
A Fatal Inheritance
How a Family Misfortune Revealed a Deadly Medical Mystery
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Narrated by:
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Roger Wayne
About this listen
Long-listed, BookPage Best Books of the Year, 2024
National Book Critics Circle Award nominee, 2024
Long-listed, Amazon.com Best Books of the Year, 2024
Long-listed, NPR Best Book of the Year, 2024
"Listeners will find A Fatal Inheritance to be an effective overview of research on cancer and hereditary predisposition, one that achieves serious investigation while remaining intensely human.”—BookPage
Weaving his own moving family story with a sweeping history of cancer research, Lawrence Ingrassia delivers an intimate, gripping tale that sits at the intersection of memoir and medical thriller
Ingrassia lost his mother, two sisters, brother, and nephew to cancer—different cancers developing at different points throughout their lives. And while highly unusual, his family is not the only one to wonder whether their heartbreak is the result of unbelievable bad luck, or if there might be another explanation.
Through meticulous research and riveting storytelling, Ingrassia takes us from the 1960s—when Dr. Frederick Pei Li and Dr. Joseph Fraumeni Jr. first met, not yet knowing that they would help make a groundbreaking discovery that would affect cancer patients for decades to come—to present day, as Ingrassia and countless others continue to unpack and build upon Li and Fraumeni’s initial discoveries, and to understand what this means for their families.
In the face of seemingly unbearable loss, Ingrassia holds onto hope. He urges us to “fight like Charlie,” his nephew who battled cancer his entire life starting with a rare tumor in his cheek at the age of two—and to look toward the future, as gene sequencing, screening protocols, CRISPR gene editing, and other developing technologies may continue to extend lifespans and perhaps, one day, even offer cures.
A Macmillan Audio production from Henry Holt & Company.
©2024 Lawrence Ingrassia (P)2024 Macmillan AudioListeners also enjoyed...
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Critic reviews
“A Fatal Inheritance by Lawrence Ingrassia is a compelling personal chronicle of tragedy and triumph. It captures both the ineffable pain of families riddled with cancers and the remarkable research over the past half century by scientists determined to help them.”—Siddhartha Mukherjee, author of The Emperor of All Maladies: A Biography of Cancer
"When two young doctors came across a family riddled with cancer for generations, they wondered why and began a decades long search for the answer. In A Fatal Inheritance, a riveting narrative of their quest, Lawrence Ingrassia intertwines a deeply personal and tearful story of unbearable family loss with an inspiring story of scientific discovery that revolutionized the understanding and treatment of cancer."—Walter Isaacson, author of Elon Musk, The Code Breaker and Steve Jobs
"When Lawrence Ingrassia lost his mother, sisters, brother and nephew to cancer, was it appallingly bad luck, or was there a common cause? This is the story of a family tragedy, a medical mystery, and the painstaking work of insightful scientists. By turns heartbreaking and hopeful, A Fatal Inheritance is a story of mortal loss and human resilience."—Geraldine Brooks, author of Horse and March
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Performance
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At 5:12 am on April 18, 1906, a 7.9 magnitude earthquake struck San Francisco, catching most of the city asleep. For approximately forty-eight seconds, shock waves buckled streets, shattered water mains, collapsed buildings, crushed hundreds of residents to death, and trapped many alive. Matthew Davenport draws on letters, diaries, unpublished memoirs, and previously unearthed archival records, as well as interviews with engineers and geologists, to combine history and science to tell the dramatic true story of one of the greatest disasters in American history.
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History told from those who survived
- By BamaState on 12-26-23
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I Am Bunny
- How a ""Talking"" Dog Taught Me Everything I Need to Know About Being Human
- By: Alexis Devine
- Narrated by: Alexis Devine
- Length: 6 hrs and 35 mins
- Unabridged
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When Bunny, a fluffy, black-and-white sheepadoodle, was eight weeks old, her guardian Alexis presented her with an odd gift: a button programed to say “outside” when pressed. Within a few weeks, Bunny was using it all the time and Alexis, encouraged by Bunny’s progress, continued to introduce more buttons and more words . . . Three years later, Bunny can now communicate using over one hundred buttons, stringing together important, relatable, philosophical phrases such as “Love you Mom,” “Dad went poop,” and “Ugh why?”
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Excellent, well worth the time!
- By Amazon Customer on 05-29-25
By: Alexis Devine
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A Woman in Berlin
- Eight Weeks in the Conquered City: A Diary
- By: Anonymous, Philip Boehm - translator
- Narrated by: Isabel Keating
- Length: 10 hrs and 26 mins
- Unabridged
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For eight weeks in 1945, as Berlin fell to the Russian army, a young woman kept a daily record of life in her apartment building and among its residents. The anonymous author depicts her fellow Berliners in all their humanity, as well as their cravenness, corrupted first by hunger and then by the Russians. A Woman in Berlin tells of the complex World War II relationship between civilians and an occupying army and the shameful indignities to which women in a conquered city are always subject—the mass rape suffered by all, regardless of age or infirmity.
