J.O.

Three red-headed women - One, Two, and Three - do not know one another though they live only a few miles apart. Each is being hunted by a psychopath intent on committing three perfect murders, works of such artistic brilliance that they will be written about and studied in universities for decades to come. The women know they have been marked for death - they just don't know when it is to happen, or how, or by whom. Or why.

A retired university professor has just been diagnosed with a rare degenerative disease. Returning home from the doctor’s office, he witnesses a pretty young girl being kidnapped. Believing the police are dragging their feet, he vows to find her on his own. He knows that if he doesn’t act, she may never be found alive. Jennifer Riggins, the kidnapped girl, is being held prisoner by a depraved couple who have started an exclusive website called What Comes Next. Viewers can watch her terrifying ordeal in real time.

Newly minted chief resident at Boston Memorial Hospital Noah Rothauser is swamped in his new position, from managing the surgical schedules to dealing with the fallouts from patient deaths. Known for its medical advances, the famed teaching hospital has fitted several ORs as "hybrid operating rooms of the future" - an improvement that seems positive until an anesthesia error during a routine procedure results in the death of an otherwise healthy man.

Pia Grazdani is an exceptional yet aloof medical student working closely with Columbia University Medical Center's premier scientist on cutting-edge research that could revolutionize health care by creating replacement organs for critically ill patients. Thorough her work with the brilliant molecular geneticist Dr. Tobias Rothman, Pia knows she will be given the chance to fulfill her ambition to participate in medical discoveries that can help millions while bringing her a measure of personal peace.

Colleagues-turned-spouses Dr. Laurie Montgomery and Dr. Jack Stapleton already have their plates full with demanding forensic pathology work and family pressures. The last thing they need is the sudden death of a colleague. Yet when Laurie’s apparently vital and healthy longtime friend Dr. Sue Passero dies mysteriously in the hospital parking garage, an autopsy is required, and it falls uncomfortably under Laurie’s purview as the chief medical examiner. So when Laurie asks Jack to take special care with the case, he can hardly refuse.