This Week in Virology

By: Vincent Racaniello
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  • Summary

  • TWiV is a podcast about viruses - the kind that make you sick.
    Vincent Racaniello 2022
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Biological Sciences Natural History
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Episodes
  • TWiV 1189: Viruses making waves

    TWiV 1189: Viruses making waves
    Feb 2 2025

    TWiV notes the HHS communication pause, and describes research showing that rotavirus viroporin activity is necessary for intracellular calcium signals that contribute to viral pathogenesis, and control of human orthrflavivirus vaccine challenge by T cells in the absence of neutralizing antibodies.

    Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker

    Subscribe (free): Apple Podcasts, RSS, email

    Become a patron of TWiV!

    Links for this episode
    • Support science education at MicrobeTV
    • ASV 2025
    • Rotavirus viroporin activity, calcium waves, and pathogenesis (Sci Adv)
    • T cells control human orthoflavivirus challenge (Nat Micro)
    • Letters read on TWiV 1189
    • Timestamps by Jolene Ramsey. Thanks!
    Weekly Picks

    Brianne – The Perfect Cacio e Pepe Recipe, According to Science (primary article here)
    Kathy – Dragonflies Loop-the-Loop
    Alan – My Beloved Monster, by Caleb Carr
    Vincent – Why Did the FDA Ban Red Dye #3

    Listener Picks

    Anne – Japan’s 65-Foot Towering Snow Walls

    Intro music is by Ronald Jenkees

    Send your virology questions and comments to twiv@microbe.tv

    Content in this podcast should not be construed as medical advice.
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    1 hr and 33 mins
  • TWiV 1188: Clinical update with Dr. Daniel Griffin

    TWiV 1188: Clinical update with Dr. Daniel Griffin
    Feb 1 2025
    In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss changes in access to public health information, the Marburg and Ebola outbreaks in Africa, the largest tuberculosis outbreak in the US ever, the politicization of polio vaccine campaigns in Pakistan, effect of high pathogenic influenza in animals and on the economy before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, trials and devices to relieve some neurological complications of long COVID and the ramifications of long COVID in children, healthcare workers and adults. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode No morbidity and mortality in the US this week? (NPR)More support for Marburg outbreak in Tanzania (Reliefweb)Tanzania confirming second Marburg case (CIDRAP) Norovirus mRNA vaccine …..hmmmm? (moderna) What is noronvirus? (modernatx)Largest tuberculosis outbreak ever in the US (Reuters) Ebola outbreak in DRC during US:WHO strain (STAT News) Uganda Ebola outbreak…..1 dead (Reuters)Polio outside endemic zone due to militants? (Washington Post)Mpox vaccination initiation in central Africa (CIDRAP)Preparing rapid response to emerging infectious disease in Africa (PANTHER Health)Mpox therapeutic study MOSA enrollment begins (Africa CDC) Halting of US foreign aid for health programs…..not in the US best interests? (NY Times) No PEPFAR (NY Times)PEPFAR (US Department of State)PEPFAR…..still not America first? Really? (CIDRAP)Resurgence of infections globally may affect US…..what is global health? (NY Times) Milk testing for H5N1….but I thought raw milk was the only healthy milk? (USDA)How do you like your $10.99 dozen of eggs? (NY Times) Farm outbreak of H5N1 (AP News)US- high pathogenicity avian influenza viruses (World Organization for Animal Health)H5N9 high pathogenic flu in duck farm California (CIDRAP)More egg issues (CIDRAP)Waste water scan for 11 pathogens (WastewaterSCan)US respiratory virus activity (CDC Respiratory Illnesses)Weekly surveillance report: cliff notes (CDC FluView)RSV: Waste water scan for 11 pathogens (WastewaterSCan)RSV-Network (CDC Respiratory Syncytial virus Infection)US respiratory virus activity (CDC Respiratory Illnesses)Respiratory syncytial virus vaccine effectiveness among US veterans, September, 2023 to March, 2024 (LANCET Infectious Diseases)Waste water scan for 11 pathogens (WastewaterSCan)COVID-19 deaths (CDC)COVID-19 national and regional trends (CDC)COVID-19 variant tracker (CDC)SARS-CoV-2 genomes galore (Nextstrain)Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)Fusion center near you….if in NY (Prime Fusions) CDC Quarantine guidelines (CDC)NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society)Drug interaction checker (University of Liverpool)Molnupiravir safety and efficacy (JMV)Convalescent plasma recommendation for immunocompromised (ID Society)What to do when sick with a respiratory virus (CDC)When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)Managing healthcare staffing shortages (CDC)Steroids, dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org)Daniel Griffin’s evidence based medical practices for long COVID (OFID)Long COVID hotline (Columbia : Columbia University Irving Medical Center)The answers: Long COVIDLong COVID Recovery Program with Zara Dureno, BA, MOTThe current and future burden of long COVID in the United States (JID)Transcutaneous vagus nerve stimulation improves Long COVID symptoms in a female cohort (Frontiers in Neurology)Transcutaneous vagus nerve stimulation trials: https://www.mountsinai.org/clinical-trials/tvns-in-long-covid-19 https://www.centerwatch.com/clinical-trials/listings/NCT06585254/tvns-in-long-covid-19 Devices: https://pulsetto.tech/products/meet-pulsetto?pulsetto_offer_id=57&transaction_id=1024e5a0258b6647e262ba8fec5d62 https://www.dolphinmps.com/product/dolphin-neurostim-professional-single-kit-vagal-stim-kit/Distinct pro-inflammatory/pro-angiogenetic signatures distinguish children with Long COVID from controls (Pediatric Research)Persistent symptoms and clinical findings in adults with post-acute sequelae of COVID-19/post-COVID-19 syndrome in the second year after acute infection(PLoS Medicine)SARS-COV-2 re-infection and incidence of post-acute sequelae of COVID-19 (PASC) among essential workers in New York (LANCET: Regional Health Americas)Impact of COVID-19 Pandemic on the incidence and...
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    48 mins
  • TWiV 1187: The tau of herpesvirus

