af-4f76-9600-907c98616be6_viewable_rendition__v.pdf

Sodium Zirconium Cyclosilicate in Hyperkalemia https://pubmed.ncbi.nlm.nih.gov/25415807/

Veltassa Prescribing Information https://veltassa.com/pi

Patiromer for the Management of Hyperkalemia in Heart Failure With Reduced Ejection Fraction: The DIAMOND Trial https://pubmed.ncbi.nlm.nih.gov/35900838/

Sodium Zirconium Cyclosilicate in HFrEF and Hyperkalemia: REALIZE-K Design and Baseline Characteristics https://pubmed.ncbi.nlm.nih.gov/38878009/

Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes https://pubmed.ncbi.nlm.nih.gov/33264825/

Finerenone Reduces Risk of Incident Heart Failure in Patients With Chronic Kidney Disease and Type 2 Diabetes: Analyses From the FIGARO-DKD Trial https://pubmed.ncbi.nlm.nih.gov/34775784/

Press Release: First Patient Enrolled in CARE-HK in HF to Evaluate Role of Veltassa® (Patiromer) in Enabling RAASi Treatment https://newsroom.csl.com/2021-04-28-First-patient-enrolled-in-CARE-HK-in-HF-to-evaluate-role-of-Veltassa-R-patiromer-in-enabling-RAASi-treatment

Medical Therapy for Heart Failure With Reduced Ejection Fraction: The CHAMP-HF Registry https://pubmed.ncbi.nlm.nih.gov/30025570/

Finerenone in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction: Rationale and Design of the FINEARTS-HF Trial https://pubmed.ncbi.nlm.nih.gov/38742248/

Additional Studies With Finerenone Across a Wide Range of Heart Failure Patients Initiated https://www.bayer.com/media/en-us/additional-studies-with-finerenone-across-a-wide-range-of-heart-failure-patients-initiated/

Treatment Effects of Empagliflozin in Hospitalized Heart Failure Patients Across the Range of Left Ventricular Ejection Fraction — Results From the EMPULSE Trial https://pubmed.ncbi.nlm.nih.gov/38572654/

Safety, Tolerability and Efficacy of Up-Titration of Guideline-Directed Medical Therapies for Acute Heart Failure (STRONG-HF): A Multinational, Open-Label, Randomised, Trial https://pubmed.ncbi.nlm.nih.gov/36356631/

Steroidal MRA Across the Spectrum of Renal Function: A Pooled Analysis of RCTs https://pubmed.ncbi.nlm.nih.gov/36328653/

Join Drs Nihar Desai and Matthew Cavender as they discuss the history, studies, and implementation of GLP-1 receptor agonists for people with cardiorenal metabolic syndrome.

Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/999842. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Glucagon-Like Peptide-1 Receptor Agonists https://www.ncbi.nlm.nih.gov/books/NBK551568/#:~:text=Glucagon%2Dlike%20peptide%2D1%20(,options%20for%20these%20endocrine%20diseases.

Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death From Cardiovascular Causes https://pubmed.ncbi.nlm.nih.gov/17517853/

Guidance for Industry on Diabetes Mellitus-Evaluating Cardiovascular Risk in New Antidiabetic Therapies to Treat Type 2 Diabetes; Availability https://www.federalregister.gov/documents/2008/12/19/E8-30086/guidance-for-industry-on-diabetes-mellitus-evaluating-cardiovascular-risk-in-new-antidiabetic

Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes https://pubmed.ncbi.nlm.nih.gov/27295427/

Effects of Oral Semaglutide on Cardiovascular Outcomes in Individuals With Type 2 Diabetes and Established Atherosclerotic Cardiovascular Disease and/or Chronic Kidney Disease: Design and Baseline Characteristics of SOUL, a Randomized Trial https://pubmed.ncbi.nlm.nih.gov/36945734/

Semaglutide and Cardiovascular Outcomes in Obesity Without Diabetes https://pubmed.ncbi.nlm.nih.gov/37952131/

Heart Failure With Preserved Ejection Fraction (HFpEF) https://www.ncbi.nlm.nih.gov/books/NBK599960/

Effects of Liraglutide on Clinical Stability Among Patients With Advanced Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial https://pubmed.ncbi.nlm.nih.gov/27483064/

Semaglutide Versus Placebo in People With Obesity-Related Heart Failure With Preserved Ejection Fraction: A Pooled Analysis of the STEP-HFpEF and STEP-HFpEF DM Randomised Trials https://pubmed.ncbi.nlm.nih.gov/38599221/

Interpreting the Kansas City Cardiomyopathy Questionnaire in Clinical Trials and Clinical Care: JACC State-of-the-Art Review https://pubmed.ncbi.nlm.nih.gov/33183512/

Comparison of Tirzepatide and Dulaglutide on Major Adverse Cardiovascular Events in Participants With Type 2 Diabetes and Atherosclerotic Cardiovascular Disease: SURPASS-CVOT Design and Baseline Characteristics https://pubmed.ncbi.nlm.nih.gov/37758044/

Coordinated Care to Optimize Cardiovascular Preventive Therapies in Type 2 Diabetes: A Randomized Clinical Trial https://pubmed.ncbi.nlm.nih.gov/36877177/

Join Drs Nihar Desai and Jay Udell as they discuss the role of SGLT2 inhibitors in the treatment of cardiorenal metabolic syndrome.

Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/999841. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Effects of SGLT2 Inhibitors on Kidney and Cardiovascular Function https://pubmed.ncbi.nlm.nih.gov/33197224/

Study to Evaluate the Effect of Empagliflozin on Hospitalization for Heart Failure and Mortality in Patients With Acute Myocardial Infarction - EMPACT-MI https://www.acc.org/Latest-in-Cardiology/Clinical-Trials/2024/04/05/03/00/empact-mi

The Bark Giving Diabetes Therapy Some Bite: The SGLT Inhibitors https://pubmed.ncbi.nlm.nih.gov/30132029/

Effects of Dapagliflozin on Development and Progression of Kidney Disease in Patients With Type 2 Diabetes: An Analysis From the DECLARE-TIMI 58 Randomized Trial https://pubmed.ncbi.nlm.nih.gov/31196815/

Thiazolidinediones and Heart Failure: A Teleo-Analysis https://pubmed.ncbi.nlm.nih.gov/17536074/

Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes https://pubmed.ncbi.nlm.nih.gov/26378978/

Sotagliflozin in Patients With Diabetes and Recent Worsening Heart Failure https://pubmed.ncbi.nlm.nih.gov/33200892/

Effect of Empagliflozin on Heart Failure Outcomes After Acute Myocardial Infarction: Insights From the EMPACT-MI Trial https://pubmed.ncbi.nlm.nih.gov/38581389/

Effects of an Angiotensin-Converting-Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients https://pubmed.ncbi.nlm.nih.gov/10639539/