Canadian wildfire smoke threatens air quality across Midwest; Trump announces 50% tariffs on steel, aluminum imports; 500,000 immigrants at risk for deportation after Supreme Court ruling; and more on tonight’s broadcast.

Deadly storms impact the Southern U.S.; Elon Musk departs his role in DOGE; Sean ‘Diddy’ Combs’ former personal assistant cross-examined; Lester Holt signs off after 10 years on Nightly News; and more on tonight’s broadcast.

Appeals court reinstates Trump’s tariffs; Judge blocks Trump ban on Harvard’s foreign students; Former assistant to Sean "Diddy" Combs testifies he repeatedly sexually assaulted her; and more on tonight’s broadcast.

Trump defends massive tax-cut and spending bill after Musk’s criticism; Israel: Hamas leader killed during military operation in Gaza; Convicted murderer and ex-police chief remains on the run three days after prison escape; and more on tonight’s broadcast.

Urgent manhunts for escaped prisoners underway in several states; Secretary Kennedy announces the CDC is changing COVID vaccine recommendations; Documents: Trump administration to stop student visa interviews; and more on tonight’s broadcast.

Car collides with pedestrians celebrating in Liverpool; Severe weather threatens 12 million during Memorial Day travel; Trump marks Memorial Day and lashes out at Harvard; and more on tonight’s broadcast.

American charged with plotting to bomb U.S. Embassy office in Israel; 1 hospitalized after fuel tanker crash on Florida highway; Severe weather threatens Memorial Day travel rush; and more on tonight’s broadcast.

Charges accuse suspect of torturing Italian citizen for weeks in N.Y.C. townhouse; Severe weather threatens record holiday travel rush; Escaped inmate recaptured as search for New Orleans inmates ramps up ; and more on tonight’s broadcast.