Drs Sparks and Neuen discuss the proper use of SGLT2 inhibitors to prevent chronic kidney disease, including how to start them and monitor them and their possible side effects.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/971884). The topics and discussions are planned, produced, and reviewed independently of advertiser. This podcast is intended only for US healthcare professionals.

Resources

SGLT2 Inhibitors in Primary Care: 'All Hands on Deck' for Improving Heart Failure Outcomes https://www.medscape.com/viewarticle/965473

Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes https://www.nejm.org/doi/full/10.1056/nejmoa1611925

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy https://www.nejm.org/doi/full/10.1056/nejmoa1811744

CKD Epidemiology Collaboration CKD-EPI Consortium https://www.tuftsmedicalcenter.org/research-clinical-trials/institutes-centers-labs/chronic-kidney-disease-epidemiology-collaboration/overview

Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes https://www.nejm.org/doi/full/10.1056/NEJMoa2025845

Net Effects of Sodium-Glucose Co-Transporter-2 Inhibition in Different Patient Groups: A Meta-Analysis of Large Placebo-Controlled Randomized Trials https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(21)00443-0/fulltext

EMPA-KIDNEY (The Study of Heart and Kidney Protection With Empagliflozin) https://www.empakidney.org/

FDA Removes Boxed Warning About Risk of Leg and Foot Amputations for the Diabetes Medicine Canagliflozin (Invokana, Invokamet, Invokamet XR) https://www.fda.gov/drugs/fda-drug-safety-podcasts/fda-removes-boxed-warning-about-risk-leg-and-foot-amputations-diabetes-medicine-canagliflozin

What do primary care providers need to know to improve care for people with chronic kidney disease? Drs Matthew Sparks and Ian de Boer provide key clinical takeaways that can't be ignored.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/971885). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

KDIGO 2020 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease https://www.kidney-international.org/article/S0085-2538(20)30718-3/fulltext

KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease https://kdigo.org/wp-content/uploads/2022/03/KDIGO-2022-Diabetes-Management-GL_Public-Review-draft_1Mar2022.pdf

Effects of SGLT2 Inhibitors on EGFR in Type 2 Diabetic Patients—The Role of Antidiabetic and Antihypertensive Medications https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099726/

Drs Sparks and Kumar go behind the scenes and discuss the preparation, surgery, and outcome of the pig-to-human kidney xenotransplantation at The University of Alabama.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/971886). The topics and discussions are planned, produced, and reviewed independently of advertiser. This podcast is intended only for US healthcare professionals.

Resources

The Advancing American Kidney Health Initiative https://www.kidney.org/advocacy/advancing-american-kidney-health-initiative

Nearly 106,000 U.S. Residents Are Waiting for a Lifesaving Transplant https://www.washingtonpost.com/health/2022/05/24/organ-transplant-waiting-list-numbers/

UNOS Patients on the Waiting List vs. Transplants Performed by Organ (2021) https://www.organdonor.gov/learn/organ-donation-statistics/detailed-description#fig1

First Clinical-Grade Porcine Kidney Xenotransplant Using a Human Decedent Model https://onlinelibrary.wiley.com/doi/abs/10.1111/ajt.16930

Mathieu Jaboulay's (1860–1913) Contribution to Xenotransplantation https://onlinelibrary.wiley.com/doi/10.1111/xen.12765

Alexis Carrel - Biographical https://www.nobelprize.org/prizes/medicine/1912/carrel/biographical/

5 Things to Know About CRISPR https://www.medscape.com/viewarticle/899354

Organ Donation and Transplantation Alliance https://www.organdonationalliance.org/

When Pigs Fly https://onlinelibrary.wiley.com/doi/10.1111/ajt.16963

C4d Staining in Renal Allograft Biopsies With Early Acute Rejection and Subsequent Clinical Outcome https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087790/

Results of Two Cases of Pig-to-Human Kidney Xenotransplantation https://www.nejm.org/doi/10.1056/NEJMoa2120238

University of Maryland School of Medicine Faculty Scientists and Clinicians Perform Historic First Successful Transplant of Porcine Heart Into Adult Human With End-stage Heart Disease https://www.medschool.umaryland.edu/news/2022/University-of-Maryland-School-of-Medicine-Faculty-Scientists-and-Clinicians-Perform-Historic-First-Successful-Transplant-of-Porcine-Heart-into-Adult-Human-with-End-Stage-Heart-Disease.html

Thomas E. Starzl Transplantation Institute http://www.stiresearch.health.pitt.edu/about