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Interesting
- By northwoods woman on 06-25-20
By: Anonymous, and others
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The Treeline
- The Last Forest and the Future of Life on Earth
- By: Ben Rawlence
- Narrated by: Jamie Parker
- Length: 11 hrs and 59 mins
- Unabridged
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For the last 50 years, the trees of the boreal forest have been moving north. The Treeline takes us along this critical frontier of our warming planet from Norway to Siberia, Alaska to Greenland, to meet the scientists, residents, and trees confronting huge geological changes.
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A surprising find
- By BearheartRaven on 02-23-22
By: Ben Rawlence
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Around the World in Eighty Games
- From Tarot to Tic-Tac-Toe, Catan to Chutes and Ladders, a Mathematician Unlocks the Secrets of the World's Greatest Games
- By: Marcus du Sautoy
- Narrated by: Mark Elstob
- Length: 12 hrs and 36 mins
- Unabridged
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Spanning millennia, oceans and continents, countries and cultures, Around the World in Eighty Games gleefully explores how mathematics and games have always been deeply intertwined. Renowned mathematician Marcus du Sautoy investigates how games provided the first opportunities for deep mathematical insight into the world, how understanding math can help us play games better, and how both math and games are integral to human psychology and culture.
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Overall, a very entertaining read.
- By Matt on 11-13-23
By: Marcus du Sautoy
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Do I Know You?
- A Faceblind Reporter's Journey into the Science of Sight, Memory, and Imagination
- By: Sadie Dingfelder
- Narrated by: Sadie Dingfelder
- Length: 7 hrs and 26 mins
- Unabridged
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Science writer Sadie Dingfelder has always known that she’s a little quirky. But while she’s made some strange mistakes over the years, it’s not until she accosts a stranger in a grocery store (whom she thinks is her husband) that she realizes something is amiss. With a mixture of curiosity and dread, Dingfelder starts contacting neuroscientists and lands herself in scores of studies. In the course of her nerdy midlife crisis, she discovers that she is emphatically not neurotypical.
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The author’s curiosity keeps you interested from beginning to end
- By Ross D. Martin MD on 06-29-24
By: Sadie Dingfelder
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Nazi Wives
- The Women at the Top of Hitler's Germany
- By: James Wyllie
- Narrated by: Dalya Raphael
- Length: 9 hrs and 30 mins
- Unabridged
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Goering, Goebbels, Himmler, Heydrich, Hess, Bormann - names synonymous with power and influence in the Third Reich. Perhaps less familiar are Carin, Emmy, Magda, Margarete, Lina, Ilse, and Gerda. These are the women behind the infamous men - complex individuals with distinctive personalities who were captivated by Hitler and whose everyday lives were governed by Nazi ideology. Throughout the rise and fall of Nazism these women loved and lost, raised families, and quarreled with their husbands and each other, all the while jostling for position with the Fuhrer himself.
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Scary
- By Three River on 05-15-21
By: James Wyllie
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The King's Assassin
- The Secret Plot to Murder King James I
- By: Benjamin Woolley
- Narrated by: David Timson
- Length: 12 hrs and 17 mins
- Unabridged
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An absorbing account of the conspiracy to kill King James I by his handsome lover, the duke of Buckingham, a historical crime that has remained hidden for 400 years....
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Wonderful read!
- By LaDonna on 10-26-24
By: Benjamin Woolley
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Descent into Darkness
- Pearl Harbor, 1941, A Navy Diver's Memoir
- By: Edward C. Raymer
- Narrated by: Peter Johnson
- Length: 7 hrs and 24 mins
- Unabridged
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On December 7, 1941, as the great battleships Arizona, Oklahoma, and Utah lie paralyzed and burning in the aftermath of the Japanese attack on Pearl Harbor. A crack team of U.S. Navy salvage divers headed by Edward C. Raymer are hurriedly flown to Oahu from the mainland. Their two-part orders are direct and straightforward: (1) rescue as many trapped sailors and Marines as possible, and (2) resurrect what remains of America's once mighty pacific fleet. Descent Into Darkness tells their story.
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A Massive Disappointment
- By Matthew on 10-14-15
By: Edward C. Raymer
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Lucid Dying
- The New Science Revolutionizing How We Understand Life and Death
- By: Sam Parnia MD PhD
- Narrated by: Brian Nishii
- Length: 11 hrs and 39 mins
- Unabridged
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Today, for the first time in history, the scientific exploration of death and what happens when we die is real, active and ongoing. Contrary to popular perceptions, this subject is no longer the remit of philosophy, religion, or personal opinion. Truly remarkable scientific discoveries that will fundamentally affect everyone’s lives now and in the future are taking place, yet very few people are aware of them. Most people—including scientists and doctors—maintain strong beliefs about death and its experience. Those beliefs are rooted in traditional, and often cultural, notions of death.
