The Peptide Podcast

By: The Peptide Queen
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  • Summary

  • The Peptide Podcast is on a mission to help people enjoy making decisions about their health and wellness. Staying informed with our SIMPLE, FAST, FUN approach. We keep you up-to-date on everything peptides. From disease management and prevention to performance health, anti-aging strategies, and more. We give you accurate, unbiased information so you can choose the peptides that suit YOU best. In our casual and easy-to-understand style, we’ll help you save time and energy for what matters most. About the host: Our experienced clinical pharmacist, The Peptide Queen, knows all too well that the internet is flawed, confusing, and hard to navigate. She has over 14 years of experience in retail, hospital, and specialty pharmacy, with certifications in peptide therapy, international travel medicine, immunization delivery, and pharmacogenomics. She’s passionate about helping you stay informed, save time, and feel less overwhelmed by the amount of information (or misinformation) on the internet.
    This website and its content are copyright of The Peptide Podcast - All rights reserved. Any redistribution or reproduction of part or all of the contents in any form is prohibited.
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Episodes
  • FAQs About Tirzepatide

    FAQs About Tirzepatide
    Sep 26 2024
    Curious about how tirzepatide can help with weight loss? From understanding how it works to managing potential side effects, many have questions about this medication. In this podcast, we’ll discuss the top questions to give you a clearer picture of how tirzepatide might fit into your weight loss journey. How does tirzepatide work for weight loss?Tirzepatide, marketed as Zepbound, mimics the action of GLP-1 and GIP, two hormones naturally released by your gut. These hormones are critical in regulating appetite and how much food you consume. By enhancing the feeling of fullness and reducing hunger, tirzepatide helps support weight loss. Specifically, it has the following effects: Slows stomach emptying, helping you feel full longer after meals. Decreases appetite, leading to reduced food intake. Reduces food cravings. Stimulates the pancreas to release more insulin, which lowers blood sugar levels. Reduces the liver’s new glucose production, further improving blood sugar control. These combined effects make tirzepatide a powerful tool for weight management and improving metabolic health. 1. How long does it take for tirzepatide to work? In clinical trials, people typically began to notice weight loss around 4 weeks after starting tirzepatide. This is when the medication reaches stable levels in the body. The trial lasted for 72 weeks, and the participants continued to lose weight throughout the study. However, the most significant results were observed during the first 8 to 9 months of treatment. 2. How much weight do people lose with tirzepatide? Tirzepatide is one of the most effective weight-loss treatments available. In clinical trials, people lost, on average, between 15% and 21% of their starting body weight after 72 weeks of treatment. Additionally, longer treatment with tirzepatide tends to lead to more significant weight loss. People in two different studies lost an average of 25% of their starting body weight when using tirzepatide for an extended period. 3. What’s the typical tirzepatide dosage for weight loss? The initial tirzepatide dosage is 2.5 mg once a week for the first 4 weeks. After that, the dose is increased to 5 mg weekly. Most people remain on the 5 mg dose for the long term. If necessary, the dose can be gradually increased. But the increases should be by no more than 2.5 mg at a time, and there should be at least 4 weeks in between each one. The maximum tirzepatide dose is 15mg weekly. 4. How long does tirzepatide stay in your system? Tirzepatide has a half-life of about 5 days, meaning that it takes this amount of time for your body to eliminate half of the medication. This helps determine when a medication starts wearing off and influences its dosing schedule. Since Tirzepatide’s half-life is 5 days, it only needs to be injected once weekly. On the other hand, a longer half-life means it takes more time for your body to fully eliminate a medication. In the case of tirzepatide, small amounts of the medication may remain in your system for up to 25 days after a dose. 5. How long do you need to take tirzepatide? The duration of tirzepatide treatment depends on your health and weight loss goals. It’s best to work with your healthcare provider to determine a timeline that suits your needs. Keep in mind that tirzepatide is designed for long-term use. Still, it may only be needed temporarily if you're able to adopt and sustain certain lifestyle changes after discontinuing the medication . Research shows that maintaining weight loss with tirzepatide is achievable with continued use. At the end of clinical trials, nearly 90% of participants maintained at least 80% of the weight they lost during the first 8 to 9 months. If you plan to stop taking tirzepatide, it’s important to work with your healthcare provider to develop a strategy to help maintain your weight loss. They can help create a plan to continue important lifestyle changes such as proper nutrition, regular physical activity, stress management, and quality sleep. 6. Can you change your tirzepatide injection day? Yes, you can adjust your tirzepatide injection day if needed (e.g., illness, vacation, side effects), but there are specific guidelines to follow. When switching injection days, make sure there’s at least a 3-day (72-hour) gap between two doses. For instance, if you typically inject on Saturdays, you could move it to Tuesday (or another later day in the same week). It's important to consult your healthcare provider before making this change. They can give you a safe and appropriate schedule based on your circumstances. 7. Can you switch from semaglutide to tirzepatide? Yes, you can switch from semaglutide to tirzepatide if you need additional support with weight management. Based on your current semaglutide dosage and any side effects you're experiencing, your healthcare provider may begin you on a lower dose of tirzepatide. This approach allows your body to adjust to tirzepatide ...
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    9 mins
  • SS-31

