Aspirin, or acetylsalicylic acid, is one of the oldest and most widely used medications in the world.

Well known for its analgesic effects, it was later discovered to be effective (in much smaller doses) in preventing platelet aggregation that had a pivotal role in arterial thrombosis.

Its role in inhibiting platelet activity has made it a cornerstone in the prevention and treatment of arterial thrombosis. In this article, we will explore the fascinating role of platelets in acute coronary thrombosis, the mechanisms by which aspirin exerts its protective effects, and the clinical considerations for its use.

https://www.scvc.co.uk/naked-heart/aspirin/

The timing of intervention in aortic stenosis is critical. Delaying surgery or transcatheter procedures until symptoms become severe or complications arise can lead to poorer outcomes. Conversely, intervening too early may expose patients to unnecessary procedural risks. For exceptionally fit individuals aged 75-85, timely intervention can be particularly advantageous, as they may tolerate surgical aortic valve replacement (SAVR) better than expected for their age. In these cases, earlier treatment may prevent irreversible damage to the heart and reduce the risks associated with waiting until the disease progresses further.

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The aortic valve is the ‘non return’ valve positioned to prevent oxygenated blood leaving the heart from refluxing back into the heart after each heart contraction. When this valve narrows, it restricts the flow of blood leaving the heart in a condition known as ‘aortic stenosis’.

Aortic stenosis (AS) is a progressive and potentially life-threatening condition. It predominantly affects older adults and has significant implications for cardiovascular health, life expectancy, and quality of life. The incidence of AS is climbing because of increased life expectancy. Timely intervention, especially in symptomatic patients or those with progressing stenosis, is essential to optimise outcomes. This article explores the nuances of AS diagnosis, treatment decisions, and the importance of patient involvement in the care pathway.

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