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Excited to See Scientific Rigor Applied to This Vital Topic
- By Mav on 08-27-24
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The Burning Shore
- How Hitler's U-Boats Brought World War II to America
- By: Ed Offley
- Narrated by: Robertson Dean
- Length: 7 hrs and 18 mins
- Unabridged
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On June 15, 1942, as thousands of vacationers lounged in the sun on Virginia Beach, a massive fireball erupted from a convoy of oil tankers steaming into Chesapeake Bay. By the next day, three ships lay at the bottom of the channel, victims of Lieutenant-Commander Horst Degen and his crew on the German submarine U-701. In The Burning Shore, acclaimed military reporter Ed Offley presents a thrilling account of Degen's rampage along the American coast and of US Lieutenant Harry J. Kane's quest to bring him down.
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Ugh, Perhaps a Second Listen is Required?
- By Matthew on 09-05-15
By: Ed Offley
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Riding Home
- The Power of Horses to Heal
- By: Tim Hayes
- Narrated by: David Stifel
- Length: 8 hrs and 23 mins
- Unabridged
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Riding Home:The Power of Horses to Heal, is the first and only audiobook to scientifically and experientially explain why horses have the extraordinary ability to emotionally transform the lives of thousands of men, women and children, whether they are horse lovers, or suffering from deep psychological wounds. It is an audiobook for anyone who wants to experience the joy, wonder, self-awareness and peace of mind that comes from creating a horse/human relationship, and it puts forth and clarifies the principles of today's Natural Horsemanship....
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So disappointed
- By Crystal Matthews on 03-24-22
By: Tim Hayes
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Through the Valley
- My Captivity in Vietnam
- By: William Reeder Jr.
- Narrated by: Corey M. Snow
- Length: 8 hrs and 11 mins
- Unabridged
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In 1971 William Reeder was a senior captain on his second tour in Vietnam. He had flown armed, fixed-wing OV-1 Mohawks on secret missions deep into enemy territory in Laos, Cambodia, and North Vietnam, on his first tour. He returned as a helicopter pilot eager to experience a whole new perspective as a Cobra gunship pilot. Believing that Nixon's Vietnamization would soon end the war, Reeder was anxious to see combat action. To him, it appeared that the Americans had prevailed, beaten the Viet Cong, and were passing everything over to the South Vietnamese Army so Americans could leave.
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Best narration.
- By Speed77 on 01-05-25
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Why I Stayed
- The Choices I Made in My Darkest Hour
- By: Gayle Haggard, Angela Hunt - contributor
- Narrated by: Gayle Haggard
- Length: 9 hrs and 55 mins
- Unabridged
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On November 2, 2006, Gayle Haggard's life changed forever when her husband, Ted Haggard, founder of the 14,000-member New Life Church in Colorado Springs and president of the National Association of Evangelicals, was publicly exposed in a scandal. In the days and months ahead, everything in Gayle's life was at stake—her beliefs, her marriage, and her relationship with the church community she had been a part of for more than 20 years.
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Loved it!
- By Christi L. Ashton-Poloha on 07-15-18
By: Gayle Haggard, and others
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Turning to Stone
- Discovering the Subtle Wisdom of Rocks
- By: Marcia Bjornerud
- Narrated by: Rebecca Stern
- Length: 9 hrs and 41 mins
- Unabridged
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Earth has been reinventing itself for more than four billion years, keeping a record of its experiments in the form of rocks. Yet most of us live our lives on the planet with no idea of its extraordinary history, unable to interpret the language of the rocks that surround us. Geologist Marcia Bjornerud believes that our lives can be enriched by understanding our heritage on this old and creative planet. Contrary to their reputation, rocks have eventful lives—and they intersect with our own in surprising ways.
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Very unusual book by a profound writer
- By F Shaw on 09-17-24
By: Marcia Bjornerud
Powerful story told incredibly well
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Fascinating medical nonfiction
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The history of the discovery of this particularly brutal heritable cancer syndrome is absolutely fascinating and Lawrence Engrassia skillfully weaves this together with stories from the initial families studied to ascertain the cause of the syndrome with stories of his own family. The details of these families repeated suffering as family member after family member is torn from them will forever be indelibly seared into my memory.
Absolutely beautifully written, fascinating, poignant, tragic and unforgettable.
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An important book
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An Elucidating Memoir
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Stunning story and great reporting
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Very Interesting and Informative
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Touching story with powerful lessons in hope.
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Full of emotion
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The research
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