On the surface, these seven women are as different as can be - but each has had her share of bad luck, from cheating husbands to sexist colleagues to a legal system that often doesn't do its job. Now, drawn together by tragedy, they're forging a bond that will help them right the wrongs committed against them and discover an inner strength they didn't know they had. The Sisterhood is learning that when bad things happen, you can roll over and play dead...or you can get up fighting...

Sam Acquillo is at the end of the line: he's a middle-aged corporate dropout living in a ramshackle cottage in Southampton's North Sea. But then the old lady next door ends up floating dead in her bathtub, and it seems that Sam is the only one who wonders why.

Samantha Sweet breaks into houses for a living - all perfectly legal as a caretaker for the USDA. But her real dream is to open her own pastry shop, 'Sweet's Sweets.' Life is a little crazy for Sam right now. At one of her break-in properties, a dying woman insists that she take a small wooden box. Sam doesn't realize that the old woman was known locally as a 'bruja,' a witch, until she begins to feel some strange effects from the box.

How does a woman protect herself from an enemy she can’t see? Law school graduate Whitney Garrison is a survivor. She admirably deals with her mother’s death, mounting student debt, dwindling job opportunities, an abusive boyfriend, and a rare neurological condition that prevents her from recognizing human faces. But witnessing a murder might be the crisis she can’t overcome.

Ian isn't crazy. Life would be a lot simpler if he was. He's eighteen, on the run, and scared - the shape-shifting delusions he's had since childhood have turned out to be real. He's the result of a dynamic mimicry project intended to help undercover agents "go grey" and blend in unnoticed. Now the biotech company wants its property back, and the only people he can trust are two private military contractors sent to find him...

In the southwestern desert, a mysterious cult prays for the return of the Visitors. Only one creature can derail that grand and glorious event: An evil entity, known as the Duad, can keep the Visitors from arriving and prevent the transfiguration to come. Daley, who lives nearby, has a far more serious problem: an alien consciousness that has taken up residence in her head.

Nestled on the Oregon coast is a small town of rocky beaches and rugged charm. Locals love the land’s unspoiled beauty. Developers see it as a potential gold mine. When newcomer Hank Cooper learns he’s been left an old friend’s entire beachfront property, he finds himself with a community’s destiny in his hands. Cooper has never been a man to settle in one place, and Thunder Point was supposed to be just another quick stop. But Cooper finds himself getting involved with the town. And with Sarah Dupre, a woman as complicated as she is beautiful.

Vida is only 19, but she knows a lot about dying. Her weak heart has kept her on the edge of death her whole life. It hasn't been much of a life. Thanks to her overprotective mother, Vida's only friend is Esther, an elderly Holocaust survivor who lives upstairs. Vida's heart is finally about to give out unless she can get a donor heart in time. Richard is 36 and blissfully married until he gets the call that his beloved wife has died in a car accident. His world falls to pieces.

Celebrity Charles James can't shake the nightmare that wakes him each night. He sees himself walking down a long, broken highway, the sides of which are lit in flames. Where is he going? Why is he walking? What is the wailing he hears around him? By day he wonders why he's so haunted and unhappy when he has all he ever wanted - fame, fans, and fortune and the lavish lifestyle it affords him. Coming from a childhood of poverty and pain, this is what he's dreamed of. But now, at the pinnacle of his career, he's started to wonder if he's wanted the wrong things.

After a rough divorce, Abby McCree only wants to stitch up her life and move on. But other loose ends appear after her elderly Aunt Sybil passes away, leaving Abby to tend to a rundown estate, complete with a slobbery Mastiff of questionable pedigree and a sexy tenant who growls more than the dog. As Abby gets drawn into a tight-knit quilting guild, she makes a twisted discovery - Aunt Sybil's only known rival is buried in her backyard! Despite what local detectives say, Abby refuses to accept that her beloved aunt had anything to do with the murder.