David Burroughs was once a devoted father to his three-year-old son Matthew, living a dream life just a short drive away from the working-class suburb where he and his wife, Cheryl, first fell in love—until one fateful night when David woke suddenly to discover Matthew had been murdered while David was asleep just down the hall.

When Jake Dent's dreams of baseball glory fell apart in a drunk-driving incident, his marriage did, too. He's become an avid doomsday prepper, raising his diabetic son, Andy, to be ready for any sudden catastrophe.

The future looks bright for John and Ruby. John's business is growing, and they're talking about starting a family. But when Ruby receives a life-changing diagnosis, and insurance won't cover the treatment, John steals a customer's identity and files a false claim. The plan works perfectly - until the customer in question contacts John with a startling proposition. If John and Ruby play a little game he's devised, he won't report their fraud. The rules are simple: commit real crimes.

When President Geoffrey Hilliard’s son Cam, a 16-year-old chess champion, experiences extreme fatigue, moodiness, and an uncharacteristic violent outburst, doctors are quick to dismiss his troubles as teen angst. But Secret Service agent Karen Ray summons her physician ex-husband for a second opinion. Dr. Lee Blackwood’s concerns are dismissed by the president's team - until Cam gets sicker. Lee must make a diagnosis from a puzzling array of symptoms he's never seen before. His only clue is a patient named Susie Banks, a young musical prodigy who seems to be suffering from the same baffling condition as Cam.

Every day without fail, Travis Devine puts on a cheap suit, grabs his faux-leather briefcase, and boards the 6:20 commuter train to Manhattan, where he works as an entry-level analyst at the city’s most prestigious investment firm. In the mornings, he gazes out the train window at the lavish homes of the uberwealthy, dreaming about joining their ranks. In the evenings, he listens to the fiscal news on his phone, already preparing for the next grueling day in the cutthroat realm of finance. Then one morning Devine’s tedious routine is shattered by an anonymous email: She is dead.