Madhukar Trivedi, MD, and Jonathan Downar, MD, review the evidence on the efficacy of transcranial magnetic stimulation as a treatment for major depressive disorder.

Relevant disclosures can be found with the episode show notes on Medscape.com (https://www.medscape.com/viewarticle/968557). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Transcranial Magnetic Stimulation https://www.medscape.com/answers/286759-14790/what-is-the-role-of-transcranial-magnetic-stimulation-tms-in-the-treatment-of-major-depressive-disorder-clinical-depression

Treatment-Resistant Depression https://www.medscape.com/viewarticle/431515_7

ECT https://emedicine.medscape.com/article/1525957-overview

Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Study https://www.nimh.nih.gov/funding/clinical-research/practical/stard

FDA Clears TMS Device for Resistant Depression https://www.medscape.com/viewarticle/777357

FDA Clears Brain Stimulation Device for OCD https://www.medscape.com/viewarticle/900889

FDA Clears First Brain Stimulation Device to Help Smokers Quit https://www.medscape.com/viewarticle/936234

Neuroanatomy of Decision-making https://www.medscape.com/viewarticle/731957_5

Customized Brain Stimulation: New Hope for Severe Depression https://www.medscape.com/viewarticle/960276

Subcallosal Cingulate Deep Brain Stimulation for Treatment-Resistant Depression: A Multisite, Randomised, Sham-Controlled Trial https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(17)30371-1/fulltext

High-Dose Spaced Theta-Burst TMS as a Rapid-Acting Antidepressant in Highly Refractory Depression https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837258/pdf/awx379.pdf

Stanford Accelerated Intelligent Neuromodulation Therapy for Treatment-Resistant Depression https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2019.19070720

A pilot study of magnetic seizure therapy for treatment-resistant obsessive-compulsive disorder https://onlinelibrary.wiley.com/doi/10.1002/da.23097