    TWiV 1187: The tau of herpesvirus
    Jan 26 2025

    TWiV explains a new blood test for head and neck cancer, Japanese regulators approve tecovirimat for mpox, an entry receptor for enterovirus D68, and anti-herpetic tau preserves neurons via a DNA sensing pathway in Alzheimer’s disease.

    Hosts: Vincent Racaniello, Kathy Spindler, Brianne Barker, and Angela Mingarelli

    Subscribe (free): Apple Podcasts, RSS, email

    Become a patron of TWiV!

    Links for this episode
    • Support science education at MicrobeTV
    • ASV 2025
    • Entry receptor for EV-D68 (Cell Host Microbe)
    • Anti-herpetic tau preserves neurons in Alzheimers (Cell Rep)
    • Letters read on TWiV 1187
    • Timestamps by Jolene Ramsey. Thanks!
    Weekly Picks

    Angela – Good genes are nice, but joy is better
    Brianne – Beaker Hair Clip
    Kathy – Pareidolia explained by street artist David Zinn TEDx talk Also visit zinnart.com
    Alan – Screwworm is coming back in the Americas
    Vincent – Dr. Jay Bhattacharya Was Nice to Someone During a Debate. That Doesn’t Erase the Consequences of His Misinformation

    Listener Picks

    Sarah – The Extremophile Campaign: In Your Home (ECIYH) citizen science

    Intro music is by Ronald Jenkees

    Send your virology questions and comments to twiv@microbe.tv

    Content in this podcast should not be construed as medical advice.
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    1 hr and 57 mins

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Profile Image for Kari Helgerud

Love it!

Science first and yet entertaining.
Wonderful gang full of knowledge and joy for related topics.

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Profile Image for M. Rossiter

Excellent Source

I found TWiV through the recommendation of another podcast. Like many I am a post covid follower and I have really appreciated TWiV as a source of current and accurate information. The clinical updates with Dr. Griffin are so useful . Dr Gritting uses language that I, a custodian i.e. not a science professional am able to understand. I find the clinical updates really ease my anxieties because finally I understand what is going on around me. Sometimes the other episodes I struggle to totally follow along but I always finish having learned something I didn't know before listening. Turns out virology and immunology is quite fascinating!

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Profile Image for norman rogers

Fun team

You need a background in Bio to enjoy this podcast, but if you are on the in you should have a great time.

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Very good science podcast!

The content is really good and always interesting with many great guests. Good job guys!

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Profile Image for portia shao

A good thing from the pandemic years

I discovered TWiV during 2020 due to the desire for more accurate and unbiased information about the viruses and then stayed for the good and interesting science. I never liked biology before but have found the discussions to be reasons to get interested in not only virology but biology, microbiology, even medicine. Although I don’t understand all the science, to hear the unfamiliar multiple times made them less intimidating and I feel like I am sitting in the same room as the host and guest scientists week after week when different topics are being discussed. The weekly clinical updates are also keeping me well informed about the viruses that we should be aware of in a timely way. Love this podcast and many sister podcasts from microbe.tv

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