Drs Madhukar Trivedi and Gregory Fonzo discuss the state of evidence and models for the use of psychedelic drugs in patients with major depressive disorder.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/968561). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Depression https://emedicine.medscape.com/article/286759-overview

What Is the Role of Transcranial Magnetic Stimulation (TMS) in the Treatment of Major Depressive Disorder (Clinical Depression)? https://www.medscape.com/answers/286759-14790/what-is-the-role-of-transcranial-magnetic-stimulation-tms-in-the-treatment-of-major-depressive-disorder-clinical-depression

New Expert Guidance on Ketamine for Resistant Depression https://www.medscape.com/viewarticle/948097

Trending Clinical Topic: Psychedelics https://reference.medscape.com/viewarticle/971428

The Safety and Efficacy of COMP360 Psilocybin Therapy in Treatment-Resistant Depression: Results from a Phase IIb Randomized Controlled Trial https://j8g9v7z6.rocketcdn.me/wp-content/uploads/2022/05/Compass_APA_Poster_v5.1.pdf

Psilocybin Effective Up to 12 Weeks in Severe Depression https://www.medscape.com/viewarticle/974935

Psychedelic Resting-State Neuroimaging: A Review and Perspective on Balancing Replication and Novel Analyses https://www.sciencedirect.com/science/article/pii/S0149763422001786

LSD Alters Dynamic Integration and Segregation in the Human Brain https://www.sciencedirect.com/science/article/pii/S1053811920311381

Center for Psychedelic Research & Therapy https://dellmed.utexas.edu/units/center-for-psychedelic-research-and-therapy

MDMA-Assisted Therapy for Severe PTSD: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study https://www.nature.com/articles/s41591-021-01336-3

The Emerging Science of Microdosing: A Systematic Review of Research on Low Dose Psychedelics (1955-2021) and Recommendations for the Field https://www.sciencedirect.com/science/article/pii/S0149763422001956

Oregon Psilocybin Services https://www.oregon.gov/oha/PH/PREVENTIONWELLNESS/Pages/Oregon-Psilocybin-Services.aspx