Sam and Sadie—two college friends, often in love, but never lovers—become creative partners in a dazzling and intricately imagined world of video game design, where success brings them fame, joy, tragedy, duplicity, and, ultimately, a kind of immortality. It is a love story, but not one you have heard before.

In medical school, Paul Farmer found his life’s calling: to cure infectious diseases and to bring the lifesaving tools of modern medicine to those who need them most. Tracy Kidder’s magnificent account shows how one person can make a difference in solving global health problems through a clear-eyed understanding of the interaction of politics, wealth, social systems, and disease. Profound, Mountains Beyond Mountains takes us from Harvard to Haiti, Peru, Cuba, and Russia as Farmer changes people’s minds through his dedication to the philosophy that “the only real nation is humanity.”

When his sister tricks him into taking her guru on a trip to their childhood home, Otto Ringling, a confirmed skeptic, is not amused. Six days on the road with an enigmatic holy man who answers every question with a riddle is not what he'd planned. But in an effort to westernize his passenger---and amuse himself---he decides to show the monk some "American fun" along the way.

The summer that Nixon resigns, six teenagers at a summer camp for the arts become inseparable. Decades later the bond remains powerful, but so much else has changed. In The Interestings, Wolitzer follows these characters from the height of youth through middle age, as their talents, fortunes, and degrees of satisfaction diverge. The kind of creativity that is rewarded at age 15 is not always enough to propel someone through life at age 30; not everyone can sustain, in adulthood, what seemed so special in adolescence.

Young Pip Tyler doesn't know who she is. She knows that her real name is Purity, that she's saddled with $130,000 in student debt, that she's squatting with anarchists in Oakland, and that her relationship with her mother - her only family - is hazardous. But she doesn't have a clue who her father is, why her mother chose to live as a recluse with an invented name, or how she'll ever have a normal life.

John Hodgman - New York Times best-selling author, semifamous personality, deranged millionaire, increasingly elderly husband, father, and human of Earth - has written a memoir about his cursed travels through two wildernesses: from the woods of his home in Massachusetts, birthplace of rage, to his exile on the coast of Maine, so-called Vacationland, home to the most painful beaches on Earth.

Amy Bloom began to notice changes in her husband, Brian: He retired early from a new job he loved; he withdrew from close friendships; he talked mostly about the past. Suddenly, it seemed there was a glass wall between them, and their long walks and talks stopped. Their world was altered forever when an MRI confirmed what they could no longer ignore: Brian had Alzheimer’s disease.

The inimitably witty David Rakoff, New York Times best-selling author of Don’t Get Too Comfortable, defends the commonsensical notion that you should always assume the worst, because you’ll never be disappointed. In this deeply funny (and, no kidding, wise and poignant) audiobook, Rakoff examines the realities of our sunny, gosh­ everyone-can-be-a-star contemporary culture and finds that, pretty much as a universal rule, the best is not yet to come, adversity will triumph, justice will not be served, and your dreams won’t come true.

The unforgettable voyager of this dark picaresque is I. B. "Berl" Pickett, M.D., whose die was probably cast the moment his mother thought to name him after Irving Berlin. Other insults piled on apace thereafter: the spasms of Pentecostal Sunday worship; the social debilitation of following his parents' itinerant rug-shampooing business; the erotic initiation at the hands of his aunt. It's hard to imagine what would have become of him had he not gone to medical school.

Run, Hide, Repeat is a memoir of a childhood steeped in unexplained fear and menace. Gripping and suspenseful, it moves from Dakin's uneasy acceptance of her family's dire situation to bewildered anger. As compelling and twisted as a thriller, Run Hide Repeat is an unforgettable portrait of a family under threat and the resilience of family bonds.

Julie fully expected to be breathing at the end of the trip - but driving into Death Valley felt like giving up, surrendering. She'd spent years battling a mysterious illness so extreme that she often couldn't turn over in her bed. The top specialists in the world were powerless to help, and research on her disease, chronic fatigue syndrome, was at a near standstill. Having exhausted the plausible ideas, Julie turned to an implausible one. Going against both her instincts and her training, she followed the advice of strangers she'd met on the Internet.

