Drs John Kane and Anil Malhotra discuss neuroimaging and connectivity between various regions of the brain in patients with schizophrenia and how it impacts the pathophysiology and treatment response.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/969530). The topics and discussions are planned, produced, and reviewed independently of advertiser. This podcast is intended only for US healthcare professionals.

Resources

Schizophrenia https://www.medscape.com/resource/schizophrenia

Diffusion Tensor Imaging Measures of White Matter Compared to Myelin Basic Protein Immunofluorescence in Tissue Cleared Intact Brains https://www.sciencedirect.com/science/article/pii/S235234091630779X?via%3Dihub

Baseline Striatal Functional Connectivity as a Predictor of Response to Antipsychotic Drug Treatment https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845897/

Dissecting Heterogeneity of Treatment Response of First Episode Schizophrenia https://grantome.com/grant/NIH/P50-MH080173-05

The M1/M4 Preferring Muscarinic Agonist Xanomeline Modulates Functional Connectivity and NMDAR Antagonist-Induced Changes in the Mouse Brain https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115158/

Therapeutic Potential of TAAR1 Agonists in Schizophrenia: Evidence From Preclinical Models and Clinical Studies https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704992/

ECT and Other Procedures for Schizophrenia https://www.webmd.com/schizophrenia/electroconvulsive-therapy

Electroconvulsive Therapy Augmentation in Clozapine-Resistant Schizophrenia: A Prospective, Randomized Study https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2014.13060787

Long-Acting Antipsychotic Therapies for Patients With Schizophrenia https://reference.medscape.com/recap/949130

Psychosis Relapse During Treatment With Long-Acting Injectable Antipsychotics in Individuals With Schizophrenia-Spectrum Disorders: An Individual Participant Data Meta-analysis https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(20)30264-9/fulltext

North American Prodrome Longitudinal Study https://napls.ucsf.edu/

Association Between Residential Instability at Individual and Area Levels and Future Psychosis in Adolescents at Clinical High Risk From the North American Prodrome Longitudinal Study (NAPLS) Consortium https://www.sciencedirect.com/science/article/abs/pii/S0920996421003959?via%3Dihub

Clinical, Brain, and Multilevel Clustering in Early Psychosis and Affective Stages https://jamanetwork.com/journals/jamapsychiatry/article-abstract/2792519

Brain Disease and Psychiatric Illness: When Should a Psychiatrist Order a CAT Scan? https://ajp.psychiatryonline.org/doi/10.1176/ajp.141.12.1521

Transcranial Magnetic Stimulation for Positive Symptoms in Schizophrenia: A Systematic Review https://www.karger.com/Article/FullText/502148