The future looks bright for John and Ruby. John's business is growing, and they're talking about starting a family. But when Ruby receives a life-changing diagnosis, and insurance won't cover the treatment, John steals a customer's identity and files a false claim. The plan works perfectly - until the customer in question contacts John with a startling proposition. If John and Ruby play a little game he's devised, he won't report their fraud. The rules are simple: commit real crimes.

Charlie Giles is at the top of his game. An electronics superstar, he’s sold his startup company to a giant Boston firm, where he’s now a senior director. With his dog, Monte, at his side, Charlie is treated like a VIP everywhere he goes. Then one day, everything in Charlie’s neatly ordered world starts to go terrifyingly wrong. His prestigious job and his inventions are wrenched away from him. His family is targeted, and his former employers are dying gruesomely, picked off one by one. Every sign, every shred of evidence, points to Charlie as a cold-blooded killer.

Nine years after he left Shilo, New Hampshire, former Navy SEAL Tom Hawkins has moved back. It’s not an auspicious homecoming. Tom has returned to raise his teenage daughter, Jill, following the murder of his ex-wife, Kelly. Despite Tom’s efforts to stay close to Jill by coaching her high school soccer team, Kelly’s bitterness fractured their relationship. But together, they are on the mend, and life in Shilo is starting to shape up into something approaching normal. Normal doesn’t last long. Shilo’s police sergeant makes it clear that Tom is his chief suspect in Kelly’s death.

When President Geoffrey Hilliard’s son Cam, a 16-year-old chess champion, experiences extreme fatigue, moodiness, and an uncharacteristic violent outburst, doctors are quick to dismiss his troubles as teen angst. But Secret Service agent Karen Ray summons her physician ex-husband for a second opinion. Dr. Lee Blackwood’s concerns are dismissed by the president's team - until Cam gets sicker. Lee must make a diagnosis from a puzzling array of symptoms he's never seen before. His only clue is a patient named Susie Banks, a young musical prodigy who seems to be suffering from the same baffling condition as Cam.

Dr. Carrie Bryant's four years as a neurosurgical resident at White Memorial Hospital have earned her the respect and admiration from peers and staff alike. When given the chance of performing her first unsupervised brain surgery, Carrie jumps at the opportunity. What should have been a routine, hours-long operation turns horribly wrong and jeopardizes her patient's life. Emotionally and physically drained, Carrie is rushed back to the OR to assist in a second surgery.

After the killing of a prominent mob lawyer, NYPD homicide detectives Jacob Jackson and Caitlin Grimes start receive chilling, written “rules” for how to commit the perfect murder. "Rule number one for the perfect murder: Evidence is your enemy. Leave none behind." Jackson (Reid Scott) and Grimes (Cobie Smulders) race to find the killer, setting them on a collision course with the city’s crime underbelly, and a perpetrator who seems happy to toy with them. “Rule number two. No crimes of passion. The perfect murder is always business, never pleasure.”

Kidnappers grabbed Jenna in broad daylight, right in front of her children and their horrified classmates. Her family was issued an insane ransom demand: $25 million in cash and jewels, payable by the end of the school day, otherwise they’ll never see her again. As Jenna’s mother scrambles to gather the money, detectives Mo Butler and George Ortega follow the trail of the kidnappers, which will lead them through a sordid landscape of jealous lovers, broken dreamers, and twisted schemers. But every second counts, and there’s one thing Jenna Wade doesn’t have: very much time.

When Heather McKinley dreamed of becoming a doctor, she imagined curing sick kids and sporting pink stethoscopes. She never anticipated the sleepless nights, grueling exams, and endless labs. And she certainly never knew that her medical school earned the nickname Dead Med thanks to the tragic history of students overdosing on illegal drugs. But Heather would never consider doing anything like that. That is, until her longtime boyfriend dumps her, she finds herself failing anatomy, and her world starts to crumble.

Lowen Ashleigh is a struggling writer on the brink of financial ruin when she accepts the job offer of a lifetime. Jeremy Crawford, husband of best-selling author Verity Crawford, has hired Lowen to complete the remaining books in a successful series his injured wife is unable to finish. Lowen arrives at the Crawford home, ready to sort through years of Verity's notes and outlines, hoping to find enough material to get her started. What Lowen doesn't expect to uncover in the chaotic office is an unfinished autobiography Verity never intended for anyone to read.

Cassie thinks she has met the perfect man. Joel is sweet, handsome, romantic, and best of all, he’s crazy about Cassie. She thinks she’s found the guy she’ll spend the rest of her life with. Have children with. Grow old with. Yes, she knows about his perfect ex-girlfriend, Francesca. The beautiful, brilliant chef, beloved by all his friends. But she thinks Francesca is out of the picture. She thinks Francesca is gone for good. Think again, Cassie.

Jenny sits in the same seat on the same train every week, seeing familiar faces come and go. Until a chance encounter shatters her world. Sixteen years ago, Jenny survived a traumatic ordeal that left her best friend, Susie, missing and presumed dead. The world has its theories about what happened to Susie Patterson, and one of those theories points the finger at Jenny. Now she lives a quiet life, volunteering at a crisis helpline while trying to deal with her own anxiety and the true crime fans obsessed with finding her missing friend.

Jazz Bashara is a criminal. Well, sort of. Life on Artemis, the first and only city on the moon, is tough if you're not a rich tourist or an eccentric billionaire. So smuggling in the occasional harmless bit of contraband barely counts, right? Not when you've got debts to pay and your job as a porter barely covers the rent. Everything changes when Jazz sees the chance to commit the perfect crime, with a reward too lucrative to turn down.

They were madly in love. The perfect couple. That was the story everyone in South River believed...until Gin Talcott and Adam Archer are found shot in their bed. Adam is dead at the scene. Gin is fighting for her life. Detectives Greta Jessup and Finn Pate are assigned to the case. Greta has a long history with Gin’s first husband, Eddie, and is determined to protect his 18-year-old twins. Piper discovered the bodies. Daniel is missing—and so is Adam’s gun.

Sloan will go through hell and back for those she loves. And she does so, every single day. Caught up with the alluring Asa Jackson, a notorious drug trafficker, Sloan has finally found a lifeline to cling to, even if it’s meant compromising her morals. She was in dire straits trying to pay for her brother’s care until she met Asa. But as Sloan became emotionally and economically reliant on him, he in turn developed a disturbing obsession with her—one that becomes increasingly dangerous every day.

Tess Strebel can’t recognize her own face. She can’t recognize her home. Her bedroom is unfamiliar. And she can’t remember the handsome stranger lying next to her in bed. A stranger who claims he’s her husband. Tess reads a letter in her own handwriting, composed during a rare lucid day, explaining her life as it now exists: she was in a terrible car accident one year ago. Every morning, she wakes up unable to remember most of the last decade. Including her own wedding.