When the world is still counting the cost of the Second World War and the Iron Curtain has closed, eleven-year-old Roland Baines's life is turned upside down. 2,000 miles from his mother's protective love, stranded at an unusual boarding school, his vulnerability attracts piano teacher Miss Miriam Cornell, leaving scars as well as a memory of love that will never fade.

One day, Lori Gottlieb is a therapist who helps patients in her Los Angeles practice. The next, a crisis causes her world to come crashing down. Enter Wendell, the quirky but seasoned therapist in whose of­fice she suddenly lands. With his balding head, cardigan, and khakis, he seems to have come straight from Therapist Central Casting. Yet he will turn out to be anything but.

Sam and Sadie—two college friends, often in love, but never lovers—become creative partners in a dazzling and intricately imagined world of video game design, where success brings them fame, joy, tragedy, duplicity, and, ultimately, a kind of immortality. It is a love story, but not one you have heard before.

At 32 Russell Green has it all: a stunning wife, a lovable six-year-old daughter, a successful career as an advertising executive, and an expansive home in Charlotte. He is living the dream, and his marriage to the bewitching Vivian is the center of that. But underneath the shiny surface of this perfect existence, fault lines are beginning to appear, and no one is more surprised than Russ when he finds every aspect of the life he took for granted turned upside down.

Nina Browning is living the good life after marrying into Nashville's elite. More recently, her husband made a fortune selling his tech business, and their adored son has been accepted to Princeton. Yet sometimes the middle-class small-town girl in Nina wonders if she's strayed from the person she once was. Tom Volpe is a single dad working multiple jobs while struggling to raise his headstrong daughter, Lyla. His road has been lonely, long, and hard, but he finally starts to relax after Lyla earns a scholarship to Windsor Academy, Nashville's most prestigious private school.

Young Pip Tyler doesn't know who she is. She knows that her real name is Purity, that she's saddled with $130,000 in student debt, that she's squatting with anarchists in Oakland, and that her relationship with her mother - her only family - is hazardous. But she doesn't have a clue who her father is, why her mother chose to live as a recluse with an invented name, or how she'll ever have a normal life.

Grace Reinhart Sachs is living the only life she ever wanted for herself. Devoted to her husband, a pediatric oncologist at a major cancer hospital, their young son Henry, and the patients she sees in her therapy practice, her days are full of familiar things: She lives in the very New York apartment in which she was raised, and sends Henry to the school she herself once attended. Dismayed by the ways in which women delude themselves, Grace is also the author of a book You Should Have Known, in which she cautions women to really hear what men are trying to tell them.

Tessa Russo is the mother of two young children and the wife of a renowned pediatric surgeon. Despite her own mother's warnings, Tessa has recently given up her career to focus on her family and the pursuit of domestic happiness. From the outside, she seems destined to live a charmed life. Valerie Anderson is an attorney and single mother to six-year-old Charlie - a boy who has never known his father.

First comes love. Then comes marriage. Then comes...a baby carriage? Isn’t that what all women want? Not so for Claudia Parr. And just as she gives up on finding a man who feels the same way, she meets warm, wonderful Ben. Things seem too good to be true when they fall in love and agree to buck tradition with a satisfying, child-free marriage. Then the unexpected occurs: one of them has a change of heart.

Wife. Mother. Breadwinner. Penelope Ruiz-Kar is doing it all - and barely keeping it together. Meanwhile, her best friend, Jenny Sweet, appears to be sailing through life. As close as the two women are, Jenny’s passionate marriage, pristine house, and ultra-polite child stand in stark contrast to Penelope’s underemployed husband, Sanjay, their unruly brood, and the daily grind she calls a career.

Heloise considers it a blessing to be a person who seldom attracts attention. In her suburb, she's just a mom, the young widow with the forgettable job, who somehow never misses a soccer game. In the state capital, she's the redheaded lobbyist with a good cause and a mediocre track record. But in discreet hotel rooms throughout the area, she's the woman of your dreams - if you can afford the hourly fee. For more than a decade, Heloise believed she was safe, managing to keep up this rigidly compartmentalized life. But her secret life is under siege. One county over, another so-called suburban madam has been found dead in her car, an apparent suicide.

Louis Charles ("Lucy") Lynch has spent all his 60 years in upstate Thomaston, New York, married to the same woman, Sarah, for 40 of them, their son now a grown man. Like his late, beloved father, Lucy is an optimist, though he's had plenty of reasons not to be: chief among them his mother, still indomitably alive.

Nathan Glass has come to Brooklyn to die. Divorced, estranged from his only daughter, the retired life insurance salesman seeks only solitude and anonymity. Then Nathan finds his long-lost nephew, Tom Wood, working in a local bookstore, a far cry from the brilliant academic career he'd begun when Nathan saw him last. Tom's boss is the charismatic Harry Brightman, whom fate has also brought to the "ancient kingdom of Brooklyn, New York".

Two very different women with this in common: Each harbors her own secret, her own reason why she can't just let this go. Neither can yield, not before they've dredged up all that's hidden, even if it has the power to shatter all they've built.

At fifty-three, Maggie Harris has a good marriage and two mostly happy children. Perpetually anxious, she’s also accumulated a list of semi-reasonable fears: falling air conditioners, the IRS, identity theft, skydiving, and airbag recalls. But never once did Maggie worry that her husband of nearly thirty years would leave her.