The Peter Attia Drive

By: Peter Attia MD
  • Summary

  • The Peter Attia Drive will feature guests and experts that will offer advice and insight to help you optimize performance, health, longevity, critical thinking, and life. It’s hosted by Stanford M.D., TED speaker, and longevity expert Dr. Peter Attia, founder of Attia Medical, PC, a medical practice with offices in San Diego and New York City.
    Copyright © Peter Attia, MD
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Episodes
  • #332 - AMA #67: Microplastics, PFAS, and phthalates: understanding health risks and a framework for minimizing exposure and mitigating risk
    Jan 20 2025
    View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter’s Weekly Newsletter In this “Ask Me Anything” (AMA) episode, Peter tackles a topic that's been dominating headlines and sparking widespread concern: microplastics and plastic-associated chemicals, including BPA, PFAS, and phthalates. Peter explores the science behind these substances including how and why they've become so prevalent, the extent of our exposure, and the potential risks to our health. Most importantly, he provides a practical framework for understanding microplastics and plastic-associated chemicals and minimizing exposure while distinguishing genuine risks from exaggerated concerns. If you’re not a subscriber and are listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #67 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here. We discuss: The complexity of the topic of microplastics and associated chemicals [1:30];Definitions: microplastics, BPA, PM2.5, phthalates, and more [6:30];The reasons behind the increase in microplastics in our environment and the surge in interest in them [12:00];The various ways that humans are exposed to microplastics and nanoplastics [14:00];Volume of plastic consumed by humans, and how the body eliminates or absorbs microplastics [16:00];How microplastics accumulate in the body, the variability in tissue accumulation, and the challenges in studying their long-term health effects [21:30];Limitations of blood tests for microplastics, and the importance of reliable biomarkers for guiding behavior and interventions [26:30];The speculative health risks of microplastics, the limitations of current research, and the need for more robust studies [29:15];The challenges of measuring microplastics in human tissues, the need for better methodologies, and the importance of critically evaluating study relevance and claims [39:45];If it’s unclear whether microplastics actually cause harm, should we still be concerned about exposure? [42:15];Strategies to minimize microplastic exposure [45:00];The financial cost and effort involved in various microplastic exposure mitigation strategies [51:00];The role of airborne microplastics in total exposure and accumulation [1:03:00];Chemicals associated with plastics, their role as endocrine disruptors, and the challenges in linking exposure to specific health outcomes [1:04:00];BPAs: role in plastic production, and its potential developmental risks [1:05:45];BPA's potential health risks: pregnancy, fertility, obesity, and diabetes, and the socioeconomic confounders in the data [1:08:30];Regulatory limits on BPA exposure, and practical considerations for reducing exposure [1:12:45];The prevalence of BPA in modern products and how to identify it [1:17:15]; PFAS: chemical structure and purpose in products [1:18:30]; Why PFAS are considered endocrine disruptors [1:19:45];The main sources of PFAS exposure, and practical steps to reduce exposure [1:21:30];The potential health risks of PFAS exposure [1:24:00];Phthalates: role in making plastics flexible and presence in personal care products [1:24:45];Why phthalates are considered endocrine disruptors [1:25:15];The main sources of phthalate exposure, and how manufacturing practices are evolving to reduce exposure [1:26:45];Practical strategies to reduce exposure to phthalates in food, air, water, and personal care products [1:28:30];Navigating microplastics and associated chemicals: a framework for personalized risk reduction [1:29:30]; andMore. Connect With Peter on Twitter, Instagram, Facebook and YouTube
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    25 mins
  • #331 ‒ Optimizing endurance performance: metrics, nutrition, lactate, and more insights from elite performers | Olav Aleksander Bu (Pt. 2)
    Jan 13 2025

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    Olav Aleksander Bu is an internationally renowned sports scientist acclaimed for his coaching prowess with elite athletes spanning a diverse range of sports disciplines. In this episode, Olav returns to dive deeper into his groundbreaking work as an endurance coach, exercise scientist, engineer, and physiologist. The discussion explores his data-driven approach to coaching, unpacking key performance metrics like functional threshold power, VO2 max, and lactate threshold, while emphasizing the importance of consistent testing protocols. Olav shares insights on how training methodologies differ across sports, the impact of nutrition on endurance performance, and the evolving strategies for carbohydrate metabolism in fueling athletes for races. Olav concludes with a discussion on the use of artificial intelligence for optimizing training insights and performance.

    We discuss:

