Drs Wechsler, Bacharier, and Phipatanakul discuss moderate to severe childhood asthma.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/969691). The topics and discussions are planned, produced, and reviewed independently of advertiser. This podcast is intended only for US healthcare professionals.

Resources:

Precision Interventions for Severe and/or Exacerbation-Prone Asthma (PrecISE) Network https://preciseasthma.org/preciseweb/

Inhaled Corticosteroid Therapy in Children: An Assessment of the Potential for Side Effects https://www.ncbi.nlm.nih.gov/pmc/articles/PMC475319/pdf/thorax00304-0005.pdf

Inhaled Corticosteroids in Children: Effects on Bone Mineral Density and Growth https://linkinghub.elsevier.com/retrieve/pii/S2213-2600(14)70024-4

Aerochamber https://aerochamber.com/

Pulmonary Function Testing https://emedicine.medscape.com/article/303239-overview

Using Impulse Oscillometry in Clinical Practice https://www.medscape.com/viewarticle/862265

Global Initiative for Asthma Guidelines https://ginasthma.org/

National Asthma Education Prevention Program Guidelines https://www.nhlbi.nih.gov/health-topics/asthma-management-guidelines-2020-updates

Omalizumab Prescribing Information https://www.gene.com/download/pdf/xolair_prescribing.pdf

Mepolizumab Prescribing Information https://gskpro.com/content/dam/global/hcpportal/en_US/Prescribing_Information/Nucala/pdf/NUCALA-PI-PIL-IFU-COMBINED.PDF

Benralizumab Prescribing Information https://den8dhaj6zs0e.cloudfront.net/50fd68b9-106b-4550-b5d0-12b045f8b184/3647bed4-ce91-4fe7-9bc5-32dbee73f80a/3647bed4-ce91-4fe7-9bc5-32dbee73f80a_viewable_rendition__v.pdf

Dupilumab in Children With Uncontrolled Moderate-to-Severe Asthma https://www.nejm.org/doi/10.1056/NEJMoa2106567

Dupilumab Prescribing Information https://www.regeneron.com/downloads/dupixent_fpi.pdf

Tezepelumab Prescribing Information https://den8dhaj6zs0e.cloudfront.net/50fd68b9-106b-4550-b5d0-12b045f8b184/e306dc06-d580-4457-b15f-9f28545ad63a/e306dc06-d580-4457-b15f-9f28545ad63a_viewable_rendition__v.pdf

Preventing Asthma in High Risk Kids (PARK) With Omalizumab: Design, Rationale, Methods, Lessons Learned and Adaptation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887056/