    SS-31
    Sep 19 2024
    What is SS-31? Ela-mep-ra-tide SS-31, also known as Elamipretide, is a synthetic peptide that has gained attention in the scientific and medical communities for its potential role in treating various age-related and degenerative diseases. It is a small, mitochondria-targeting peptide specifically designed to protect and improve the function of mitochondria, the energy-producing "powerhouses" of our cells. Since mitochondrial dysfunction is linked to many chronic illnesses and the aging process, SS-31 has sparked interest in its potential to restore cellular energy and combat diseases at the cellular level. In this podcast, we’ll discuss how SS-31 works and its potential benefits. How Does SS-31 Work? Mitochondria are essential for producing energy in cells through a process known as oxidative phosphorylation. During this process, mitochondria generate ATP, the primary energy source for most cellular functions. However, as we age or develop certain diseases, mitochondria can become less efficient, leading to oxidative stress and damage to cellular structures. This damage can result in various health issues, from muscle weakness to neurodegenerative diseases. SS-31 directly interacts with cardiolipin, a key phospholipid in the inner mitochondrial membrane. Cardiolipin plays an essential role in maintaining mitochondrial structure and function. When mitochondria are stressed or damaged, cardiolipin can become dysfunctional. SS-31 binds to cardiolipin and helps stabilize it, protecting mitochondria from further damage. This stabilization improves mitochondrial efficiency, reduces oxidative stress, and enhances energy production. Additionally, SS-31 helps reduce the production of reactive oxygen species (ROS), harmful molecules that can contribute to inflammation and cellular damage. By reducing oxidative stress, SS-31 may help prevent further damage to tissues and cells, slowing the progression of disease and the aging process. Potential Benefits of SS-31 Research on SS-31 is still in the early stages, but some potential benefits of this peptide have been identified, particularly in the context of mitochondrial health and age-related diseases. 1. Improved Muscle Function SS-31 has been shown to enhance muscle function, particularly in older adults or those with muscle-related diseases. By improving mitochondrial efficiency, SS-31 may help increase muscle strength and endurance, potentially benefiting conditions like sarcopenia (age-related muscle loss) and muscular dystrophies. 2. Neuroprotection Since mitochondrial dysfunction is linked to neurodegenerative diseases such as Alzheimer's and Parkinson's, SS-31’s ability to stabilize mitochondria may offer neuroprotective effects. Early research suggests that SS-31 may help protect brain cells from oxidative damage and reduce inflammation, which could slow the progression of neurodegenerative diseases. 3. Cardiovascular Health SS-31 may also have potential benefits for heart health. By protecting mitochondria in cardiac cells, SS-31 could help prevent damage to the heart and improve its function. Some studies have explored its role in treating conditions like heart failure and ischemia-reperfusion injury, where mitochondrial dysfunction plays a significant role. 4. Anti-Aging Properties Because mitochondrial damage is closely associated with aging, SS-31 may have anti-aging benefits. By improving mitochondrial function and reducing oxidative stress, SS-31 could help slow the aging process at the cellular level, promoting healthier aging and potentially extending lifespan. 5. Treatment of Metabolic Disorders There is growing interest in SS-31’s potential to treat metabolic disorders such as diabetes. Mitochondrial dysfunction is linked to insulin resistance, and improving mitochondrial function with SS-31 could enhance glucose metabolism and insulin sensitivity. 6. Increased energy levels SS-31 peptide boosts energy by targeting and protecting mitochondria, the "powerhouses" of your cells. Mitochondria generate ATP, the main energy source for cellular functions. As we age or experience stress, mitochondrial efficiency declines, leading to fatigue and reduced cellular energy. SS-31 works by stabilizing the mitochondria, preventing oxidative damage, and improving ATP production. This results in increased cellular efficiency, allowing you to feel more energized. It's like upgrading an old car engine—it runs smoother, more efficiently, and with less strain, giving you more stamina throughout the day. What to listen to next: To learn more about how other peptides can help with neurodegenerative diseases, listen to our podcast discussing the potential use of GLP-1 agonists in Alzheimer’s disease and how they work or DIHEXA and cognitive health. To learn more about how other peptides can help heart health, listen to our podcast about GLP-1 agonists in the context of post-MI management. Thanks again for listening to The Peptide Podcast. We love ...
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    5 mins
  • Differences Between Semaglutide and Tirzepatide