101 True Stories about how Positive Thinking can change your life! Everyone needs a little attitude adjustment once in a while, and these amazing true life stories reveal how real people used positive thinking to improve their lives and overcome challenges. You’ll read stories about how you can make every day a special day, incorporate gratitude and joy into your daily life, count your blessings and change your outlook, use a few well-chosen words to reorient your life, manage cancer and other health challenges through a positive attitude, simplify and have a more meaningful life and more!

What makes you happy? Others share how they found their passion, purpose, and joy in life in these 101 personal and exciting stories that are sure to inspire and encourage listeners to find their own happiness. Chicken Soup for the Soul: Find Your Happiness will encourage listeners to pursue their dreams, find their passion and seek joy in their life with its 101 personal and inspiring stories. This book continues Chicken Soup for the Soul’s focus on inspiration and hope, reminding us that we all can find our own happiness.

A hilarious and heartbreaking memoir-in-remedies by a self-described "professional soul-searcher" that details a journey of self-discovery through more than 160 tonics, seminars, regimens, and transformative therapies. With a voice that is at once intimate and hilarious, Megan captures the openness and honesty necessary for people to take a new path in life. Listeners will open the audiobook with curiosity about all the different healing therapies that Megan tries, but leave with a new understanding of themselves.

Abe Ravelstein is a brilliant professor at a prominent Midwestern university and a man who glories in training the movers and shakers of the political world. He has lived grandly and ferociously - and much beyond his means. His close friend Chick has suggested that he put forth a book of his convictions about the ideas that sustain humankind, or kill it, and much to Ravelstein’s own surprise, he does and becomes a millionaire.

The unforgettable voyager of this dark picaresque is I. B. "Berl" Pickett, M.D., whose die was probably cast the moment his mother thought to name him after Irving Berlin. Other insults piled on apace thereafter: the spasms of Pentecostal Sunday worship; the social debilitation of following his parents' itinerant rug-shampooing business; the erotic initiation at the hands of his aunt. It's hard to imagine what would have become of him had he not gone to medical school.

101 True Stories about how Positive Thinking can change your life! Everyone needs a little attitude adjustment once in a while, and these amazing true life stories reveal how real people used positive thinking to improve their lives and overcome challenges. You’ll read stories about how you can make every day a special day, incorporate gratitude and joy into your daily life, count your blessings and change your outlook, use a few well-chosen words to reorient your life, manage cancer and other health challenges through a positive attitude, simplify and have a more meaningful life and more!

What makes you happy? Others share how they found their passion, purpose, and joy in life in these 101 personal and exciting stories that are sure to inspire and encourage listeners to find their own happiness. Chicken Soup for the Soul: Find Your Happiness will encourage listeners to pursue their dreams, find their passion and seek joy in their life with its 101 personal and inspiring stories. This book continues Chicken Soup for the Soul’s focus on inspiration and hope, reminding us that we all can find our own happiness.

A hilarious and heartbreaking memoir-in-remedies by a self-described "professional soul-searcher" that details a journey of self-discovery through more than 160 tonics, seminars, regimens, and transformative therapies. With a voice that is at once intimate and hilarious, Megan captures the openness and honesty necessary for people to take a new path in life. Listeners will open the audiobook with curiosity about all the different healing therapies that Megan tries, but leave with a new understanding of themselves.

One September morning in 2008, an investment banker approaching forty, his career in collapse and his marriage unraveling, receives a surprise visitor at his West London townhouse. In the disheveled figure of a South Asian male carrying a backpack the banker recognizes a long-lost friend, a mathematics prodigy who disappeared years earlier under mysterious circumstances. The friend has resurfaced to make a confession of unsettling power.

In a narrative that spans geography and time, from the Atlantic Ocean in the 17th century to a correctional institute in Texas in the near future, and told from the perspectives of five very different characters, Speak considers what it means to be human and what it means to be less than fully alive.

