Scientific knowledge of the gut microbiome has increased exponentially over the last decade. Recently, several studies have suggested that specific strains of bacteria, including Akkermansia muciniphila, are key to supporting the environmental conditions required for other related bacterial strains that facilitate healthy metabolic health. In this video, Colleen Cutcliffe, PhD, co-founder and CEO of Pendulum discusses groundbreaking research around Akkermansia mucinophila, the role of short-chain fatty acids (SCFAs) in stimulating GLP-1 pathways, implications for diabetes management, and how gut bacteria influence inflammation, gut integrity, and overall metabolic health. They also explore how diet, antibiotics, and stress impact the microbiome, potential roles of probiotics in inflammatory bowel disease (IBD), pediatric gut health, and exciting emerging research on the gut-brain axis and neurological conditions like Parkinson's disease. Colleen highlights Pendulum's rigorous scientific approach, including clinical trials and innovative manufacturing practices that ensure product viability and effectiveness.

Promotional code STERLING20 can be applied for 20% off of first membership purchases (https://pendulumlife.com). Please note that Dr. Sterling has no financial affiliation with Pendulum. This code is provided only as a discount to listeners and does not constitute a clinical recommendation or medical advice.

Chapters:

- 00:00 Intro: Gut Microbiome Essentials

- 02:03 Pendulum's Biotech Innovation

- 06:15 GLP-1 & Metabolic Health

- 09:59 Probiotic Industry Insights

- 17:17 Importance of Akkermansia

- 24:17 Clinical Results for Diabetes

- 29:28 Manufacturing Challenges

- 39:13 Diet's Impact on Microbiome

- 43:35 Gut-Brain Connection

- 46:50 Next Steps & Resources

Spotify Channel:

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Social & Website:

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X - https://x.com/sterlingmdphd

Newsletter - http://eepurl.com/hQpdqT

Apple Podcasts: https://apple.co/3y438C9

References & Show Notes:

http://www.nicksterling.com/

This content is not medical advice, is for general information purposes only and does not constitute the practice of medicine or any other healthcare professional services. No doctor-patient relationship is formed. This content is not a substitute for medical evaluation or treatment and does not take precedence over information provided to you by your healthcare provider or official public health sources. Please visit http://nicksterling.com/terms for full Terms of Use.

What are some common side effects of medications like Ozempic and Wegovy? From the front lines of healthcare, we explore adverse effects of these medications based on real-world visits to the emergency department. Learn about common side effects such as nausea, dehydration, and muscle wasting, as well as lesser-known risks like starvation ketosis and mood changes. Chapters 0:00 - Introduction to & GLP-1 RAs 0:48 - Nausea and Vomiting as Side Effects 1:52 - Dehydration Leading to Kidney Injury 3:11 - GLP-1 RAs & Starvation Ketosis 4:16 - Muscle Wasting on GLP-1 RAs 5:08 - Depression and Mood Changes 5:39 - Honorable Mention: Gastroparesis Video on Muscle Wasting & GLP-1 Receptor Agonists: https://youtu.be/Po2gC3zG0C8 Spotify Channel: https://podcasters.spotify.com/pod/show/sterlingmdphd/ Social & Website: Instagram - https://www.instagram.com/sterlingmdphd Newsletter - http://eepurl.com/hQpdqT Apple Podcasts: https://apple.co/3y438C9 References & Show Notes: http://www.nicksterling.com/ This content is not medical advice, is for general information purposes only and does not constitute the practice of medicine or any other healthcare professional services. No doctor-patient relationship is formed. This content is not a substitute for medical evaluation or treatment and does not take precedence over information provided to you by your healthcare provider or official public health sources. Please visit http://nicksterling.com/terms for full Terms of Use.