In this episode, I had the pleasure of sitting down with Nicolas Verhoeven of Physionic. We focus our attention on metabolic health and, specifically, the energy-related, cellular, and nutritional mechanisms of insulin resistance. Nicolas reviews evidence pertaining to the reversal of insulin resistance and dietary clinical trials demonstrating remission of type 2 diabetes. Nicolas also highlights the synergistic effects of physical activity and dietary habits on insulin resistance, expanding our discussion into mitochondrial health. Finally, we explore importance of a nuanced conversation around autophagy and its role in health and disease prevention. Physionic on YouTube: https://www.youtube.com/@Physionic Chapters: 00:00:13 - Nicolas' Background & Inspiration 00:05:34 - Misconceptions about Carbs & Fat Intake 00:08:57 - Mechanisms of Insulin Resistance 00:18:34 - Reversing Insulin Resistance & Diabetes 00:23:08 - Measuring Insulin Resistance 00:24:20 - Continuous Glucose Monitoring (CGM) 00:30:25 - Insulin Resistance & Health 00:37:33 - Mitochondrial Dysfunction 00:49:14 - Mitochondrial Biogenesis 00:56:05 - Improving Mitochondrial Health 01:02:54 - Autophagy 01:07:28 - Closing Remarks Social & Website: Instagram - https://www.instagram.com/sterlingmdphd Twitter - https://twitter.com/sterlingmdphd Facebook - https://www.facebook.com/sterlingmdphd TikTok - https://www.tiktok.com/@sterlingmdphd Newsletter - http://eepurl.com/hQpdqT Subscribe to the Podcast: Apple Podcasts: https://apple.co/3y438C9 Spotify: https://open.spotify.com/show/5TDUK3F2sJXfnG63hSxJhT?si=40bb52e5b53f404c Google Podcasts: https://bit.ly/3Olanei References & Show Notes: http://www.nicksterling.com/ The content of this podcast is not medical advice, is for general information purposes only, and does not constitute the practice of medicine or any other healthcare professional services. No doctor-patient relationship is formed. The content of this podcast is not a substitute for medical evaluation or treatment and does not take precedence over information provided to you by your healthcare provider or official public health sources. Please visit nicksterling.com/terms for full Terms of Use.