    • Olav’s unique, engineering-driven approach to endurance coaching [2:45];
    • Definitions and applications of key performance metrics: FTP, power, anaerobic threshold, and lactate threshold [4:45];
    • Lactate threshold: factors affecting lactate threshold, testing protocols, and how elite athletes' efficiency affects their performance and lactate profiles [14:15]
    • VO2 max: definition, testing, factors affecting its accuracy, and methods for optimizing oxygen utilization in elite athletes [22:15];
    • Testing VO2 max: common mistakes and key factors to consider—preparation, warm-up, timing, and more [34:00];
    • VO2 max testing continued: measuring instruments, testing protocols, and advanced insights gained from elite athletes [41:45];
    • The influence of supplements like beetroot concentrate and adaptogens on VO2 max and performance [49:45];
    • How respiratory quotient (RQ) reflects metabolic shifts during exercise, the challenges in measuring and interpreting RQ in elite athletes, and the physiological adaptations needed for prolonged endurance events [53:30];
    • Triathlon training: the challenge of maintaining elite performance across triathlon distances, metabolic efficiency, and swimming challenges [1:03:15];
    • How reducing drag in swimming could revolutionize performance and the role of biofeedback tools in optimizing efficiency across various endurance sports [1:07:00];
    • How endurance athletes prioritize effort regulation using RPE, heart rate, and power output, and the role of lactate in cardiac and athletic efficiency [1:20:00];
    • Lactate’s role as a fuel, buffering methods to combat lactic acidosis, and the variability in athlete response to bicarbonate supplementation [1:25:45];
    • The physiological mechanisms behind differences in performance between two elite athletes: lactate transport, cardiovascular efficiency, and compensatory systems [1:33:00];
    • Comparing interventions like acetaminophen to enhance performance in high-heat conditions versus natural adaptations to heat [1:37:15];
    • Advancements in nutrition science, changes in cyclist body composition, and the impact of fueling strategies on athletic performance and growth [1:39:30];
    • Optimizing endurance performance with utilization of carbohydrates, and the potential role of ketones [1:48:00];
    • Insights gained from elite performers in the 2020 and 2024 Olympics [1:58:30];
    • The use of artificial intelligence to optimizing training insights and performance [2:06:30]; and
    • More.

    Connect With Peter on Twitter, Instagram, Facebook and YouTube

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    2 hrs and 16 mins
  • #330 – Autism, ADHD, and Anxiety: Understanding the rise in autism and a multidisciplinary approach to diagnosis and treatment of each condition in children | Trenna Sutcliffe, M.D.
    Jan 6 2025

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    Trenna Sutcliffe is a developmental behavioral pediatrician and the founder and medical director of the Sutcliffe Clinic in the San Francisco Bay Area, where she partners with families to provide care for children facing behavioral challenges, developmental differences, and school struggles. In this episode, Trenna shares her journey into developmental and behavioral pediatrics, including her pioneering work at Stanford and her expertise in autism, ADHD, and anxiety—the "three As." She explores the diagnostic processes, the overlap and comorbidities of these conditions, and the importance of personalized treatment plans that address both medical and environmental factors. Trenna offers valuable insights into the changing prevalence of autism, the impact of evolving diagnostic criteria, and the range of therapies and medications available to support children and their families. She also discusses the challenges in accessing care and the critical need for a holistic approach that bridges healthcare and education.

    We discuss:

    • Trenna’s passion for developmental-behavioral pediatrics (DBP), and the process of diagnosing anxiety, ADHD, and autism [3:15];
    • Understanding anxiety and ADHD: assessing impairment and self-esteem and identifying anxiety and emotional well-being in young patients [9:45];
    • The evolving diagnosis of autism: understanding the spectrum and individual needs [16:30];
    • The dramatic rise in autism spectrum disorder (ASD): genetics, environment, expanded diagnostic criteria, and more [25:45];
    • Exploring epigenetics and the potential multigenerational impact of environment exposures on susceptibility to certain disorders [37:15];
    • The evolution of autism classifications, and the particular challenges for children with level 1 (mild) autism due to a lack of support [41:15];
    • The broadening of the autism spectrum: benefits and risks of expanded diagnostic criteria and the need for future frameworks to focus on better outcomes [48:00];
    • The overlap between ASD, ADHD, and anxiety [57:15];
    • Understanding oppositional defiant disorder, and the importance of understanding the “why” behind a behavior when creating treatment plans [1:00:45];
    • Defining developmental-behavioral pediatrics (DBP), and Trenna’s professional journey [1:07:00];
    • Updated methods of ABA (applied behavioral analysis) therapy: evolution, controversies, challenges of scaling autism care, and the need for tailored interventions [1:13:45];
    • Advice for parents trying to find and evaluate care for children with autism, ADHD, or anxiety [1:22:45];
    • Tailored treatments for ADHD: balancing stimulant medications with behavioral training [1:28:30];
    • The interplay between medication, behavioral therapy, and neuroplasticity in managing ADHD, and the potential to grow out of the need for medication [1:39:45];
    • Using medication to treat anxiety and other symptoms in kids with autism without ADHD [1:44:45];
    • FAQs about medicating children with ADHD: benefits, side effects, dosage, and more [1:46:30];
    • The “superpowers” associated with level 1 autism [1:48:45];
    • The next steps to increase support for children with ASD, anxiety, and ADHD [1:50:45]; and
    • More.

    Connect With Peter on Twitter, Instagram, Facebook and YouTube

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    1 hr and 57 mins

What listeners say about The Peter Attia Drive

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so grateful..

Remarkable podcast with so much valuable information on how to live our best life.

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Love!

As usual learned a lot.
Can't wait for the next episode.
Three more words.

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Helpful

Reminded me of the importance of exercise. Thank you for this experience. Very helpful and insightful.

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Very informative

I get so much out of Peter Attia. Thanks so much for doing all this.

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Deep info

Top of the line pro information. Complex but understandabele, and very complete, superb guests, great interviews

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Responsibly sourced information.

Excellently sourced and presented information that allows the listener to discern what to take away and what to leave. Great guests and peter is a great interviewer.

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excellent knowledge!

as a female trainer of over 20 years I thoroughly appreciate listening to thoughtful dedicated and committed women in the industry. excellent interview I learned a lot thank you so much.

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A Smart Guy Talks to Other Smart People

If you are a person concerned about health and longevity and are ready to dive into more technical, sciencey info this dude is for you. Recommend you have some level of understanding of biology to reap most benefits of listening.

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WOW!

Great information on concussions & their treatment. amazing how far the knowledge base has increased in 20 years.

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