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Join Dr. Sandra Cammarata and Dr. Giovanni Campanile as they speak with Dr. Dominic D’Agostino, Associate Professor at the University of South Florida and research scientist at the Institute for Human and Machine Cognition (IHMC). Renowned for his work on metabolic therapies, Dr. D’Agostino has led pioneering research into how nutritional ketosis, fasting, and oxygen physiology can enhance human resilience—particularly in extreme environments like deep-sea diving and spaceflight.

With a unique focus on translational research, Dr. D’Agostino has studied the therapeutic potential of ketogenic diets and exogenous ketones in treating neurological diseases, cancer, and metabolic disorders. His work spans the lab to the real world, including collaborations with NASA, the Department of Defense, and elite military groups. This episode explores the science behind metabolic flexibility, resilience under stress, and how a shift in cellular fuel can unlock profound therapeutic benefits.

Find more of Dr. D'Agostino here:

https://drdominicdagostino.com/profile/

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functionalheart.com
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Join Dr. Sandra Cammarata and Dr. Giovanni Campanile as they speak with Dr. Jens Juul Holst, the renowned Danish physiologist and co-discoverer of GLP-1 (glucagon-like peptide-1), one of the most significant hormones in metabolic disease research. A professor of medical physiology at the University of Copenhagen and former scientific director at the Novo Nordisk Foundation Center for Basic Metabolic Research, Dr. Holst has spent decades unraveling the gut’s intricate role in glucose metabolism and appetite regulation.

In this interview, Dr. Holst reflects on his journey from surgical training to groundbreaking endocrinology, detailing how GLP-1 emerged as a therapeutic cornerstone in the treatment of type 2 diabetes and obesity. He explores its far-reaching effects—ranging from cardiovascular and neuroprotective benefits to appetite and weight regulation—and shares insight into the future of metabolic therapies, including combination treatments and oral delivery strategies.

With honors including the Banting Medal, the Canada Gairdner Award, and the Breakthrough Prize in Life Sciences, Dr. Holst’s work has helped transform the landscape of modern medicine. This episode offers a compelling look at the science behind GLP-1 and the global impact of one of the most important endocrine discoveries of our time.

Find more of us here:

Websites:
https://siciliansecret.com/
coraeon.com
functionalheart.com
Our Book: https://www.amazon.com/Sicilian-Secret-Diet-4-color-trade/dp/189969496X/
Our Supplements: https://www.amazon.com/dp/B0BWZLCM6H
Youtube: https://www.youtube.com/@siciliansecretdiet
Instagram: https://www.instagram.com/siciliansecretdiet/
Facebook: https://www.facebook.com/Sicilian-Secret-Diet-106204798725447
Tiktok: https://www.tiktok.com/@siciliansecretdiet
Apple Podcasts: https://podcasts.apple.com/gb/podcast/the-sicilian-secret-diet/id1566575032

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Join Dr. Sandra Cammarata and Dr. Giovanni Campanile as they interview Brady Holmer, an exercise physiologist, researcher, and science communicator whose work bridges the gap between exercise science and public health. With a background in integrative physiology and cardiovascular research, Brady brings a rigorous yet accessible perspective to how physical activity shapes human health and longevity.

Brady completed his graduate work at the University of Florida, where he studied the effects of exercise on cardiovascular function and heart rate variability. His research has focused on VO₂ max, endurance physiology, and how training adaptations influence markers of healthspan and disease risk. He has also contributed to the translation of complex scientific findings into meaningful strategies for improving performance and long-term well-being.

Beyond the lab, Brady is a well-known writer and podcaster, hosting the Science & Chill podcast and contributing to platforms like Examine.com. Through his clear and evidence-based communication, Brady empowers both lay audiences and professionals to better understand the profound impact of movement and exercise on health throughout the lifespan.

Find more of Bradly Holmer here:

https://linktr.ee/bradyholmer?fbclid=PAZXh0bgNhZW0CMTEAAaesx2qvu1SI1aRmIv2AgB5l2r7L8b6MtOfQVUSv1u9sNBYGBuMLc7LpGiAzbw_aem_uuWfdr-vie_EigU-qPBTHQ

Find more of us here:

Websites:
https://siciliansecret.com/
coraeon.com
functionalheart.com
Our Book: https://www.amazon.com/Sicilian-Secret-Diet-4-color-trade/dp/189969496X/
Our Supplements: https://www.amazon.com/dp/B0BWZLCM6H
Youtube: https://www.youtube.com/@siciliansecretdiet
Instagram: https://www.instagram.com/siciliansecretdiet/
Facebook: https://www.facebook.com/Sicilian-Secret-Diet-106204798725447
Tiktok: https://www.tiktok.com/@siciliansecretdiet
Apple Podcasts: https://podcasts.apple.com/gb/podcast/the-sicilian-secret-diet/id1566575032