Alan Gregory is a clinical psychologist with a thriving practice in Boulder, Colorado. His life begins to unravel when one of his female patients is found in an apparent suicide and the local paper begins printing accusations from an unnamed source of sexual impropriety between the woman and Dr. Gregory. He launches a psychological and personal quest for the truth that rapidly intensifies when more of his patients die untimely deaths, and Gregory suspects not only that the deaths are related but that another one of his patients may be somehow involved. Lacking facts but roused by suspicion and troubled by seemingly random acts of terror around him, Gregory starts to fear for the safety of the people he loves. The question of the inviolability of confidential disclosures made to Gregory by his patients - privileged information - becomes crucial as the psychologist pursues an unsettling romance with Lauren Crowder, a lovely deputy district attorney investigating one of the deaths. Bound to silence, Gregory follows the psychological tracks of someone he fears may be a cunning and disturbed killer, while turning to his enigmatic but supportive partner, Diane Estevez, for counsel, and to his tart-tongued female urologist neighbor for support. The sinister, surprising drama unfolds against Boulder's Rocky Mountain backdrop, in the arresting natural beauty of Aspen, and in the midst of a baroque Halloween costume party in downtown Boulder. Finally, in a lonely mountain lodge enshrouded in menace, the story comes to its breathtaking climax.

It's a report tempered by hard times. In "Matricide", Daum unflinchingly describes a parent's death and the uncomfortable emotions it provokes; and in "Diary of a Coma" she relates her own journey to the twilight of the mind. But Daum also operates in a comic register. With perfect precision, she reveals the absurdities of the marriage-industrial complex, of the New Age dating market, and of the peculiar habits of the young and digital.

When journalist Steve Lopez sees Nathaniel Ayers playing his heart out on a two-string violin on Los Angeles' skid row, he finds it impossible to walk away. More than 30 years ago, Ayers was a promising classical bass student at Juilliard - ambitious, charming, and also one of the few African-Americans there - until he gradually lost his ability to function, overcome by schizophrenia.

Over time, the two men form a bond and Lopez imagines that he might be able to change Ayers' life. The Soloist is a beautifully told story of devotion in the face of seemingly unbeatable challenges.

The complex, deeply binding relationship between mothers and daughters is brought vividly to life in Katie Hafner's remarkable memoir, an exploration of the year she and her mother, Helen, spent working through, and triumphing over, a lifetime of unresolved emotions. Dreaming of a "year in Provence" with her mother, Katie urges Helen to move to San Francisco to live with her and Zoe, Katie's teenage daughter. Katie and Zoe had become a mother-daughter team, strong enough, Katie thought, to absorb the arrival of a 77-year-old woman set in her ways....

It begins with a glimpse or a passing thought. It ends in obsession. One day a renowned author discovers that his wife, a war correspondent, has disappeared leaving no trace. Though time brings more success and new love, he remains mystified - and increasingly fascinated - by her absence. Was she kidnapped, blackmailed, or simply bored with their marriage? The unrest she causes is as strong as the attraction she exerts.

Heloise considers it a blessing to be a person who seldom attracts attention. In her suburb, she's just a mom, the young widow with the forgettable job, who somehow never misses a soccer game. In the state capital, she's the redheaded lobbyist with a good cause and a mediocre track record. But in discreet hotel rooms throughout the area, she's the woman of your dreams - if you can afford the hourly fee. For more than a decade, Heloise believed she was safe, managing to keep up this rigidly compartmentalized life. But her secret life is under siege. One county over, another so-called suburban madam has been found dead in her car, an apparent suicide.

In this lyrical, unsentimental, and compelling memoir, the son of a Black African father and a White American mother searches for a workable meaning to his life as a Black American. It begins in New York, where Barack Obama learns that his father - a figure he knows more as a myth than as a man - has been killed in a car accident. This sudden death inspires an emotional odyssey - first to a small town in Kansas, from which he retraces the migration of his mother’s family to Hawaii, and then to Kenya, where he meets the African side of his family.

Blending literature and memoir, Ann Patchett, author of State of Wonder and Bel Canto examines her deepest commitments: to writing, family, friends, dogs, books, and her husband in This Is the Story of a Happy Marriage. Together, these essays, previously published in The Atlantic, Harper, Vogue, and The Washington Post, form a resonant portrait of a life lived with loyalty and with love.

In Let's Take the Long Way Home, Pulitzer Prize-winning author Gail Caldwell offers a powerful and moving memoir about her coming-of-age in mid-life and her extraordinary friendship with Caroline Knapp, the author of Drinking: A Love Story. Though they are more different than alike, these two fiercely private, independent women quickly relax into a friendship more profound than either of them expected. They grow increasingly inseparable until, in 2003, Caroline is diagnosed with Stage IV lung cancer.