    Differences Between Semaglutide and Tirzepatide
    Sep 12 2024
    Two of the most promising treatments for obesity in recent years are semaglutide, a GLP-1 agonist, and tirzepatide, a dual GLP-1/GIP agonist. These peptides have garnered attention for their impressive efficacy in weight loss and metabolic improvement, but they differ in their mechanisms, dosing, side effects, and outcomes. In this podcast, we'll explore how these peptides compare. Semaglutide and tirzepatide work in similar but slightly different ways for weight loss Semaglutide works by mimicking glucagon-like peptide-1 (GLP-1), a hormone that is naturally released by the gut in response to food. GLP-1 helps regulate appetite by increasing the feeling of fullness (satiety), slowing gastric emptying, and reducing the body's insulin resistance. It also stimulates insulin secretion, which helps control blood sugar levels, making it useful not only for weight loss but also for managing type 2 diabetes. Tirzepatide activates both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors. GIP is another hormone involved in insulin secretion, but it also plays a role in fat metabolism. By engaging both receptors, tirzepatide has a dual/additive impact: it not only boosts insulin sensitivity and appetite suppression (similar to semaglutide) but also enhances the body's ability to process fat and use it for energy — providing an added benefit for weight loss and metabolic health. Tirzepatide may result in greater weight loss compared with semaglutide Semaglutide has been shown to reduce body weight by 10-15% in most clinical trials, with some patients achieving even greater weight loss (up to 17% of total body weight). Additionally, it has proven effective in reducing blood glucose levels and improving insulin sensitivity, making it a great option for patients with type 2 diabetes and obesity. Tirzepatide has shown superior weight loss efficacy, with reductions of up to 20-25% of body weight in clinical trials. Its dual action on GLP-1 and GIP receptors may explain this enhanced efficacy. It also offers significant improvements in metabolic markers, including better glucose control and insulin sensitivity, which can especially benefit patients with obesity-related metabolic disorders (e.g., type 2 diabetes and polycystic ovary syndrome) Semaglutide and tirzepatide have different doses Semaglutide is typically administered as a once-weekly injection. The dosing for weight loss starts at 0.25 mg per week and gradually increases in 4-week intervals to a maintenance dose of 2.4 mg per week. The gradual titration helps minimize side effects such as nausea. Sometimes, the semaglutide dose may be increased sooner than the 4-week interval based on the person’s response to the peptide. Tirzepatide is also administered as a once-weekly injection. The dosing for weight loss starts at 2.5 mg per week and gradually increases to a maintenance dose of 5 mg to 7.5 mg per week, with some people requiring higher doses (10 mg, 12.5 mg, or 15 mg). The dose is generally increased based on patient tolerance, similar to semaglutide but shouldn’t be increased sooner than 4 weeks. Semaglutide and tirzepatide have similar side effects Common side effects of semaglutide include: Nausea Vomiting Diarrhea Constipation Headache Tiredness These stomach-related side effects are usually temporary and go away on their own as the body adjusts to the medication. However, some people may experience more severe symptoms, necessitating a lower dose. Tirzepatide shares many of the same side effects as semaglutide, including: Nausea Vomiting Diarrhea Constipation Burping Flatulence Indigestion Keep in mind: Tirzepatide's side effects can sometimes be more pronounced, particularly during the dose-escalation phase. Some patients may also experience signs of low blood sugar, especially if used in combination with insulin. Semaglutide may be a better option if you have heart disease In March 2024, semaglutide received additional FDA approval for reducing cardiovascular risk in adults with heart disease who are overweight or obese. Clinical studies show that semaglutide reduced the risk of major adverse cardiovascular events—such as heart attack, stroke, or cardiovascular death—by 20%. Tirzepatide is currently being studied for similar cardiovascular benefits. Semaglutide and tirzepatide may have benefits for other health conditions Semaglutide has demonstrated positive outcomes in certain people with heart failure, and a recent study suggests potential kidney-related benefits for those with heart disease. It is also being studied as a treatment for metabolic dysfunction-associated steatohepatitis (MASH), also known as non-alcoholic steatohepatitis, a condition caused by excess fat accumulation in the liver. Tirzepatide has shown promise for individuals with moderate-to-severe obstructive sleep apnea and may receive approval for this use by late 2024. Additionally, it is under investigation for potential benefits...
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    8 mins
Alternative & Complementary Medicine Exercise & Fitness Hygiene & Healthy Living
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