Drs Michael Wechsler and Mario Castro discuss precision medicine for moderate to severe asthma and the past, present, and future of clinical trials.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/969686). The topics and discussions are planned, produced, and reviewed independently of advertiser. This podcast is intended only for US healthcare professionals.

Resources

Precision Interventions for Severe and/or Exacerbation-Prone Asthma Network (PrecISE) Network https://preciseasthma.org/preciseweb/

Asthma https://emedicine.medscape.com/article/296301-overview

The Many 'Buckets' of Severe Asthma: Moving Toward Personalized Managements https://www.jaci-inpractice.org/article/S2213-2198(17)30379-3/pdf

What is Fractional Exhaled Nitric Oxide (FeNO) in Pulmonary Function Testing?https://www.medscape.com/answers/303239-77907/what-is-fractional-exhaled-nitric-oxide-feno-in-pulmonary-function-testing

Periostin is a Systemic Biomarker of Eosinophilic Airway Inflammation in Asthmatic Patients https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626285/

Asthma Workup Approach Considerations https://emedicine.medscape.com/article/296301-workup

PrecISE: Precision Medicine in Severe Asthma: An Adaptive Platform Trial With Biomarker Ascertainment https://www.jacionline.org/article/S0091-6749(21)00352-3/fulltext

KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma https://www.nejm.org/doi/full/10.1056/NEJMoa1613125

PrecISE (Precision Interventions for Severe and/or Exacerbation-Prone Asthma) Network Study https://clinicaltrials.gov/ct2/show/NCT04129931

Designing Clinical Trials to Address the Needs Of Childhood And Adult Asthma: The National Heart, Lung, and Blood Institute's AsthmaNet https://www.jacionline.org/article/S0091-6749(13)01638-2/pdf

Severe Asthma Research Program http://www.severeasthma.org/

Airways Clinical Research Centers https://www.lung.org/research/airways-clinical-research-centers

Lung Health Cohort Study: Making History https://www.lung.org/research/lung-health-cohort-study